This paper considers the random coefficient autoregressive model with time-functional variance noises,hereafter the RCA-TFV model.We first establish the consistency and asymptotic normality of the conditional least sq...This paper considers the random coefficient autoregressive model with time-functional variance noises,hereafter the RCA-TFV model.We first establish the consistency and asymptotic normality of the conditional least squares estimator for the constant coefficient.The semiparametric least squares estimator for the variance of the random coefficient and the nonparametric estimator for the variance function are constructed,and their asymptotic results are reported.A simulation study is presented along with an analysis of real data to assess the performance of our method in finite samples.展开更多
To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A gene...To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function(LOF)variants was strongly associated with the pronounced reductions in serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels,[2,3]suggesting that ASGR1 may play a key role in cholesterol metabolism.However,the function of ASGR1 remains largely unclear.This study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52338009)the National Science Fund for Distinguished Young Scholars(Grant No.52025085)+4 种基金the Graduate Research Innovation Project of Hunan Province(Grant No.CX20220952)Xiaohui Liu’s research is supported by the NSF of China(Grant No.11971208)the National Social Science Foundation of China(Grant No.21&ZD152)the Outstanding Youth Fund Project of the Science and Technology Department of Jiangxi Province(Grant No.20224ACB211003)the NSF of China(Grant No.92358303).
文摘This paper considers the random coefficient autoregressive model with time-functional variance noises,hereafter the RCA-TFV model.We first establish the consistency and asymptotic normality of the conditional least squares estimator for the constant coefficient.The semiparametric least squares estimator for the variance of the random coefficient and the nonparametric estimator for the variance function are constructed,and their asymptotic results are reported.A simulation study is presented along with an analysis of real data to assess the performance of our method in finite samples.
基金This work was supported by grants from the Natural Science Foundation of Hunan Province in China(Nos.2017JJ3250 and 2019JJ40230)the Science and Technology Plan Project of the Health commission of Hunan Province in China(Nos.B2019034 and B2019035).
文摘To the Editor:Asialoglycoprotein receptor 1(ASGR1)is the major subunit of ASGR,it is predominantly expressed by liver parenchymal cells and relatively lower expression was found in peripheral blood monocytes.[1]A genetic study recently revealed that ASGR1 haploinsufficiency resulted from loss-of-function(LOF)variants was strongly associated with the pronounced reductions in serum total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)levels,[2,3]suggesting that ASGR1 may play a key role in cholesterol metabolism.However,the function of ASGR1 remains largely unclear.This study was focused on the association of ASGR1 gene expression in monocytes and plasma cholesterol level.
