As a powerful cell-based therapeutic approach,CAR-T therapy was originally designed for treating acquired immunodeficiency syndrome(AIDS)(Baker et al.,2023),but had been strikingly successful in curing hematologic mal...As a powerful cell-based therapeutic approach,CAR-T therapy was originally designed for treating acquired immunodeficiency syndrome(AIDS)(Baker et al.,2023),but had been strikingly successful in curing hematologic malignancies and multiple solid tumors.Numerous evidence has expanded the medical application of CAR-T therapy for the treatment of many other human diseases beyond cancer.In this article,we discuss the principle of CAR-T and enumerate the current application and limitation in oncology.Finally,we provide a comprehensive perspective of current advance and future directions of CAR-T in treating multiple non-tumoral diseases.展开更多
基金supported by the National Key Research and Development Program of China(Grant no.2019YFA0111400,2022YFE0200100)the National Natural Science Foundation of China(Grant no.32271165,82070144,82270155)the Interdisciplinary Project of Central Universities(Grant no.2022-2-ZD-02).
文摘As a powerful cell-based therapeutic approach,CAR-T therapy was originally designed for treating acquired immunodeficiency syndrome(AIDS)(Baker et al.,2023),but had been strikingly successful in curing hematologic malignancies and multiple solid tumors.Numerous evidence has expanded the medical application of CAR-T therapy for the treatment of many other human diseases beyond cancer.In this article,we discuss the principle of CAR-T and enumerate the current application and limitation in oncology.Finally,we provide a comprehensive perspective of current advance and future directions of CAR-T in treating multiple non-tumoral diseases.
