Metastasis is not solely a consequence of autonomous tumor cell properties,but also significantly associated with the complex interaction between colonized tissues and tumor cells,as well as the site microenvironment....Metastasis is not solely a consequence of autonomous tumor cell properties,but also significantly associated with the complex interaction between colonized tissues and tumor cells,as well as the site microenvironment.Through the secretion of specific inflammatory mediators,primary tumors establish a favorable microenvironment for self-survival in the colonization tissues before metastasis,which is called pre-metastatic niche.This paper aims to review the regulatory mechanisms of pre-metastatic niche formation,in hope of providing strategies for the prevention of early tumors and targeted therapies of advanced tumors.展开更多
Cholangiocarcinoma(CCA)is one of the most common and highly malignant tumors,and its incidence and mortality rates are increasing yearly.Circular RNAs(circRNAs),a class of closed-loop non-coding RNAs formed by reverse...Cholangiocarcinoma(CCA)is one of the most common and highly malignant tumors,and its incidence and mortality rates are increasing yearly.Circular RNAs(circRNAs),a class of closed-loop non-coding RNAs formed by reverse splicing of exons or introns,play an essential regulatory role in CCA and have been a hot topic of medical research in recent years.In addition,about 80%of current research reports focus on the ability of circRNAs to sponge miRNAs in CCA.However,as research continues,circRNAs are more than just a sponge in CCA;they can also alter protein subcellular localization,encode proteins and affect other cells via extracellular vesicles(EVs).Interestingly,circRNAs not only serve as novel players in CCA pathogenesis but also as potential biomarkers and therapeutic targets for CCA.展开更多
基金Hong Kong Scholars Program(Grant No.XJ2020012)National Natural Science Foundation of China(Grant No.81902431)+8 种基金Outstanding Youth Project of Natural Science Foundation of Heilongjiang(Grant No.YQ2019H007)Special Project of China Postdoctoral Science Foundation(Grant No.2019T120279)Special Project of Heilongjiang Postdoctoral Science Foundation(Grant No.LBH-TZ1016)China Postdoctoral Science Foundation(Grant No.2018M641849 and 2018M640311)Heilongjiang Postdoctoral Science Foundation(Grant No.LBH-Z18107 and LBH-Z18112)The Fundamental Research Funds for the Heilongjiang Provincial Universities(Grant No.2018-KYYWF-0511 and 2018-KYYWF-0498)Postgraduate Innovative Research Project of Harbin Medical University(Grant No.YJSCX2016-21HYD)Foundation of Key Laboratory of Myocardial Ischemia,Ministry of Education(Grant No.KF201810)Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province(Grant No.CXPJJH11800004-001 and CXPJJH11800004-003).
文摘Metastasis is not solely a consequence of autonomous tumor cell properties,but also significantly associated with the complex interaction between colonized tissues and tumor cells,as well as the site microenvironment.Through the secretion of specific inflammatory mediators,primary tumors establish a favorable microenvironment for self-survival in the colonization tissues before metastasis,which is called pre-metastatic niche.This paper aims to review the regulatory mechanisms of pre-metastatic niche formation,in hope of providing strategies for the prevention of early tumors and targeted therapies of advanced tumors.
基金Hong Kong Scholars Program(No.XJ2020012)National Natural Science Foundation of China(No.81902431)+13 种基金Excellent Young Scientists Project of Natural Science Foundation of Heilongjiang Province(No.YQ2019H007)Special Project of China Postdoctoral Science Foundation(No.2019T120279)Special Project of Heilongjiang Postdoctoral Science Foundation(No.LBH-TZ1016)China Postdoctoral Science Foundation(No.2018M641849)Heilongjiang Postdoctoral Science Foundation(No.LBH-Z18107)The Fundamental Research Funds for the Heilongjiang Provincial Universities(No.2018-KYYWF-0511)Beijing Xisike Clinical Oncology Research Foundation(No.Y-Young2022-0188)Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province(No.CXPJJH11800004-001)2022 Higher Education Science Research Planning Project of China Association of Higher Education(No.22CX0405)Postgraduate Innovative Research Project of Harbin Medical University(No.YJSCX2016-21HYD)Opening Project of Key Laboratory of Myocardial Ischemia,Ministry of Education(No.KF201810)Opening Project of Key Laboratory of Functional and Clinical Translational Medicine,Fujian Province University(No.XMMC-FCTM202205)Opening Project of Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials(No.JETNM202210)Medjaden Academy&Research Foundation for Young Scientists(No.MJR20220903).
文摘Cholangiocarcinoma(CCA)is one of the most common and highly malignant tumors,and its incidence and mortality rates are increasing yearly.Circular RNAs(circRNAs),a class of closed-loop non-coding RNAs formed by reverse splicing of exons or introns,play an essential regulatory role in CCA and have been a hot topic of medical research in recent years.In addition,about 80%of current research reports focus on the ability of circRNAs to sponge miRNAs in CCA.However,as research continues,circRNAs are more than just a sponge in CCA;they can also alter protein subcellular localization,encode proteins and affect other cells via extracellular vesicles(EVs).Interestingly,circRNAs not only serve as novel players in CCA pathogenesis but also as potential biomarkers and therapeutic targets for CCA.
