The May 222021 M_(W)7.4 Madoi,Qinghai,China earthquake presented a rare opportunity to apply the modern unmanned aerial vehicle(UAV)photography method in extreme altitude and weather conditions to image surface ruptur...The May 222021 M_(W)7.4 Madoi,Qinghai,China earthquake presented a rare opportunity to apply the modern unmanned aerial vehicle(UAV)photography method in extreme altitude and weather conditions to image surface ruptures and near-field effects of earthquake-related surface deformations in the remote Tibet.High-resolution aerial photographs were acquired in the days immediately following the mainshock.The complex surface rupture patterns associated with this event were covered comprehensively at 3-6 cm resolution.This effort represents the first time that an earthquake rupture in the interior of the Qinghai-Tibetan Plateau has been fully and systematically captured by such high-resolution imagery,with an unprecedented level of detail,over its entire length.The dataset has proven valuable in documenting subtle and transient rupture features,such as the significant mole-tracks and opening fissures,which were ubiquitous coseismically but degraded during the subsequent summer storm season.Such high-quality imagery also helps to document with high fidelity the fractures of the surface rupture zone(supplements of this paper),the pattern related to how the faults ruptured to the ground surface,and the distribution of off-fault damage.In combination with other ground-based mapping efforts,the data will be analyzed in the following months to better understand the mechanics of earthquake rupture related to the fault zone rheology,rupture dynamics,and frictional properties along with the fault interface.展开更多
Ni-Al mixed metal oxides have been successfully prepared by high shear mixer(HSM)and coprecipitation(CP)methods for low temperature CO methanation.In this work,Ni-Al(HSM-CP)catalyst presented small Ni crystallite size...Ni-Al mixed metal oxides have been successfully prepared by high shear mixer(HSM)and coprecipitation(CP)methods for low temperature CO methanation.In this work,Ni-Al(HSM-CP)catalyst presented small Ni crystallite size and high surface area,which all contribute to the methanation reaction at low temperature conditions.The obtained Ni-Al(HSM-CP)sample exhibited a mass of defective oxygen,thereby accelerating the dissociation of CO and ultimately increasing the activity of the catalyst.Ni-Al(HSM-CP)catalyst offered the best activity with CO conversion=100%and CH_(4) selectivity=93%at 300℃,and the CH_(4) selectivity can reach 81.8%at 200℃.In situ Fourier transform infrared spectroscopy and density functional theory show that CHO and COH intermediates with lower activation energy barriers are produced during the reaction,and hydrogen-assisted carbon–oxygen bond scission is more favorable.展开更多
Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)systems.As an efcient fber-integrated WOPT system typically uses a 1550 nm las...Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)systems.As an efcient fber-integrated WOPT system typically uses a 1550 nm laser beam,it is essential to tune the peak conversion efciency of IRPCs to this wavelength.However,IRPCs based on lead sulfde(PbS)colloidal quantum dots(CQDs)with an excitonic peak of 1550 nm exhibit low short circuit current(Jsc)due to insufcient absorption under monochromatic light illumination.Here,we propose comprehensive optical engineering to optimize the device structure of IRPCs based on PbS CQDs,for 1550 nm WOPT systems.The absorption by the device is enhanced by improving the transmittance of tin-doped indium oxide(ITO)in the infrared region and by utilizing the optical resonance efect in the device.Therefore,the optimized device exhibited a high short circuit current density of 37.65 mA/cm^(2)under 1 sun(AM 1.5G)solar illumination and 11.91 mA/cm^(2)under 1550 nm illumination 17.3 mW/cm^(2).Furthermore,the champion device achieved a record high power conversion efciency(PCE)of 7.17%under 1 sun illumination and 10.29%under 1550 nm illumination.The PbS CQDs IRPCs under 1550 nm illumination can even light up a liquid crystal display(LCD),demonstrating application prospects in the future.展开更多
Hypertension,also known as high blood pressure,is a serious medical condition that may cause severe health problems,such as heart attack and stroke.According to the World Health Organization(WHO),^([1])an estimated 1....Hypertension,also known as high blood pressure,is a serious medical condition that may cause severe health problems,such as heart attack and stroke.According to the World Health Organization(WHO),^([1])an estimated 1.28 billion adults worldwide aged 30–79 years had hypertension in 2021,two-third of whom were living in low-and middle-income countries.Many national and international clinical practice guidelines(CPGs)on the diagnosis,evaluation,and treatment of hypertension have been published to promote its control.Among these,comprehensive hypertension guidelines provide broader direction to more target users,especially primary healthcare practitioners,than“narrow”types of guidelines.展开更多
