期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
Legionella pneumophila-mediated host posttranslational modifications 被引量:1
1
作者 Yi Yang Ligang Mei +4 位作者 Jing Chen Xiaorong Chen zhuolin wang Lu Liu Aimin Yang 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2023年第5期7-20,共14页
Legionella pneumophila is a Gram-negative bacterium ubiquitously present in freshwater environments and causes a serious type of pneumonia called Legionnaires’disease.During infections,L.pneumophila releases over 300... Legionella pneumophila is a Gram-negative bacterium ubiquitously present in freshwater environments and causes a serious type of pneumonia called Legionnaires’disease.During infections,L.pneumophila releases over 300 effector proteins into host cells through an Icm/Dot type IV secretion system to manipulate the host defense system for survival within the host.Notably,certain effector proteins mediate posttranslational modifications(PTMs),serving as useful approaches exploited by L.pneumophila to modify host proteins.Some effectors catalyze the addition of host protein PTMs,while others mediate the removal of PTMs from host proteins.In this review,we summarize L.pneumophila effector-mediated PTMs of host proteins,including phosphorylation,ubiquitination,glycosylation,AMPylation,phosphocholination,methylation,and ADP-ribosylation,as well as dephosphorylation,deubiquitination,deAMPylation,deADP-ribosylation,dephosphocholination,and delipidation.We describe their molecular mechanisms and biological functions in the regulation of bacterial growth and Legionella-containing vacuole biosynthesis and in the disruption of host immune and defense machinery. 展开更多
关键词 Legionella pneumophila bacterial effector posttranslational modification host-pathogen interaction Legionellacontaining vacuole PATHOGENESIS host defense system
原文传递
Determination of mechanical parameters for elements in meso-mechanical models of concrete 被引量:1
2
作者 Xianglin GU Junyu JIA +2 位作者 zhuolin wang Li HONG Feng LIN 《Frontiers of Structural and Civil Engineering》 SCIE EI CSCD 2013年第4期391-401,共11页
The responses of cement mortar specimens of different dimensions under compression and tension were calculated based on the discrete element method with the modified-rigid-body-spring concrete model,in which the mecha... The responses of cement mortar specimens of different dimensions under compression and tension were calculated based on the discrete element method with the modified-rigid-body-spring concrete model,in which the mechanical parameters derived from macro-scale material tests were applied directly to the mortar elements.By comparing the calculated results with those predicted by the Carpinteri andWeibull size effects laws,a series of formulas to convert the macro-scale mechanical parameters of mortar and interface to those at the meso-scale were proposed through a fitting analysis.Based on the proposed formulas,numerical simulation of axial compressive and tensile failure processes of concrete and cement mortar materials,respectively were conducted.The calculated results were a good match with the test results. 展开更多
关键词 CONCRETE meso-mechanical model discrete element method size effect mechanical parameter
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部