Covalency competition induced selective bond breakage and surface reconstruction in manganese cobaltite towards enhanced electrochemical charge storage

Manganese cobaltite(MnCo_(2)_(4))is a promising electrode material because of its attractive redox chemistry and excellent charge storage capability.Our previous work demonstrated that the octahedrally-coordinated Mn are prone to react with the hydroxyl ions in alkaline electrolyte upon electrochemical cycling and separates on the surface of spinel to reconstruct into d-MnO_(2) nanosheets irreversibly,thus results in a change of the reaction mechanism with Kþion intercalation.However,the low capacity has greatly limited its practical application.Herein,we found that the tetrahedrally-coordinated Co_(2) þions were leached when MnCo_(2)_(4) was equilibrated in 1 mol L^(-1) HCl solution,leading to the formation of layered CoOOH on MnCo_(2)_(4) surface which is originated from the covalency competition induced selective breakage of the CoT–O bond in CoT–O–CoO and subsequent rearrangement of free Co_(6) octahedra.The as-formed CoOOH is stable upon cycling in alkaline electrolyte,exhibits conversion reaction mechanism with facile proton diffusion and is free of massive structural evolution,thus enables utilization of the bulk electrode material and realizes enhanced specific capacity as well as facilitated charge transfer and ion diffusion.In general,our work not only offers a feasible approach to deliberate modification of MnCo_(2)_(4)'s surface structure,but also provides an in-depth understanding of its charge storage mechanism,which enables rational design of the spinel oxides with promising charge storage properties.

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis

Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression.

Light-triggered interfacial charge transfer and enhanced photodetection in CdSe/ZnS quantum dots/MoS_(2)mixed-dimensional phototransistors

Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer is of vital import-ance for guiding the design of functional optoelectronic applications.In this work,type-Ⅱ0D-2D CdSe/ZnS quantum dots/MoS_(2)vdWHs are designed to study the light-triggered interfacial charge behaviors and enhanced optoelectronic performances.From spectral measurements in both steady and transient states,the phenomena of suppressed photolu-minescence(PL)emissions,shifted Raman signals and changed PL lifetimes provide strong evidences of efficient charge transfer at the 0D-2D interface.A series of spectral evolutions of heterostructures with various QDs overlapping concentrations at different laser powers are analyzed in details,which clarifies the dynamic competition between exciton and trion during an efficient doping of 3.9×10^(13)cm^(−2).The enhanced photoresponses(1.57×10^(4)A·W^(-1))and detectivities(2.86×10^(11)Jones)in 0D/2D phototransistors further demonstrate that the light-induced charge transfer is still a feasible way to optimize the performance of optoelectronic devices.These results are expected to inspire the basic understand-ing of interfacial physics at 0D/2D interfaces,and shed the light on promoting the development of mixed-dimensional op-toelectronic devices in the near future.

Advances of Genetic Testing Technology in Etiology Diagnosis of Recurrent Spontaneous Abortion

Recurrent spontaneous abortion (RSA) is a complex and heterogeneous disorder with multiple etiologies. Genetic factors are thought to play an important role in the etiology of RSA. With recent advances in genetic testing technologies, there has been an increasing interest in using these tools to diagnose the etiology of RSA. This review discusses the different types of genetic testing methods, such as karyotyping, chromosomal microarray analysis, next-generation sequencing, and their applications in the diagnosis of the etiology RSA. The use of genetic testing in the diagnosis of RSA has the potential to improve the accuracy of diagnosis and the understanding of the underlying mechanisms of the disorder, which could lead to better management and treatment of affected individuals.

Cobalt coordination with pyridines in sulfurized polyacrylonitrile cathodes to form conductive pathways and catalytic M-N4S sites for accelerated Li-S kinetics

