四逆散“异病同治”的网络药理学作用机制文献综述

目的 基于发表的网络药理学研究探讨四逆散对肝癌、慢性肝炎、脂肪肝、桥本甲状腺炎等疾病“异病同治”的作用机制。方法 检索四逆散网络药理学研究,提取四逆散对应各种疾病的活性成分、作用靶点、作用通路。采用Microsoft Excel表格绘制成分-中药-疾病表、靶点-疾病表、通路-疾病表并进行描述性分析。结果 共纳入四逆散网络药理学研究20篇,4味中药材对应14种疾病的活性成分有244种,前10位活性成分为山奈酚、异鼠李素、槲皮素,芍药苷、刺芒柄花素、柚皮素、异橙黄酮、丁子香萜、茵陈黄酮、荜澄茄素。对应的靶点和通路分别为243种和395种,其中VEGFA、IL-6、EGFR、CCND1、CASP3、STAT3、PPARG、ICAM1、FOS、CYP3A4等关键靶点通过调控TNF信号通路、Toll样受体信号通路、PI3K-Akt信号通路、HIF-1信号通路、膜筏通路等重要通路来发挥作用。结论 四逆散通过多成分、多靶点、多通路对14种疾病具有治疗功效,本研究为进一步探究四逆散“异病同治”的作用机制提供了新的线索。

Microstructural evolution,mechanical properties and degradation mechanism of PS-PVD quasi-columnar thermal barrier coatings exposed to glassy CMAS deposits

Thermal barrier coatings(TBCs) applied in aeroengines tend to be attacked by molten calcia-magnesiaalumino-silicate(CMAS) at high operating temperatures.Yttria-stabilized zirconia(YSZ) coatings with quasicolumnar microstructure were fabricated by plasma spray physical vapor deposition(PS-PVD) technique.The chemic al changes,micros tructural transform ation,mechanical properties and degradation mechanisms of the CM AS-interacted TBCs in the thermal cycling tests were investigated.Feathered YSZ grains were dissolved in the CMAS melts,and then the ZrO_(2) grains were reprecipitated with spherical shape,accompanying with phase transformation from tetragonal(t) to monoclinic(m).The thermal cycling tests reveal that the YSZ coating fails at the early stage due to the attack of CMAS.The fractures in intracolumns lead to partial spallation of the coatings.The failure of the coating occurs at the interfaces between thermally grown oxides(TGO) layer and YSZ topcoat;especially,the hardness and Young's modulus of the YSZ coatings increase intensively,as the coatings were infiltrated by the CMAS for a long time.