Source analysis of dissolved heavy metals in the Shaying River Basin,China

Over the years,the Shaying River Basin has experienced frequent instances of river pollution.The presence of numerous critical pollutant discharge enterprises and sewage-treatment plants in the vicinity of the Shaying River has transformed it a major tributary with relatively serious pollution challenge within the upper reaches of Huaihe River Basin.To study the sources of manganese(Mn),chromium(Cr),nickel(Ni),arsenic(As),cadmium(Cd)and lead(Pb)in Shaying River water,123 sets of surface water samples were collected from 41 sampling points across the entire basin during three distinct phases from 2019 to 2020,encompassing normal water period,dry season and wet season.The primary origins of heavy metals in river water were determined by analyzing the heavy metal contents in urban sewage wastewater,industrial sewage wastewater,groundwater,mine water,and the heavy metal contributions from agricultural non-point source pollution.The analytical findings reveal that Mn primarily originates from shallow groundwater used for agricultural irrigation,While Cr mainly is primarily sourced from urban sewage treatment plant effluents,coal washing wastewater,tannery wastewater,and industrial discharge related to metal processing and manufacturing.Ni is mainly contributed by urban sewage treatment plant effluents and industrial wastewater streams associated with machinery manufacturing and metal processing.Cd primarily linked to industrial wastewater,particularly from machinery manufacturing and metal processing facilities,while Pb is predominantly associated with urban sewage treatment plant effluents and wastewater generated in Pb processing and recycling wastewater.These research provides a crucial foundation for addressing the prevention and control of dissolved heavy metals at their sources in the Shaying River.

AIWW:a new nutrition-screening tool for the oncologic population

Malnutrition is a common comorbidity among patients with cancer.However,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is needed.Based on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each category.According to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on PG-SGA.Based on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,respectively.The sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and 0.975.The Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,respectively.The area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,respectively.The IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with cancer.The missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,respectively.AIWW showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool for this population.

A case on acupuncture for Wilson disease

Wilson disease(WD),an autosomal recessive disease with abnormal copper metabolism,is caused by mutations in the ATP7 B gene.The symptoms are characterized by liver,nervous system,and ocular manifestations related to the deposition of copper in the liver,lens nucleus,and cornea.The case reported in this article was a 30-year-old woman with high muscle tension,unable to stand or walk,low voice,and short-term memory loss.Brain MRI showed that patchy Tl,long T2 signals,and high FLAIR presented signals in the basal ganglia thalamus area,subcortex,and brain stem.Low signal shadows were presented in magnetically sensitive bilateral basal ganglia region,callus,and cerebellar dentate nucleus.Ceruloplasmin was significantly reduced.With conventional treatments by western medicine,the symptoms were not alleviated.However,after the application of acupuncture-assisted treatment,the patient is capable with self-care ability,thus a desired effect was achieved.It is therefore suggested that acupuncture shall be applied to assist the treatment of WD to relieve symptoms and help patients regain self-care ability.