Sulfurized polyacrylonitrile(SPAN)represents a unique class of cathode material for lithium sulfur(Li-S)batteries as it eradicates the polysulfides shuttling issue in carbonate-based electrolyte.However,due to the essential chemical S-linking and organic nature of SPAN,the active mass percentage and rate capability are two bottleneck issues preventing its ultimate deployment outside of laboratories.In the current work,aiming to endow both the charge conductivity and catalytic activity to SPAN for maximizing the redox kinetics of S conversion,a freestanding nanofibrous SPAN cathode embedding conductive CNTs and atomically dispersed Co centers is fabricated via multivariate electrospinning.While the CNTs enable dramatically enhancing the fiber conductivity and generating mesoscopic porosity for facilitating charge and mass transportation,the cross-linking of SPAN by Co-N_(4) S motifs creates extra charge conduction pathways and further serves as the catalytic active sites for expediting redox S conversion.As a result,an extraordinary Li-SPAN performance is achieved with a high specific capacity up to 1856 mAh g^(-1)@0.2 C,a superb rate capability up to 10 C,and an ultra-long battery life up to 1500 cycles@1 C.Consequently,our study here provides insights into the adoption of coordination chemistry to maximize the sulfur utilization by ensuring a more complete redox conversion from SPAN to Li2 S,and vice versa.

The Effect of Organ Temperature on Total Yield of Transplanted and Direct-Seeded Rice(Oryza sativa L.)

The canopy temperature of rice is an important index that directly reflects the growth and physiological state of rice,and affects the yield of rice plants to a great extent.The correlation between the temperatures of different rice organs and canopy in different growth stages and the grain yield is complex.The stability and universality of these correlations must be verified.We conducted a pot experiment using two rice varieties and two temperature treatments(high temperature treatment was carried out at the beginning of heading stage for 10 days).We measured rice organ temperature during seven stages of growth using a high-precision infrared thermal imager.Results showed that the optimal observation period for the rice canopy temperature was 13:00.Although the rice variety did not significantly impact the canopy or organ temperature(p>0.05),the different organs and canopy exhibited significantly different temperatures(p<0.05).The correlations between the leaf,stem,panicle,canopy–air temperature differences and seed setting rate,theoretical and actual yields were the strongest during the milk stage.Among them,the correlation coefficient betweenΔT_(s) and theoretical and actual yields was the highest,the relationship between theoretical yield(Y)andΔT_(s)(X)was Y=−5.6965X+27.778,R^(2)=0.9155.Compared withΔT_(l),ΔT_(p) andΔTc,ΔT_(s) was closely related to the main traits of plants.ΔT_(s) could better reflect the growth characteristics of rice thanΔT_(c),such as dry matter accumulation(r=−0.931),SPAD(r=0.699),N concentration(r=0.714),transpiration rate(r=−0.722).In conclusion,stem temperature was more important indicator than canopy temperature.Stem temperature is a better screening index for rice breeding and cultivation management in the future.

Lens-free wavefront shaping method for a diffuse non-lineof-sight link in visible light communication

In this Letter,we propose and experimentally demonstrate a lens-free wavefront shaping method that utilizes synchronized signal block beam alignment and a genetic algorithm(SSBGA)for a diffuse non-line-of-sight(NLOS)visible light communication(VLC)system.The proposed method effectively controls the position and mobility of visible light beams by partitioning spatial light modulator pixels and manipulating beams to converge at distinct spatial positions,thereby enhancing wavefront shaping efficiency,which achieves a significant 23.9 dB optical power enhancement at+2 mm offset,surpassing the lens-based continuous sequence(CS)scheme by 21.7 dB.At+40°angle,the improvement reaches up to 11.8 dB and 16.8 dB compared to the results with and without lens-based CS,respectively.A maximum rate of 5.16 Gbps is successfully achieved using bit-power loading discrete multi-tone(DMT)modulation and the proposed SSBGA in an NLOS VLC system,which outperforms the lens-based CS by 1.07 Gbps and obtains a power saving of 55.6%during the transmission at4 Gbps.To the best of our knowledge,this is the first time that high-speed communication has been realized in an NLOS VLC system without a lens.

The Role of Endoplasmic Reticulum Stress Sensor Protein CREB3L2 in the Development of Tissues and Tumors

The endoplasmic reticulum plays an extremely important role in the process of cellular protein secretion.The cyclic AMP-responsive element-binding protein 3(CREB3)transcription factor family is closely associated with the secretion and transport of proteins within the endoplasmic reticulum.As a member of the CREB3 transcription factor family,cyclic AMP-responsive element-binding protein 3-like protein 2(CREB3L2)stands out as a non-classical sensor within the endoplasmic reticulum.CREB3L2 can detect and regulate endoplasmic reticulum pressure,exert control over the processes of protein transport and secretion,participate in the development of tumor cells,and is also closely linked to the development of certain human tissues and organs.This article aims to review the role of CREB3L2 in tissue development and disease,shedding light on the related mechanisms of CREB3L2 in cancer development.The goal is to provide insights and directions for further analysis of CREB3L2.