In this work, graphene oxide(GO) nanosheets with surface modification by Tannic and Fe coordination complexes(TA-Fe) were incorporated into poly(vinylidene fluoride)(PVDF) to prepare high constant but low loss polymer...In this work, graphene oxide(GO) nanosheets with surface modification by Tannic and Fe coordination complexes(TA-Fe) were incorporated into poly(vinylidene fluoride)(PVDF) to prepare high constant but low loss polymer nanocomposites, and the effect of TA-Fe interlayer on dielectric properties of the GO@TA-Fe/PVDF nanocomposites was investigated. The results indicate that the dosage, mixing ratio, and reaction time of TA-Fe complexes have obvious influences on the dielectric properties of the nanocomposites. Furthermore, the TA-Fe interlayer significantly influences the electrical properties of GO@TA-Fe nanoparticles and their PVDF composites, and the GO@TA-Fe/PVDF composites exhibit superior dielectric properties compared with raw GO/PVDF. Dielectric losses of the GO@TA-Fe/PVDF are significantly suppressed to a rather low level owing to the presence of TA-Fe layer, which serves as an interlayer between the GO sheets, thus preventing them from direct contacting with each other. Additionally, the dynamic dielectric relaxation of the GO/PVDF and GO@TA-Fe/PVDF nanocomposites was investigated in terms of temperature.展开更多
Background.Hundreds of coronavirus disease 2019(COVID-19)clinical practice guidelines(CPGs)and expert consensus statements have been developed and published since the outbreak of the epidemic.However,these CPGs are of...Background.Hundreds of coronavirus disease 2019(COVID-19)clinical practice guidelines(CPGs)and expert consensus statements have been developed and published since the outbreak of the epidemic.However,these CPGs are of widely variable quality.So,this review is aimed at systematically evaluating the methodological and reporting qualities of COVID-19 CPGs,exploring factors that may influence their quality,and analyzing the change of recommendations in CPGs with evidence published.Methods.We searched five electronic databases and five websites from 1 January to 31 December 2020 to retrieve all COVID-19 CPGs.The assessment of the methodological and reporting qualities of CPGs was performed using the AGREE II instrument and RIGHT checklist.Recommendations and evidence used to make recommendations in the CPGs regarding some treatments for COVID-19(remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir)were also systematically assessed.And the statistical inference was performed to identify factors associated with the quality of CPGs.Results.We included a total of 92 COVID-19 CPGs developed by 19 countries.Overall,the RIGHT checklist reporting rate of COVID-19 CPGs was 33.0%,and the AGREE II domain score was 30.4%.The overall methodological and reporting qualities of COVID-19 CPGs gradually improved during the year 2020.Factors associated with high methodological and reporting qualities included the evidence-based development process,management of conflicts of interest,and use of established rating systems to assess the quality of evidence and strength of recommendations.The recommendations of only seven(7.6%)CPGs were informed by a systematic review of evidence,and these seven CPGs have relatively high methodological and reporting qualities,in which six of them fully meet the Institute of Medicine(IOM)criteria of guidelines.Besides,a rapid advice CPG developed by the World Health Organization(WHO)of the seven CPGs got the highest overall scores in methodological(72.8%)and reporting qualities(83.8%).Many CPGs covered the same clinical questions(it refers to the clinical questions on the effectiveness of treatments of remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavirritonavir in COVID-19 patients)and were published by different countries or organizations.Although randomized controlled trials and systematic reviews on the effectiveness of treatments of remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir for patients with COVID-19 have been published,the recommendations on those treatments still varied greatly across COVID-19 CPGs published in different countries or regions,which may suggest that the CPGs do not make sufficient use of the latest evidence.Conclusions.Both the methodological and reporting qualities of COVID-19 CPGs increased over time,but there is still room for further improvement.The lack of effective use of available evidence and management of conflicts of interest were the main reasons for the low quality of the CPGs.The use of formal rating systems for the quality of evidence and strength of recommendations may help to improve the quality of CPGs in the context of the COVID-19 pandemic.During the pandemic,we suggest developing a living guideline of which recommendations are supported by a systematic review for it can facilitate the timely translation of the latest research findings to clinical practice.We also suggest that CPG developers should register the guidelines in a registration platform at the beginning for it can reduce duplication development of guidelines on the same clinical question,increase the transparency of the development process,and promote cooperation among guideline developers all over the world.Since the International Practice Guideline Registry Platform has been created,developers could register guidelines prospectively and internationally on this platform.展开更多
