To the Editor:Asthma is a complex chronic inflammatory lung disease,and its pathogenesis is not fully understood.It is believed that airway epithelium primarily acts as a defensive barrier to protect the lung from all...To the Editor:Asthma is a complex chronic inflammatory lung disease,and its pathogenesis is not fully understood.It is believed that airway epithelium primarily acts as a defensive barrier to protect the lung from allergens,avoiding the asthma.The integrity of the airway epithelial barrier is dependent on tight junctions comprised of zona occludens(ZO)1 to 3,occludin,and claudin 1 to 5,and adherens junctions mainly formed by E-cadherin,b-catenin,and junctional adhesion molecule,which maintain apicobasal polarity of bronchial epithelial cells.展开更多
基金National Natural Science Foundation of China(Nos.81970032 and 81870026)
文摘To the Editor:Asthma is a complex chronic inflammatory lung disease,and its pathogenesis is not fully understood.It is believed that airway epithelium primarily acts as a defensive barrier to protect the lung from allergens,avoiding the asthma.The integrity of the airway epithelial barrier is dependent on tight junctions comprised of zona occludens(ZO)1 to 3,occludin,and claudin 1 to 5,and adherens junctions mainly formed by E-cadherin,b-catenin,and junctional adhesion molecule,which maintain apicobasal polarity of bronchial epithelial cells.
