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Bioprinted mesenchymal stem cell microfiber-derived extracellular vesicles alleviate unilateral renal ischemia-reperfusion injury and fibrosis by inhibiting tubular epithelial cells ferroptosis
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作者 Qiang Guo Jianwei Chen +9 位作者 Jianjian Wu zijun mo Lei Ye Wenwen Zhong Yi Zhang Huajian Lai Yifei Zhang Jianguang Qiu Tao Xu Dejuan Wang 《Bioactive Materials》 SCIE CSCD 2024年第10期649-664,共16页
Renal unilateral ischemia-reperfusion injury(UIRI)constitutes a significant global health challenge,with poor recovery leading to chronic kidney disease and subsequent renal fibrosis.Extracellular vesicles(EVs)present... Renal unilateral ischemia-reperfusion injury(UIRI)constitutes a significant global health challenge,with poor recovery leading to chronic kidney disease and subsequent renal fibrosis.Extracellular vesicles(EVs)present substantial potential benefits for renal diseases.However,the limited yield and efficacy of EVs produced through traditional methodologies(2D-EVs)severely restrict their widespread application.Moreover,the efficient and effective strategies for using EVs in UIRI treatment and their mechanisms remain largely unexplored.In this study,we propose an innovative approach by integrating bioprinted mesenchymal stem cell microfiber extracellular vesicles production technology(3D-EVs)with a tail vein injection method,introducing a novel treatment strategy for UIRI.Our comparison of the biological functions of 2D-EVs and 3D-EVs,both in vitro and in vivo,reveals that 3D-EVs significantly outperform 2D-EVs.Specifically,in vitro,3D-EVs demonstrate a superior capacity to enhance the proliferation and migration of NRK-52E cells and mitigate hypoxia/reoxygenation(H/R)-induced injuries by reducing epithelial-mesenchymal transformation,extracellular matrix deposition,and ferroptosis.In vivo,3D-EVs exhibit enhanced therapeutic effects,as evidenced by improved renal function and decreased collagen deposition in UIRI mouse kidneys.We further elucidate the mechanism by which 3D-EVs derived from KLF15 ameliorate UIRI-induced tubular epithelial cells(TECs)ferroptosis through the modulation of SLC7A11 and GPX4 expression.Our findings suggest that bioprinted mesenchymal stem cells microfiberderived EVs significantly ameliorate renal UIRI,opening new avenues for effective and efficient EV-based therapies in UIRI treatment. 展开更多
关键词 Bioprinted 3D-EVs Unilateral renal ischemia-reperfusion injury KLF15 Ferroptosis
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Corrigendum to“Synergistically targeting synovium STING pathway for rheumatoid arthritis treatment”[Bioact Mater 24(2022)37–53]
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作者 Qiang Guo Jianwei Chen +9 位作者 Jianjian Wu zijun mo Lei Ye Wenwen Zhong Yi Zhang Huajian Lai Yifei Zhang Jianguang Qiu Tao Xu Dejuan Wang 《Bioactive Materials》 SCIE CSCD 2024年第10期665-666,共2页
The authors regret that two images in Fig.3A were originally misplaced by a careless mistake.The corrected versions of these images are provided below.These corrections do not alter any findings and conclusions report... The authors regret that two images in Fig.3A were originally misplaced by a careless mistake.The corrected versions of these images are provided below.These corrections do not alter any findings and conclusions reported in this article.No additional text corrections are needed in the article.The authors would like to apologise for any inconvenience caused. 展开更多
关键词 correction finding MISTAKE
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