What is already known about this topic?Wulanchabu City Center for Endemic Disease Prevention and Control had established and used a Brucellosis Integrated Information System(BIIS)since 2013.However,it had not been sys...What is already known about this topic?Wulanchabu City Center for Endemic Disease Prevention and Control had established and used a Brucellosis Integrated Information System(BIIS)since 2013.However,it had not been systematically evaluated and promoted so far.What is added by this report?The BIIS had significantly improved the efficiency of brucellosis reporting and provided convenience for follow-up management of cases,which was valuable for finishing completely routine therapy.However,the stability of the system needs to be improved.What are the implications for public health practice?The results of the BIIS assessment demonstrated its advantages and disadvantages,which could provide some evidence for its implementation in other areas of China.展开更多
In this study,we use eight pairs of commodity futures data to investigate the impact of the recently launched nighttime trading session by Chinese futures exchanges.We conduct a thorough empirical analysis on the cros...In this study,we use eight pairs of commodity futures data to investigate the impact of the recently launched nighttime trading session by Chinese futures exchanges.We conduct a thorough empirical analysis on the cross-market information transmission mechanisms between China and the U.S.We apply various econometric analyses including the co-integration analysis,the forecast error variance decomposition analysis,and the volatility spillover analysis with a bivariate GARCH model.Findings in this study indicate that,after the launching of nighttime-trading hours in China,the price discovery function of the Chinese futures market is noticeably improved,and that the Chinese market began to dominate the U.S.market in the bidirectional volatility spillover process.Thus,the introduction of the nighttime-trading hours appears to be an effective step toward China’s long-term goal of establishing pricing power in key commodities on the global financial market.展开更多
Fluorescence imaging in the second infrared window(1000-1700 nm)has emerged as a promising approach to tumor diagnosis.However,the currently available second near-infrared(NIR-II)imaging agents are based on the“alway...Fluorescence imaging in the second infrared window(1000-1700 nm)has emerged as a promising approach to tumor diagnosis.However,the currently available second near-infrared(NIR-II)imaging agents are based on the“always on”modality or single biomarker activation,which are subject to limited imaging contrast,nonspecific response,and even false-positive diagnosis.Here,we developed a H2S/H+dual-stimuli responsive NIR-II fluorescent probe,WH-N3,for precise tumor delimitation and intraoperative fluorescence-guided surgical resection.WH-N3 itself is nonfluorescent,and it can only light up through synergistic activation by H2S and in the tumor acidic environment(TEM).Such a“duallock-dual-key”strategy-based activatable probe exhibited significantly higher tumor-to-normal tissue(T/N)ratios than the“always on”agent(ICG)and single parameter responsive counterpart probes in the imaging of colon tumors,which overexpresses H2S.WH-N3 was also able to visualize the tumor-derived endogenous H2S fluctuation and accurately differentiate tumor types based on H2S content discrepancy.More excitingly,under the guidance of the probe’s highly specific NIR-II fluorescence,a tiny orthotopic colon tumor with diameter down to 0.8 mm was facilely resected.We expect our dual-stimuli responsive strategy will contribute more reliable tools for specific discrimination and imaging-guided excision of tumor.展开更多
