A nitric oxide-triggered hydrolysis reaction to construct controlled self-assemblies with complex topologies

Hydrolysis reactions are capable of directing the non-equilibrium assembly of biomolecular scaffolds to realize sophisticated structures and functions in natural systems.However,utilizing the proper hydrolysis reactions to construct controlled assemblies with complex topologies is still an arduous challenge in artificial systems and needs to be addressed.Herein,we report a nitric oxide(NO)-triggered slow hydrolysis strategy for the controlled construction of biomimetic supramolecular toroids(STs),thus realizing their visualization of intermediate structures and regulation of geometry parameters.This presented protocol harnesses hydrolysis reactions to control of non-equilibrium self-assembly processes for the construction of self-assemblies with complex topologies successfully,which sheds light on how the hydrolysis reaction rate can modulate the kinetic pathway of assembly,thus realizing the artificial establishment of bio-inspired hierarchical structures.

Health-related quality of life measurements in children and adolescents with refractive errors:A scoping review

Background:Refractive errors,particularly myopia,are the leading visual disorders worldwide,significantly affecting the quality of life(QOL)even after correction.This scoping review focuses on health-related quality of life(HRQOL)measurements for children and adolescents with refractive errors.Main text:We explored generic and disease-specific HRQOL tools,examining their content,psychometric prop-erties,and the impact of various interventions on QOL.Two English databases—PubMed,Embase,and one Chinese database,CNKI,were searched for relevant studies published from January 2001 to October 2023.In-clusion criteria encompassed studies using standardized instruments to assess the QOL of children aged 0–18 with refractive errors.The review compares prevalent HRQOL measurements,analyzes children's refractive error as-sessments,and discusses intervention effects on patient QOL.Conclusions:The study underlines the necessity of developing disease-specific QOL instruments for very young children and serves as a practical guide for researchers in this field.The findings advocate for a targeted approach in HRQOL assessment among the pediatric population,identifying critical gaps in current methodologies.