Bacterial infection of cutaneous wounds can easily lead to occurrence of chronic wounds and even more serious diseases.Therefore,multifunctional,biodegradable,and reusable wound dressings that can quickly manage wound...Bacterial infection of cutaneous wounds can easily lead to occurrence of chronic wounds and even more serious diseases.Therefore,multifunctional,biodegradable,and reusable wound dressings that can quickly manage wound infection and promote wound healing are urgently desired.Herein,inspired by the“capturing and killing”action of Drosera peltata Thunb.,a biomimetic cellulose film was constructed to capture the bacteria(via the rough structure of the film)and kill them(via the combination of photodynamic therapy and chemotherapy)to promote wound tissue remodeling.The film(termed OBC-PR)was simply prepared by chemically crosslinking the oxidized bacterial cellulose(OBC)with polyhexamethylene guanidine hydrochloride(PHGH)and rose bengal(RB).Notably,it could effectively capture Escherichia coli and Staphylococcus aureus bacterial cells with capture efficiencies of~99%and~96%,respectively,within 10 min.Furthermore,the in vivo experiments showed that OBC-PR could effectively promote the macrophage polarization toward the M2 phenotype and adequately induce the reconstruction of blood vessels and nerves,thus promoting wound healing.This study provides a potential direction for designing multifunctional wound dressings for managing infected skin wounds in the future.展开更多
Silk fibroin （SF） from the Bombyx mori silkworm exhibits attractive potential applications as biomechanical materials, due to its unique mechanical and biological properties. This review outlines the structure and p...Silk fibroin （SF） from the Bombyx mori silkworm exhibits attractive potential applications as biomechanical materials, due to its unique mechanical and biological properties. This review outlines the structure and properties of SF, including of its biocompatibility and biodegradability. It highlights recent researches on the fabrication of various SF-based composites scaffolds that are promising for tissue engineering applications, and discusses synthetic methods of various SF-based composites scaffolds and valuable approaches for controlling cell behaviors to promote the tissue repair. The function of extracellular matrices and their interaction with cells are also reviewed here.展开更多
基金supported by the National Natural Science Foundation of China(32101916 and 22205166)the Natural Science Foundation of Jiangsu Province(BK20200619).
文摘Bacterial infection of cutaneous wounds can easily lead to occurrence of chronic wounds and even more serious diseases.Therefore,multifunctional,biodegradable,and reusable wound dressings that can quickly manage wound infection and promote wound healing are urgently desired.Herein,inspired by the“capturing and killing”action of Drosera peltata Thunb.,a biomimetic cellulose film was constructed to capture the bacteria(via the rough structure of the film)and kill them(via the combination of photodynamic therapy and chemotherapy)to promote wound tissue remodeling.The film(termed OBC-PR)was simply prepared by chemically crosslinking the oxidized bacterial cellulose(OBC)with polyhexamethylene guanidine hydrochloride(PHGH)and rose bengal(RB).Notably,it could effectively capture Escherichia coli and Staphylococcus aureus bacterial cells with capture efficiencies of~99%and~96%,respectively,within 10 min.Furthermore,the in vivo experiments showed that OBC-PR could effectively promote the macrophage polarization toward the M2 phenotype and adequately induce the reconstruction of blood vessels and nerves,thus promoting wound healing.This study provides a potential direction for designing multifunctional wound dressings for managing infected skin wounds in the future.
文摘Silk fibroin （SF） from the Bombyx mori silkworm exhibits attractive potential applications as biomechanical materials, due to its unique mechanical and biological properties. This review outlines the structure and properties of SF, including of its biocompatibility and biodegradability. It highlights recent researches on the fabrication of various SF-based composites scaffolds that are promising for tissue engineering applications, and discusses synthetic methods of various SF-based composites scaffolds and valuable approaches for controlling cell behaviors to promote the tissue repair. The function of extracellular matrices and their interaction with cells are also reviewed here.