With the presence of Coronavirus Disease 2019(COVID-19)asymptomatic infections detected,their proportion,transmission potential,and other aspects such as immunity and related emerging challenges have attracted people...With the presence of Coronavirus Disease 2019(COVID-19)asymptomatic infections detected,their proportion,transmission potential,and other aspects such as immunity and related emerging challenges have attracted people’s attention.We have found that based on highquality research,asymptomatic infections account for at least one-third of the total cases,whereas based on systematic review and meta-analysis,the proportion is about one-fifth.Evaluating the true transmission potential of asymptomatic cases is difficult but critical,since it may affect national policies in response to COVID-19.We have summarized the current evidence and found,compared with symptomatic cases,the transmission capacity of asymptomatic individuals is weaker,even though they have similar viral load and relatively short virus shedding duration.As the outbreak progresses,asymptomatic infections have also been found to develop long COVID-19.In addition,the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants continue to emerge.Nevertheless,as asymptomatic infections transmit the SARS-CoV-2 virus silently,they still pose a substantial threat to public health.Therefore,it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible;meanwhile,management of them is also a key point in the fight against COVID-19 community transmission.The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail.展开更多
In order to mitigate global warming,the international communities actively explore low-carbon and green development methods.According to the Paris Agreement that came into effect in 2016,there will be a global stockta...In order to mitigate global warming,the international communities actively explore low-carbon and green development methods.According to the Paris Agreement that came into effect in 2016,there will be a global stocktaking plan to carry out every 5 years from 2023 onwards.In September 2020,China proposed a"double carbon"target of carbon peaking before 2030 and carbon neutrality before 2060.Achieving carbon peaking and carbon neutrality goals requires accurate carbon emissions and carbon absorptions.China’s existing carbon monitoring methods have insufficient detection accuracy,low spatial resolution,and narrow swath,which are difficult to meet the monitoring requirement of carbon sources and sinks monitoring.In order to meet the needs of carbon stocktaking and support the monitoring and supervision of carbon sources and sinks,it is recommended to make full use of the foundation of the existing satellites,improve the detection technical specifications of carbon sources and sinks monitoring measures,and build a multi-means and comprehensive,LEO-GEO orbit carbon monitoring satellite system to achieve higher precision,higher resolution and multi-dimensional carbon monitoring.On this basis,it is recommended to strengthen international cooperation,improve data sharing policy,actively participate in the development of carbon retrieval algorithm and the setting of international carbon monitoring standards,establish an independent and controllable global carbon monitoring and evaluation system,and contribute China’s strength to the global realization of carbon peaking and carbon neutrality.展开更多
基金This work was supported by the National Natural Science Foundation of China(U1839203,42011540385)the National Key Laboratory of Earthquake Dynamics(LED2020B03,IGCEA1812)the Science and Technology Projects of Qinghai Province(2020-ZJ-752).
文摘The May 222021 M_(W)7.4 Madoi,Qinghai,China earthquake presented a rare opportunity to apply the modern unmanned aerial vehicle(UAV)photography method in extreme altitude and weather conditions to image surface ruptures and near-field effects of earthquake-related surface deformations in the remote Tibet.High-resolution aerial photographs were acquired in the days immediately following the mainshock.The complex surface rupture patterns associated with this event were covered comprehensively at 3-6 cm resolution.This effort represents the first time that an earthquake rupture in the interior of the Qinghai-Tibetan Plateau has been fully and systematically captured by such high-resolution imagery,with an unprecedented level of detail,over its entire length.The dataset has proven valuable in documenting subtle and transient rupture features,such as the significant mole-tracks and opening fissures,which were ubiquitous coseismically but degraded during the subsequent summer storm season.Such high-quality imagery also helps to document with high fidelity the fractures of the surface rupture zone(supplements of this paper),the pattern related to how the faults ruptured to the ground surface,and the distribution of off-fault damage.In combination with other ground-based mapping efforts,the data will be analyzed in the following months to better understand the mechanics of earthquake rupture related to the fault zone rheology,rupture dynamics,and frictional properties along with the fault interface.
基金This work was supported by National Natural Science Foundation of China(No.22068034)Science and Technology Innovation Talents Program of Bingtuan(No.2019CB025).
