A visible-light-induced spirocyclizative hydroarylation via reductive dearomatization of a series of non activated arenes including 2-phenyl indoles and naphthalene derivatives under mild conditions is de scribed.An i...A visible-light-induced spirocyclizative hydroarylation via reductive dearomatization of a series of non activated arenes including 2-phenyl indoles and naphthalene derivatives under mild conditions is de scribed.An intriguing chemoselective dearomative hydroarylation of 2-phenyl indoles is presented.Th dearomative hydroarylation protocol rapidly delivers valuable spirocycles with carbon-carbon doub bonds from readily accessible aromatic precursors in a single step.展开更多
Visible-light-induced reductive dearomatization of nonactivated arenes is a very challenging transformation and remains in its infancy.Herein,we report a novel strategy to achieve a visible-light-induced spirocyclizat...Visible-light-induced reductive dearomatization of nonactivated arenes is a very challenging transformation and remains in its infancy.Herein,we report a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of nonactivated arenes including naphthalenyl-and phenyl-bearing aromatics with CO_(2) under mild conditions through a radical-polar crossover cascade(RPCC).This reductive dearomatization protocol rapidly delivers a broad range of spirocyclic and valuable carboxylic acid derivatives from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity.展开更多
基金the financial supports from the National Natural Science Foundation of China(Nos.22022111,21871257,21801240)the Natural Science Foundation of Fujian Province(No.2020J02008)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB20000000)。
文摘A visible-light-induced spirocyclizative hydroarylation via reductive dearomatization of a series of non activated arenes including 2-phenyl indoles and naphthalene derivatives under mild conditions is de scribed.An intriguing chemoselective dearomative hydroarylation of 2-phenyl indoles is presented.Th dearomative hydroarylation protocol rapidly delivers valuable spirocycles with carbon-carbon doub bonds from readily accessible aromatic precursors in a single step.
基金the financial support from NSFC(grant nos.21871257,22022111,and 21801240)the Natural Science Foundation of Fujian Province(grant no.2020J02008)the Strategic Priority Research Program of the Chinese Academy of Sciences(grant no.XDB20000000).
文摘Visible-light-induced reductive dearomatization of nonactivated arenes is a very challenging transformation and remains in its infancy.Herein,we report a novel strategy to achieve a visible-light-induced spirocyclizative remote arylcarboxylation of nonactivated arenes including naphthalenyl-and phenyl-bearing aromatics with CO_(2) under mild conditions through a radical-polar crossover cascade(RPCC).This reductive dearomatization protocol rapidly delivers a broad range of spirocyclic and valuable carboxylic acid derivatives from readily accessible aromatic precursors with generally good regioselectivity and chemoselectivity.