国内学术界政治价值观的研究:回顾、反思与展望

20世纪90年代以来,政治价值观一直是国内学术界关于政治文化研究的重点内容之一,并且在研究内容、研究方法与研究范式等方面取得了丰硕的成果。与此同时,政治价值观研究依旧面临着诸多的困境和挑战:政治学视角的研究相对匮乏;核心概念的界定模糊,测量指标体系混杂;实证调查设计和数据分析缺陷明显;西方中心主义突出,中国本位与中国问题意识不足。因此,要增强政治价值观研究的学科话语意识,在反思与批判的基础之上,拓展国内学术界关于政治价值观研究的话语空间,建构科学化的政治价值观测量指标体系,提升政治价值观实证研究的科学性与针对性。

Exosomes in cancer immunoediting and immunotherapy

As an important means of communication among cells,exosomes are being studied more and more widely,especially in the context of cancer immunotherapy.In the phase of tumor immunoediting,exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions,because they carry different proteins and nucleic acid from the source cells.Based on the role of exosomes in the communication between different cells,cancer treatment methods are also under continuous research.This review briefly introduces the molecular composition of exosomes,which is closely related to their secretion mechanism.Subsequently,the role of exosomes encapsulating different information molecules is summarized.The role of exosomes in the three phases of tumor immunoediting is introduced in detail,and the relevant literature of exosomes in the tumor immunemicroenvironment is summarized by using a novel framework for extracting relevant documents.Finally,it summarizes the various exosome-based immunotherapies currently proposed,as well as the challenges and future prospects of exosomes in tumor immunotherapy.

Optimization of Spray Drying Processing Technology of Mulberry Powder

With concentrated juice of mulberry as raw material, the influence of type and dosage of dry aid, the inlet air temperature, inlet flow rate, and rotating speed on spray drying was studied. The spray drying processing conditions of mulberry powder were optimized by the L9(34) orthogonal test on the basis of single factor experiment. The results showed that optimum technical parameters to produce mulberry powder were: β-cyclodextrin as dry aids with dosage of 30%, inlet air temperature of180 ℃, rotating speed of 18 000 r/min and inlet flow rate of 30 m L/min. The mulberry powder under this optimum process conditions had a loose structure and bright color, fruity flavor was rich, the anthocyanin content for 54.67 mg/g, moisture content for5.6% and sensory scores for 83.

Rapid bioluminescence assay for monitoring rat CES1 activity and its alteration by traditional Chinese medicines

In traditional Chinese medicine herbs(TCM),including Radix Salviae Miltiorrhizae(Danshen),Radix Puerariae Lobatae(Gegen),Radix Angelicae Sinensis(Danggui),and Rhizoma Chuanxiong(Chuanxiong)are widely used for the prevention and treatment of cardiovascular diseases and also often co-administered with Western drugs as a part of integrative medicine practice.Carboxylesterase 1(CES1)plays a pivotal role in the metabolisms of pro-drugs,Since(S)-2-(2-(6-dimethylamino)-benzothiazole)-4,5-dihydrothiazole-4-carboxylate(NLMe)has recently been identified by us as a selective CES1 bioluminescent sensor,we developed a rapid method using this substrate for the direct measurement of CES1 activity in rats.This bioluminescence assay was applied to determine CES1 activity in rat tissues after a two-week oral administration of each of the four herbs noted above.The results demonstrated the presence of CES1 enzyme in rat blood and all tested tissues with much higher enzyme activity in the blood,liver,kidney and heart than that in the small intestine,spleen,lung,pancreas,brain and stomach.In addition,the four herbs showed tissue-specific effects on rat CES1 expression.Based on the CES1 biodistribution and its changes after treatment in rats,the possibility that Danshen,Gegen and Danggui might alter CES1 activities in human blood and kidney should be considered.In summary,a selective and sensitive bioluminescence assay was developed to rapidly evaluate CES1 activity and the effects of orally administered TCMs in rats.

