Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety...Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly（ethylene glycol）（PEG） and polydimethylsiloxane（PDMS） segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.展开更多
基金financially supported by the National Natural Science Foundation of China (No.81671792)National Key R&D program of China (No.2016YFC0104100)the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘Poly（vinyl chloride）（PVC） is one of the mostly produced plastics in the world and is widely used in single-use medical devices. However, the additives that are often necessary for PVC arouse concerns of its safety, thus quests the modifications of PVC itself. In this study, poly（ethylene glycol）（PEG） and polydimethylsiloxane（PDMS） segments were grafted onto PVC backbone in similar ways, and the chemical structures of the modified PVCs were characterized by Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis and differential scanning calorimetry. Moreover, the water contact angle, protein adsorption, platelet adhesion, cell attachment and proliferation on different material surfaces were studied and compared. It was found that both PEG and PDMS grafting yielded improvement on biocompatibility compared with bare PVC, while hydrophobic PDMS grafted PVC showed more effective on cell attachment and proliferation than that of hydrophilic PEG grafted PVC.
