Objective:To summarize the recent 10 years of related literature on stem cell effect on aging and explore the research results and hot topics.Methods:Based on the core databaseof Web of Science,all relevant literature...Objective:To summarize the recent 10 years of related literature on stem cell effect on aging and explore the research results and hot topics.Methods:Based on the core databaseof Web of Science,all relevant literature from January 1,2012,to December 31,2021,was screened,and CiteSpace 6.1.R2 software was used to show the intrinsic value of literature.The number of publications,research institutions,research countries,co-cited literature,and keywords was analyzed and visualized.Results:In the past 10 years,the total number of articles published showed an upward trend.The number of articles published by relevant countries was 3,911,and the United States had the most significant number of articles published and the highest centrality.The research institutions were mainly universities,supplemented by research centers,and the quality of articles published by famous foreign universities in this field was high.The most co-cited literature is“Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan”by Darren J Baker,which clarifies the feasibility of cell therapy for aging.The high-frequency keywords are stem cell,senescence,expression,etc.,and the most central ones are cancer cell,migration and DNA repair,etc.In addition,emergent words and clustering show that research hotspots are mainly in the aging mechanism.There are many research entry points,and the pathogenesis and development of senescence,therapeutic targets of ion channels in senescent cells,and their effects on exosomes are the main focus of current research.Conclusion:Literature through the analysis of 10 years of research literature summary suggests that stem cell function in aging still needs further study;the United States is in the leading position in this regard,and the research results also show that research institutions dominate in the developed countries,North America and Europe in the increasing number of papers at the same time,and China should pay attention to the quality of the post,in order to make more progress.The literature of some high-quality scholars can be used as a reference to expand our thinking.The aging mechanism still needs to be many follow-upstudies to clarify the pathway and target in the treatment of more refined Alzheimer’s disease and other age-related diseases need to delve into.Subsequent scholars should study the specific role of stem cells in treating aging;in recent years,hot words,such as exosomes,oxidative stress,etc.,can be used as the thinking of the follow-up study and contribute to the development of the field.展开更多
文摘Objective:To summarize the recent 10 years of related literature on stem cell effect on aging and explore the research results and hot topics.Methods:Based on the core databaseof Web of Science,all relevant literature from January 1,2012,to December 31,2021,was screened,and CiteSpace 6.1.R2 software was used to show the intrinsic value of literature.The number of publications,research institutions,research countries,co-cited literature,and keywords was analyzed and visualized.Results:In the past 10 years,the total number of articles published showed an upward trend.The number of articles published by relevant countries was 3,911,and the United States had the most significant number of articles published and the highest centrality.The research institutions were mainly universities,supplemented by research centers,and the quality of articles published by famous foreign universities in this field was high.The most co-cited literature is“Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan”by Darren J Baker,which clarifies the feasibility of cell therapy for aging.The high-frequency keywords are stem cell,senescence,expression,etc.,and the most central ones are cancer cell,migration and DNA repair,etc.In addition,emergent words and clustering show that research hotspots are mainly in the aging mechanism.There are many research entry points,and the pathogenesis and development of senescence,therapeutic targets of ion channels in senescent cells,and their effects on exosomes are the main focus of current research.Conclusion:Literature through the analysis of 10 years of research literature summary suggests that stem cell function in aging still needs further study;the United States is in the leading position in this regard,and the research results also show that research institutions dominate in the developed countries,North America and Europe in the increasing number of papers at the same time,and China should pay attention to the quality of the post,in order to make more progress.The literature of some high-quality scholars can be used as a reference to expand our thinking.The aging mechanism still needs to be many follow-upstudies to clarify the pathway and target in the treatment of more refined Alzheimer’s disease and other age-related diseases need to delve into.Subsequent scholars should study the specific role of stem cells in treating aging;in recent years,hot words,such as exosomes,oxidative stress,etc.,can be used as the thinking of the follow-up study and contribute to the development of the field.
