Autism spectrum disorder (ASD) is a complex developmental disability characterized by impaired social interaction and communication,restricted interests,and stereotypical behaviors [1,2].In addition to these core diag...Autism spectrum disorder (ASD) is a complex developmental disability characterized by impaired social interaction and communication,restricted interests,and stereotypical behaviors [1,2].In addition to these core diagnostic features,children with ASD frequently present with a host of associated behavioral issues,such as intellectual disability and epilepsy,as well as feeding and sleep problems.The prevalence of ASD in the United States is about 1/59,with a significantly higher proportion in males [3].Therefore,ASD is no longer a rare disorder.展开更多
Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accu...Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein synthesis.In the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation elongation.The activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).展开更多
In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is ...In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.展开更多
文摘Autism spectrum disorder (ASD) is a complex developmental disability characterized by impaired social interaction and communication,restricted interests,and stereotypical behaviors [1,2].In addition to these core diagnostic features,children with ASD frequently present with a host of associated behavioral issues,such as intellectual disability and epilepsy,as well as feeding and sleep problems.The prevalence of ASD in the United States is about 1/59,with a significantly higher proportion in males [3].Therefore,ASD is no longer a rare disorder.
基金The described work was supported by the National Natural Science Foundation of China(81730034 to J.H.,31671045 to Z.C.Z.,and 81901287 to Shuting Xia)the Natural Science Foundation of Jiangsu Province(BK20170080 to Z.C.Z.)Guangdong Key Project(2018B030335001 to J.H.).
文摘Protein synthesis involves initiation,elongation,and termination.A number of studies show that translation elongation is highly regulated and is the most energy-intensive process,which controls the efficiency and accuracy of protein synthesis.In the elongation process,eukaryotic elongation factor 2(eEF2)binds to the ribosome to induce its conformation change and promotes the translocation of the tRNAs by hydrolyzing guanosine triphosphate,which then allows the next AA-tRNA to enter the A site for translation elongation.The activity of eEF2 is negatively regulated by its kinase eEF2K that phosphorylates eEF2 at threonine-56(Thr56).
基金supported by the National Natural Science Foundation of China(31471031,31400927,and 31671045)the Natural Science Foundation of Jiangsu Province,China(BK20140623)
文摘In the past decade, numerous genes associated with autism spectrum disorders（ASDs） have been identified. These genes encode key regulators of synaptogenesis,synaptic function, and synaptic plasticity. Drosophila is a prominent model system for ASD studies to define novel genes linked to ASDs and decipher their molecular roles in synaptogenesis, synaptic function, synaptic plasticity, and neural circuit assembly and consolidation. Here, we review Drosophila studies on ASD genes that regulate synaptogenesis, synaptic function, and synaptic plasticity through modulating chromatin remodeling, transcription, protein synthesis and degradation, cytoskeleton dynamics, and synaptic scaffolding.