文摘Ni-Al mixed metal oxides have been successfully prepared by high shear mixer(HSM)and coprecipitation(CP)methods for low temperature CO methanation.In this work,Ni-Al(HSM-CP)catalyst presented small Ni crystallite size and high surface area,which all contribute to the methanation reaction at low temperature conditions.The obtained Ni-Al(HSM-CP)sample exhibited a mass of defective oxygen,thereby accelerating the dissociation of CO and ultimately increasing the activity of the catalyst.Ni-Al(HSM-CP)catalyst offered the best activity with CO conversion=100%and CH_(4) selectivity=93%at 300℃,and the CH_(4) selectivity can reach 81.8%at 200℃.In situ Fourier transform infrared spectroscopy and density functional theory show that CHO and COH intermediates with lower activation energy barriers are produced during the reaction,and hydrogen-assisted carbon–oxygen bond scission is more favorable.
基金supported by Shenzhen Fundamental Research Program(JCYJ20200109142425294).
文摘Infrared photovoltaic cells(IRPCs)have attracted considerable attention for potential applications in wireless optical power transfer(WOPT)systems.As an efcient fber-integrated WOPT system typically uses a 1550 nm laser beam,it is essential to tune the peak conversion efciency of IRPCs to this wavelength.However,IRPCs based on lead sulfde(PbS)colloidal quantum dots(CQDs)with an excitonic peak of 1550 nm exhibit low short circuit current(Jsc)due to insufcient absorption under monochromatic light illumination.Here,we propose comprehensive optical engineering to optimize the device structure of IRPCs based on PbS CQDs,for 1550 nm WOPT systems.The absorption by the device is enhanced by improving the transmittance of tin-doped indium oxide(ITO)in the infrared region and by utilizing the optical resonance efect in the device.Therefore,the optimized device exhibited a high short circuit current density of 37.65 mA/cm^(2)under 1 sun(AM 1.5G)solar illumination and 11.91 mA/cm^(2)under 1550 nm illumination 17.3 mW/cm^(2).Furthermore,the champion device achieved a record high power conversion efciency(PCE)of 7.17%under 1 sun illumination and 10.29%under 1550 nm illumination.The PbS CQDs IRPCs under 1550 nm illumination can even light up a liquid crystal display(LCD),demonstrating application prospects in the future.
文摘Hypertension,also known as high blood pressure,is a serious medical condition that may cause severe health problems,such as heart attack and stroke.According to the World Health Organization(WHO),^([1])an estimated 1.28 billion adults worldwide aged 30–79 years had hypertension in 2021,two-third of whom were living in low-and middle-income countries.Many national and international clinical practice guidelines(CPGs)on the diagnosis,evaluation,and treatment of hypertension have been published to promote its control.Among these,comprehensive hypertension guidelines provide broader direction to more target users,especially primary healthcare practitioners,than“narrow”types of guidelines.
基金financially supported by the National Natural Science Foundation of China(Nos.51577154,21373158 and21073139)the Key Laboratory of Engineering Dielectrics and Its Application,Ministry of Education,Harbin University of Science and Technology(No.KF20151111)+1 种基金the Natural Science Foundation of Shaanxi Province,China(No.2016JM5014)the fellowship provided by the China Scholarship Council(CSC)
文摘In this work, graphene oxide(GO) nanosheets with surface modification by Tannic and Fe coordination complexes(TA-Fe) were incorporated into poly(vinylidene fluoride)(PVDF) to prepare high constant but low loss polymer nanocomposites, and the effect of TA-Fe interlayer on dielectric properties of the GO@TA-Fe/PVDF nanocomposites was investigated. The results indicate that the dosage, mixing ratio, and reaction time of TA-Fe complexes have obvious influences on the dielectric properties of the nanocomposites. Furthermore, the TA-Fe interlayer significantly influences the electrical properties of GO@TA-Fe nanoparticles and their PVDF composites, and the GO@TA-Fe/PVDF composites exhibit superior dielectric properties compared with raw GO/PVDF. Dielectric losses of the GO@TA-Fe/PVDF are significantly suppressed to a rather low level owing to the presence of TA-Fe layer, which serves as an interlayer between the GO sheets, thus preventing them from direct contacting with each other. Additionally, the dynamic dielectric relaxation of the GO/PVDF and GO@TA-Fe/PVDF nanocomposites was investigated in terms of temperature.
