Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications

Diabetes mellitus(DM)is one of the major causes of mortality worldwide,with inflammation being an important factor in its onset and development.This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway in mediating inflammatory responses.Furthermore,it compre-hensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM,diabetic gastroenteropathy,diabetic cardiomyopathy,non-alcoholic fatty liver disease,and other complic-ations.Additionally,the role of cGAS-STING in autonomic dysfunction and intes-tinal dysregulation,which can lead to digestive complications,has been discuss-ed.Altogether,this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

New multi-camera calibration algorithm based on 1D objects

A new calibration algorithm for multi-camera systems using 1D calibration objects is proposed. The algorithm inte- grates the rank-4 factorization with Zhang (2004)'s method. The intrinsic parameters as well as the extrinsic parameters are re- covered by capturing with cameras the 1D object's rotations around a fixed point. The algorithm is based on factorization of the scaled measurement matrix, the projective depth of which is estimated in an analytical equation instead of a recursive form. For more than three points on a 1D object, the approach of our algorithm is to extend the scaled measurement matrix. The obtained parameters are finally refined through the maximum likelihood inference. Simulations and experiments with real images verify that the proposed technique achieves a good trade-off between the intrinsic and extrinsic camera parameters.

Design of Power Supply for On-line Monitoring System of Transmission Lines

This paper uses CT to gain the energy directly from the high-voltage transmission line, to address the problem of power supply for monitoring system in high voltage side of transmission line. The draw-out power coil can induce voltage from the transmission line, using single-chip microcomputer to analog and output PMW wave to control the charging module, provides a stable 3.4 V DC voltage to the load, and solve the problem of easy saturating of core. The power supply based on this kind of draw-out power coil has undergone the overall testing, and it is verified-showing that it can properly work in a non-saturated status within the current range of 50 - 1000 A, and provide a stable output. The equipment also design protection circuit to improve the reliability to avid the impacts of the impulse current or short-circuit current. It effectively solves the problem of power supply for On-line Monitoring System of Transmission.

Impact of the cold surge event in January 2021 on the power system of China

During 6-10 January 2021,a recorded strong cold surge took place in China,with over 800 observational stations reaching their historical extremes.Unlike previous studies that focused on the response of either the power load or generation separately,this study quantitatively revealed the impacts on the balance between the demand and supply sides of the grid.On the demand side,the sensitivity of power load was found to increase substantially higher in southern China(0.533 GW°C^(−1))than in the northern region(0.139 GW°C^(−1))due to the limited municipal heating system.On the supply side,the hourly wind power generation dropped from the highest of 110 GW on 6 January to the lowest of 54 GW on 9 January due to the reduction in wind speed.In addition,a reduction in solar power generation was observed during 8-10 January.Thus,the balance of the power system was influenced by this cold event.As an effective adaptation measure,results further showed that early warning by three weeks ahead can be obtained by an operational climate model.The sensitivity of China's power system to such cold surge events may increase remarkably due to the expected increase in the proportion of wind and solar power generation in future new-type power systems.Thus,close cooperation between climate scientists and power engineers is needed to build the resilience of the power system to the cold extremes.