Background and Aims: Transmural healing (TH) has been recently proposed as a measure of deep remission in Crohn’s disease (CD). This study aimed to explore the rate of TH evaluated by intestinal ultrasound (IUS) in p...Background and Aims: Transmural healing (TH) has been recently proposed as a measure of deep remission in Crohn’s disease (CD). This study aimed to explore the rate of TH evaluated by intestinal ultrasound (IUS) in patients with CD treated with infliximab (IFX) and its predictive value for long-time clinical remission. Methods: Sixty-four consecutive active CD patients prescribed IFX were retrospectively recruited and followed for at least 2 years. Patients underwent IUS evaluation including bowel wall thickness, stratification, vascularity and mesenteric fat alteration at baseline and 14 weeks after IFX initiation. TH (normalization of all IUS parameters) was assessed at 14 weeks. Results: Fifteen (23.4%) patients achieved TH at 14 weeks, who were at lower risk of clinical relapse during the maintenance period than patients without TH [relative risk (RR) 0.132, P = 0.020]. The multivariate analysis indicated that TH (RR = 0.076, 95% CI: 0.007 - 0.773, P = 0.029) at 14 weeks were negative independent predictors of clinical relapse for patients who achieved steroid-free CR after the induction period. Patients with serum IFX trough levels >3 ug/ml were more likely to achieve TH at 14 weeks (34.3% vs. 10.7%, P = 0.029). Conclusion: IUS is useful in assessing TH, which predicts long-term clinical remission in patients with CD prescribed infliximab.展开更多
This paper makes an empirical analysis of the spatial spillover effect of regional economic growth by using Moran’s I and Spatial Durbin Model to study the input and output of technological progress, with the panel d...This paper makes an empirical analysis of the spatial spillover effect of regional economic growth by using Moran’s I and Spatial Durbin Model to study the input and output of technological progress, with the panel data of 21 prefecture-level cities in Guangdong Province from 2008 to 2017. The empirical results show that the spatial autocorrelation exists in the economic development of Guangdong Province, and both the input and output of scientific research innovation have a significant positive effect on the regional economic growth. Under the spatial contiguity weights matrix, the output of scientific research and innovation has a more obvious spillover effect on the economic growth of neighboring cities than the input of scientific research and innovation.展开更多
Introduction Bowel stricture is a common complication in patients with Crohn’s disease(CD),which often requires surgery[1,2].Notably,25%of patients develop at least one small bowel stricture[3].Endoscopic interventio...Introduction Bowel stricture is a common complication in patients with Crohn’s disease(CD),which often requires surgery[1,2].Notably,25%of patients develop at least one small bowel stricture[3].Endoscopic intervention has emerged as a feasible and minimally invasive adjunct or alternative to surgery.However,endoscopic intervention for small bowel strictures poses a technical challenge for gastroenterologists.Deep small bowel strictures beyond the terminal ileum are only accessible to device-assisted enteroscopy,including balloon-assisted enteroscopy(BAE).BAE-based endoscopic balloon dilation(EBD)has been reported to be safe and effective for small bowel strictures from CD[4].展开更多
文摘Background and Aims: Transmural healing (TH) has been recently proposed as a measure of deep remission in Crohn’s disease (CD). This study aimed to explore the rate of TH evaluated by intestinal ultrasound (IUS) in patients with CD treated with infliximab (IFX) and its predictive value for long-time clinical remission. Methods: Sixty-four consecutive active CD patients prescribed IFX were retrospectively recruited and followed for at least 2 years. Patients underwent IUS evaluation including bowel wall thickness, stratification, vascularity and mesenteric fat alteration at baseline and 14 weeks after IFX initiation. TH (normalization of all IUS parameters) was assessed at 14 weeks. Results: Fifteen (23.4%) patients achieved TH at 14 weeks, who were at lower risk of clinical relapse during the maintenance period than patients without TH [relative risk (RR) 0.132, P = 0.020]. The multivariate analysis indicated that TH (RR = 0.076, 95% CI: 0.007 - 0.773, P = 0.029) at 14 weeks were negative independent predictors of clinical relapse for patients who achieved steroid-free CR after the induction period. Patients with serum IFX trough levels >3 ug/ml were more likely to achieve TH at 14 weeks (34.3% vs. 10.7%, P = 0.029). Conclusion: IUS is useful in assessing TH, which predicts long-term clinical remission in patients with CD prescribed infliximab.
文摘This paper makes an empirical analysis of the spatial spillover effect of regional economic growth by using Moran’s I and Spatial Durbin Model to study the input and output of technological progress, with the panel data of 21 prefecture-level cities in Guangdong Province from 2008 to 2017. The empirical results show that the spatial autocorrelation exists in the economic development of Guangdong Province, and both the input and output of scientific research innovation have a significant positive effect on the regional economic growth. Under the spatial contiguity weights matrix, the output of scientific research and innovation has a more obvious spillover effect on the economic growth of neighboring cities than the input of scientific research and innovation.
基金supported in part by the National Natural Science Foundation of China[grant numbers 81870382,82100544]Guangdong Basic and Applied Basic Research Foundation[grant number 2020A1515111102]+2 种基金China Postdoctoral Science Foundation[grant number 2021M703743]Postdoctoral Foundation of the Sixth Hospital of Sun Yat-sen University[grant number R20210217202112997]National Key Clinical Discipline.
文摘Introduction Bowel stricture is a common complication in patients with Crohn’s disease(CD),which often requires surgery[1,2].Notably,25%of patients develop at least one small bowel stricture[3].Endoscopic intervention has emerged as a feasible and minimally invasive adjunct or alternative to surgery.However,endoscopic intervention for small bowel strictures poses a technical challenge for gastroenterologists.Deep small bowel strictures beyond the terminal ileum are only accessible to device-assisted enteroscopy,including balloon-assisted enteroscopy(BAE).BAE-based endoscopic balloon dilation(EBD)has been reported to be safe and effective for small bowel strictures from CD[4].
