Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almos...Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almost exclusively in young girls [1,2].Over 95%of RTT patients carry loss-of-function mutations in the X-linked MECP2gene,while the same mutations in males largely lead to infantile death.展开更多
文摘Methyl-CpG-binding protein 2 (MeCP2) is broadly recognized as the genetic cause of Rett Syndrome (RTT),a devastating neurodevelopmental disorder with the progressive loss in motor skills and speech that is found almost exclusively in young girls [1,2].Over 95%of RTT patients carry loss-of-function mutations in the X-linked MECP2gene,while the same mutations in males largely lead to infantile death.
