Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to colle...Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases.展开更多
Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spir...Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spirobased scaffolds have been extensively studied due to their unique advantages.In this work,we developed three emitters SPS,SPO,and SPON,which were constructed with the same donor and various acceptors to explore the influence of acceptor modulation at the C9 position of fluorene for spirostructure TSCT emitters.The results show that the acceptor with too weak electronwithdrawing ability will cause the emitter to not have TADF properties,while the acceptor with too much steric hindrance will weaken the face-to-faceπ-πstacking interaction between donor/acceptor(D/A).Since SPO balances the electron-withdrawing strength and steric hindrance of the acceptor,it achieves the highest external quantum efficiency(EQE)of 17.75%.This work shows that appropriate acceptor selection is essential for the TADF properties and high efficiency of the spirobased scaffold TSCT emitter.展开更多
基金supported by the National Key Research and Development Project(No.2021YFA1201400)National Natural Science Foundation of China(Nos.52073222,51573144 and 21474078)the Fundamental Research Funds for the Central Universities(WUT:2021IVA118 and 2022IVA201).
文摘Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases.
基金financial support from the National Natural Science Foundation of China(Nos.51773141,51873139,61961160731,62175171 and 22175124)funded by the Suzhou Science and Technology Plan Project(No.SYG202010)+2 种基金supported by Suzhou Key Laboratory of Functional Nano&Soft Materials,Collaborative Innovation Center of Suzhou Nano Science&Technologythe 111 ProjectJoint International Research Laboratory of Carbon-Based Functional Materials and Devices。
文摘Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spirobased scaffolds have been extensively studied due to their unique advantages.In this work,we developed three emitters SPS,SPO,and SPON,which were constructed with the same donor and various acceptors to explore the influence of acceptor modulation at the C9 position of fluorene for spirostructure TSCT emitters.The results show that the acceptor with too weak electronwithdrawing ability will cause the emitter to not have TADF properties,while the acceptor with too much steric hindrance will weaken the face-to-faceπ-πstacking interaction between donor/acceptor(D/A).Since SPO balances the electron-withdrawing strength and steric hindrance of the acceptor,it achieves the highest external quantum efficiency(EQE)of 17.75%.This work shows that appropriate acceptor selection is essential for the TADF properties and high efficiency of the spirobased scaffold TSCT emitter.
