Hot deformation behavior of FGH96 superalloys

The hot deformation behavior of FGH96 superalloys at 1070-1170℃ and 5×10^-4-2×10^-1 s^-1 were investigated by means of the isothermal compression tests at a Gleeble-1500 thermal mechanical simulator. The results show that dynamic recovery acts as the main softening mechanism below 2×10^-3 s^-1, whereas dynamic recrystallization acts as the main softening mechanism above 2× 10^-3 s^-1 during deformation; the temperature increase caused by the deformation and the corresponding softening stress is negligible; the thermal-mechanical constitutive model to describe the hot deformation behavior is given, and the value of the apparent deformation activation energy （Qdef） is determined to be 354.93 kJ/mol.

High-resolution spatiotemporal mapping:a comprehensive view of eukaryotic cell cycle proteome dynamics

In a recent study published in Cell,Litsios et al.revealed a highresolution spatiotemporal map of the eukaryotic cell cycle proteome.1 They identified proteome-level changes in both abundance and spatial distribution throughout the cell cycle and provided a valuable resource for future exploration into the global proteome dynamics that drive cell cycle progression(https://thecellvision.org/cellcycle).

Liquid-liquid phase separation in human health and diseases

Emerging evidence suggests that liquid-liquid phase separation(LLPS)represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells(also known as biomolecular condensates or droplets).Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases.In this review,we describe our current understanding of LLPS and summarize its physiological functions.We further describe the role of LLPS in the development of human diseases.Additionally,we review the recently developed methods for studying LLPS.Although LLPS research is in its infancy-but is fast-growing-it is clear that LLPS plays an essential role in the development of pathophysiological conditions.This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.

Alterations in microbiota of patients with COVID-19:potential mechanisms and therapeutic interventions

The global coronavirus disease 2019(COVID-19)pandemic is currently ongoing.It is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).A high proportion of COVID-19 patients exhibit gastrointestinal manifestations such as diarrhea,nausea,or vomiting.Moreover,the respiratory and gastrointestinal tracts are the primary habitats of human microbiota and targets for SARS-CoV-2 infection as they express angiotensin-converting enzyme-2(ACE2)and transmembrane protease serine 2(TMPRSS2)at high levels.There is accumulating evidence that the microbiota are significantly altered in patients with COVID-19 and post-acute COVID-19 syndrome(PACS).

Novel pyroptosis-independent functions of gasdermins

Recently,Rana et al.and Zhang et al.published two studies illustrating the important regulatory roles of gasdermin B(GSDMB)and-D(GSDMD)in inflammatory bowel disease(IBD)and intestinal immune homeostasis maintenance,respectively.1,2 Their findings collectively indicate that the gasdermins(GSDMs)can play a crucial role in restoring epithelial barrier function and shaping gut mucosal homeostasis.Moreover,neither of the functions of GSDMs revealed by these two studies are related to pyroptosis,which may provide new insights into the non-pyroptosis-dependent functions of GSDM proteins.