Recent Development of Quantum Dot Deposition in Quantum Dot-Sensitized Solar Cells

As new-generation solar cells,quantum dot-sensitized solar cells(QDSCs)have the outstanding advantages of low cost and high theoretical efficiency;thus,such cells receive extensive research attention.Their power conversion efficiency(PCE)has increased from 5%to over 15%in the past decade.However,compared with the theoretical efficiency(44%),the PCE of QDSCs still needs further improvement.The low loading amount of quantum dots(QDs)is a key factor limiting the improvement of cell efficiency.The loading amount of QDs on the surface of the substrate film is important for the performance of QDSCs,which directly affects the light-harvesting ability of the device and interfacial charge recombination.The optimization of QD deposition and the improvement of the loading amount are important driving forces for the rapid development of QDSCs in recent years and a key breakthrough in future development.In this paper,the research progress of QD deposition on the surface of substrate films in QDSCs was reviewed.In addition,the main deposition methods and their advantages and disadvantages were discussed,and future research on the further increase in loading amount was proposed.

Double-stretching as an effective and generalizable strategy towards thinner nanofibers in solution blow spinning

Solution blow spinning(SBS)applies high-speed airflow to prepare fibers by generating a strong stretching force.It has the advantages of scalable production,tailorable morphologies,and wide applicability.Yet,the SBS strategy can hardly prepare fibers down to the sub-100 nanometers,which limits its performance in demanding applications.Herein,we overcome the limitation of SBS by introducing a second airflow.This novel strategy is termed double-stretching SBS(DS-SBS)because an extra stretching force is exerted on the fiber when it converges with the second airflow.Polyamide6 nanofibers with an average diameter of 80 nm are successfully prepared with the DS-SBS strategy,while the SBS strategy could only prepare submicron fibers with an average diameter of 120 nm.Further,the generality of the DS-SBS strategy to reduce fiber diameter is verified on numerous solute-solvent pairs.

Si-substrate vertical-structure InGaN/GaN micro-LED-based photodetector for beyond 10 Gbps visible light communication

Visible light communication(VLC)has emerged as a promising communication method in 6G.However,the development of receiving devices is much slower than that of transmitting devices,limited by materials,structures,and fabrication.In this paper,we propose and fabricate an InGaN/GaN multiple-quantum-well-based vertical-structure micro-LED-based photodetector(μPD)on a Si substrate.A comprehensive comparison of the photoelectrical performance and communication performance of three sizes ofμPDs,10,50,and 100μm,is presented.The peak responsivity of all threeμPDs is achieved at 400 nm,while the passband full-widths at half maxima are 87,72,and 78 nm for 10,50,and 100μmμPDs,respectively.The−20 dB cutoff bandwidth is up to 822 MHz for 50μmμPD.A data rate of 10.14 Gbps is experimentally demonstrated by bit and power loading discrete multitone modulation and the proposed digital pre-equalizer algorithm over 1 m free space utilizing the self-designed 4×450μmμPD array as a receiver and a 450 nm laser diode as a transmitter.This is the first time a more than 10 Gbps VLC system has been achieved utilizing a GaN-based micro-PD,to the best of our knowledge.The investigation fully demonstrates the superiority of Si substrates and vertical structures in InGaN/GaNμPDs and shows its great potential for high-speed VLC links beyond 10 Gbps.

Plasmonically engineered light-matter interactions in Aunanoparticle/MoS_(2) heterostructures for artificial optoelectronic synapse

Optoelectronic synaptic elements are emerging functional devices for the vigorous development of advanced neuromorphic computing technology in the post-Moore era.However,optoelectronic devices based on transition metal dichalcogenides(TMDs)are limited to their poor mobilities and weak light-matter interactions,which still hardly exhibit superior device performances in the application of artificial synapses.Here,we demonstrate the successful fabrication of Au nanoparticle-coupled MoS_(2)heterostructures via chemical vapor deposition(CVD),where the light absorption of MoS_(2)is greatly enhanced and engineered by plasmonic effects.Hot electrons are excited from Au nanoparticles,and then injected into MoS_(2)semiconductors under the light illumination.The plasmonically-engineered photo-gating effect at the metal-semiconductor junction is demonstrated to create optoelectronic devices with excellent synaptic behaviors,especially in ultra-sensitive excitatory postsynaptic current(EPSC,9.6×10^(-3)nA@3.4 nW·cm^(-2)),ultralow energy consumption(34.7 pJ),long-state retention time(>1,000 s),and tunable synaptic plasticity transitions.The material system of Au-nanoparticles coupled TMDs presents unique advantages for building artificial synapses,which may lead the future development of neuromorphic electronics in optical information sensing and learning.