文摘Background.Hundreds of coronavirus disease 2019(COVID-19)clinical practice guidelines(CPGs)and expert consensus statements have been developed and published since the outbreak of the epidemic.However,these CPGs are of widely variable quality.So,this review is aimed at systematically evaluating the methodological and reporting qualities of COVID-19 CPGs,exploring factors that may influence their quality,and analyzing the change of recommendations in CPGs with evidence published.Methods.We searched five electronic databases and five websites from 1 January to 31 December 2020 to retrieve all COVID-19 CPGs.The assessment of the methodological and reporting qualities of CPGs was performed using the AGREE II instrument and RIGHT checklist.Recommendations and evidence used to make recommendations in the CPGs regarding some treatments for COVID-19(remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir)were also systematically assessed.And the statistical inference was performed to identify factors associated with the quality of CPGs.Results.We included a total of 92 COVID-19 CPGs developed by 19 countries.Overall,the RIGHT checklist reporting rate of COVID-19 CPGs was 33.0%,and the AGREE II domain score was 30.4%.The overall methodological and reporting qualities of COVID-19 CPGs gradually improved during the year 2020.Factors associated with high methodological and reporting qualities included the evidence-based development process,management of conflicts of interest,and use of established rating systems to assess the quality of evidence and strength of recommendations.The recommendations of only seven(7.6%)CPGs were informed by a systematic review of evidence,and these seven CPGs have relatively high methodological and reporting qualities,in which six of them fully meet the Institute of Medicine(IOM)criteria of guidelines.Besides,a rapid advice CPG developed by the World Health Organization(WHO)of the seven CPGs got the highest overall scores in methodological(72.8%)and reporting qualities(83.8%).Many CPGs covered the same clinical questions(it refers to the clinical questions on the effectiveness of treatments of remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavirritonavir in COVID-19 patients)and were published by different countries or organizations.Although randomized controlled trials and systematic reviews on the effectiveness of treatments of remdesivir,glucocorticoids,hydroxychloroquine/chloroquine,interferon,and lopinavir-ritonavir for patients with COVID-19 have been published,the recommendations on those treatments still varied greatly across COVID-19 CPGs published in different countries or regions,which may suggest that the CPGs do not make sufficient use of the latest evidence.Conclusions.Both the methodological and reporting qualities of COVID-19 CPGs increased over time,but there is still room for further improvement.The lack of effective use of available evidence and management of conflicts of interest were the main reasons for the low quality of the CPGs.The use of formal rating systems for the quality of evidence and strength of recommendations may help to improve the quality of CPGs in the context of the COVID-19 pandemic.During the pandemic,we suggest developing a living guideline of which recommendations are supported by a systematic review for it can facilitate the timely translation of the latest research findings to clinical practice.We also suggest that CPG developers should register the guidelines in a registration platform at the beginning for it can reduce duplication development of guidelines on the same clinical question,increase the transparency of the development process,and promote cooperation among guideline developers all over the world.Since the International Practice Guideline Registry Platform has been created,developers could register guidelines prospectively and internationally on this platform.
基金National Science and Technology Major Project of China(2018ZX10713001-001).
文摘What is already known about this topic?Wulanchabu City Center for Endemic Disease Prevention and Control had established and used a Brucellosis Integrated Information System(BIIS)since 2013.However,it had not been systematically evaluated and promoted so far.What is added by this report?The BIIS had significantly improved the efficiency of brucellosis reporting and provided convenience for follow-up management of cases,which was valuable for finishing completely routine therapy.However,the stability of the system needs to be improved.What are the implications for public health practice?The results of the BIIS assessment demonstrated its advantages and disadvantages,which could provide some evidence for its implementation in other areas of China.
文摘In this study,we use eight pairs of commodity futures data to investigate the impact of the recently launched nighttime trading session by Chinese futures exchanges.We conduct a thorough empirical analysis on the cross-market information transmission mechanisms between China and the U.S.We apply various econometric analyses including the co-integration analysis,the forecast error variance decomposition analysis,and the volatility spillover analysis with a bivariate GARCH model.Findings in this study indicate that,after the launching of nighttime-trading hours in China,the price discovery function of the Chinese futures market is noticeably improved,and that the Chinese market began to dominate the U.S.market in the bidirectional volatility spillover process.Thus,the introduction of the nighttime-trading hours appears to be an effective step toward China’s long-term goal of establishing pricing power in key commodities on the global financial market.
