An improved and efficient method for synthesis of (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reacti...An improved and efficient method for synthesis of (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reactions were in mild conditions, and the title compound I was accomplished in six steps in overall yield of 70%.展开更多
文摘An improved and efficient method for synthesis of (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane (1) from trans-4-hydroxy-L-proline was developed. Using benzyloxycarbonyl (Cbz) as protection group of amine, the reactions were in mild conditions, and the title compound I was accomplished in six steps in overall yield of 70%.