Merging daily sea surface temperature data from multiple satellites using a Bayesian maximum entropy method

海表面温度(SST ) 是为理解在海洋和空气之间的相互作用的一个重要变量。SST 熔化为获得高空间的分辨率和范围的 SST 产品是关键的。这研究介绍贝叶斯的最大的熵(BME ) 为从多重卫星传感器混合每日的 SST 的方法。一块 SST 地的一个新空间与时间的协变性模型被造集成不仅单个天的 SST 而且时间邻近的 SST。另外， AVHRR 30 年的 SST 气候学数据在评价点作为软数据被介绍在 BME 框架以内改进混合结果的精确性。与 4 km 的空间分辨率和 24 个小时的时间的分辨率，合并 SST 在西方的太平洋区域被生产表明并且评估建议方法论。比较与在合并 SST 是精确的 situ 漂流浮标观察表演和偏爱和 root-mean-square，为比较的错误是 0.

An efficient method of evaluating large scale urban residential skylight environment and an empirical study of Beijing main area

A good skylight environment in urban residential areas is an important component of a healthy city,and has always been highly valued.With the rapid development of new-type urbanization,the density of buildings continues to increase,and megacities have entered the stage of stock transformation.An effective method for evaluating the skylight environment of large-scale urban residential areas is urgently needed.However,there is still a lack of empirical research methods and cases of large-scale residential skylight environment.In this regard,this article takes the megacity Beijing as the research object,and proposes an efficient analysis method of residential skylight environment that integrates multiple real-world data at city scale.In terms of data,it collects and integrates 3D data of urban-scale building space and residential boundary data;in terms of algorithm,Sky View Factor(SVF)is used as the evaluation index of residential skylight environment,and an efficient analysis method of urban-scale skylight environment based on cloud parallel simulation is realized.Through analysis,it is found that:(1)the average SVF value of Beijing residential area is 61%,which means that its skylight quality is in general level;(2)the skylight environment of Beijing residential area is distributed in a circle,and there are 4 types of skylight environment quality residential areas;(3)The skylight environment of Beijing residential area is relatively weakly related to the distance from the residential area to the city center and the average height of the residential buildings,and is closely related to the plot volume ratio,the residential building density and the shading from surrounding buildings.The highlight of this study lies in the empirical research on the skylight environment of mega-city residential areas that incorporates multiple real data for the first time,which can promote the study of skylight environment on a city scale and provide a reference for the updating of Beijing’s residential daylight environment.

Silver-catalyzed stereoselective C-4 arylthiodifluoromethylation of coumarin-3-carboxylic acids via a double decarboxylative strategy

A facile silver-catalyzed dual decarboxylation of arylthio-difluoroacetic acid with coumarin-3-carboxylic acids/chromone-3-carboxylic acids was developed.This method provided a unique way to synthesize a series of C-4 arylthiodifluoromethylated 3,4-dihydrcoumarins/C-2 arylthiodifluoro-methylated chromanone derivatives in moderate to good yields under mild conditions.

An ultralight,flexible,and biocompatible all-fiber motion sensor for artificial intelligence wearable electronics

New-generation human body motion sensors for wearable electronics and intelligent medicine are required to comply with stringent requirements in terms of ultralight weight,flexibility,stability,biocompatibility,and extreme precision.However,conventional sensors are hard to fulfill all these criteria due to their rigid structure,high-density sensing materials used as the constituents,as well as hermetical and compact assembly strategy.Here,we report an ultralight sensing material based on radial anisotropic porous silver fiber(RAPSF),which has been manufactured by phase separation and temperature-controlled grain growth strategy on a modified blow-spinning system.The resistance of RAPSF could be dynamically adjusted depending on the deflected shape.Furthermore,an all-fiber motion sensor(AFMS)with an ultra-low density of 68.70 mg cm^(−3) and an overall weigh of 7.95 mg was fabricated via layer-by-layer assembly.The sensor exhibited outstanding flexibility,breathability,biocompatibility,and remarkable body motion recognition ability.Moreover,the AFMS was shown to have great potential as an artificial intelligence throat sensor for throat state identification at the accuracy above 85%,allowing one to spot the early onset of the viral throat illness.