基金This work was financially supported by the National Natural Science Foundation of China(grant no.21625503).The numerical calculations in this paper have been done on the supercomputing system in the Supercomputing Center of Wuhan University.
文摘Fluorescence imaging in the second infrared window(1000-1700 nm)has emerged as a promising approach to tumor diagnosis.However,the currently available second near-infrared(NIR-II)imaging agents are based on the“always on”modality or single biomarker activation,which are subject to limited imaging contrast,nonspecific response,and even false-positive diagnosis.Here,we developed a H2S/H+dual-stimuli responsive NIR-II fluorescent probe,WH-N3,for precise tumor delimitation and intraoperative fluorescence-guided surgical resection.WH-N3 itself is nonfluorescent,and it can only light up through synergistic activation by H2S and in the tumor acidic environment(TEM).Such a“duallock-dual-key”strategy-based activatable probe exhibited significantly higher tumor-to-normal tissue(T/N)ratios than the“always on”agent(ICG)and single parameter responsive counterpart probes in the imaging of colon tumors,which overexpresses H2S.WH-N3 was also able to visualize the tumor-derived endogenous H2S fluctuation and accurately differentiate tumor types based on H2S content discrepancy.More excitingly,under the guidance of the probe’s highly specific NIR-II fluorescence,a tiny orthotopic colon tumor with diameter down to 0.8 mm was facilely resected.We expect our dual-stimuli responsive strategy will contribute more reliable tools for specific discrimination and imaging-guided excision of tumor.
基金the National Natural Science Foundation of China(82041027)the China Medical Board(20-366)Peking University(PKU2020PKYZX002).
文摘With the presence of Coronavirus Disease 2019(COVID-19)asymptomatic infections detected,their proportion,transmission potential,and other aspects such as immunity and related emerging challenges have attracted people’s attention.We have found that based on highquality research,asymptomatic infections account for at least one-third of the total cases,whereas based on systematic review and meta-analysis,the proportion is about one-fifth.Evaluating the true transmission potential of asymptomatic cases is difficult but critical,since it may affect national policies in response to COVID-19.We have summarized the current evidence and found,compared with symptomatic cases,the transmission capacity of asymptomatic individuals is weaker,even though they have similar viral load and relatively short virus shedding duration.As the outbreak progresses,asymptomatic infections have also been found to develop long COVID-19.In addition,the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants continue to emerge.Nevertheless,as asymptomatic infections transmit the SARS-CoV-2 virus silently,they still pose a substantial threat to public health.Therefore,it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible;meanwhile,management of them is also a key point in the fight against COVID-19 community transmission.The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail.
文摘In order to mitigate global warming,the international communities actively explore low-carbon and green development methods.According to the Paris Agreement that came into effect in 2016,there will be a global stocktaking plan to carry out every 5 years from 2023 onwards.In September 2020,China proposed a"double carbon"target of carbon peaking before 2030 and carbon neutrality before 2060.Achieving carbon peaking and carbon neutrality goals requires accurate carbon emissions and carbon absorptions.China’s existing carbon monitoring methods have insufficient detection accuracy,low spatial resolution,and narrow swath,which are difficult to meet the monitoring requirement of carbon sources and sinks monitoring.In order to meet the needs of carbon stocktaking and support the monitoring and supervision of carbon sources and sinks,it is recommended to make full use of the foundation of the existing satellites,improve the detection technical specifications of carbon sources and sinks monitoring measures,and build a multi-means and comprehensive,LEO-GEO orbit carbon monitoring satellite system to achieve higher precision,higher resolution and multi-dimensional carbon monitoring.On this basis,it is recommended to strengthen international cooperation,improve data sharing policy,actively participate in the development of carbon retrieval algorithm and the setting of international carbon monitoring standards,establish an independent and controllable global carbon monitoring and evaluation system,and contribute China’s strength to the global realization of carbon peaking and carbon neutrality.