Analysis of the Effects of Preoperative Hepatic Artery Chemoembolization and Quality Nursing Intervention on the Perioperative Safety and Short-term Prognosis of Liver Transplantation in Patients with Hepatocellular Carcinoma

Objective: To investigate the effects of preoperative hepatic artery chemoembolization (TACE) and quality nursing interventions on the perioperative safety and short-term prognosis in patients with hepatocellular carcinoma undergoing liver transplantation. Methods: The study period spanned from January 2021 to December 2023, and 125 patients with hepatocellular carcinoma admitted to our hospital were selected, all of whom underwent liver transplantation. They were randomly divided into an observation group (n = 63) and a control group (n = 62). The patients in the control group did not undergo TACE before the operation, and the patients in the observation group underwent TACE and quality nursing intervention before the operation. The operation time, intraoperative blood loss, length of hospitalization, liver- free period, complication rate, short-term prognosis, and liver function indexes between the two groups were compared. Results: There was no significant difference in operation time, intraoperative blood loss, and length of hospitalization between the two groups (P < 0.05). The liver-free period of patients in the observation group was longer than that of the control group (P < 0.05). The two groups had no significant difference in the incidence of biliary complications, vascular complications, and postoperative infections (P > 0.05). The rate of immune reactive complications in the observation group was lower than that of the control group (P < 0.05). There was no significant difference in the perioperative mortality rate, 1-year postoperative survival rate, and 2-year postoperative survival rate (P > 0.05). The two groups had no significant difference in postoperative liver function indexes (P > 0.05). Conclusion: Preoperative TACE and high-quality nursing intervention in patients with hepatocellular carcinoma had no adverse effect on the perioperative safety and short-term prognosis, prolonged the liver-free time, and reduced the incidence of immune-reactive complications.

An improved transfer learning strategy for short-term cross-building energy prediction usingdata incremental

The available modelling data shortage issue makes it difficult to guarantee the performance of data-driven building energy prediction(BEP)models for both the newly built buildings and existing information-poor buildings.Both knowledge transfer learning(KTL)and data incremental learning(DIL)can address the data shortage issue of such buildings.For new building scenarios with continuous data accumulation,the performance of BEP models has not been fully investigated considering the data accumulation dynamics.DIL,which can learn dynamic features from accumulated data adapting to the developing trend of new building time-series data and extend BEP model's knowledge,has been rarely studied.Previous studies have shown that the performance of KTL models trained with fixed data can be further improved in scenarios with dynamically changing data.Hence,this study proposes an improved transfer learning cross-BEP strategy continuously updated using the coarse data incremental(CDI)manner.The hybrid KTL-DIL strategy(LSTM-DANN-CDI)uses domain adversarial neural network(DANN)for KLT and long short-term memory(LSTM)as the Baseline BEP model.Performance evaluation is conducted to systematically qualify the effectiveness and applicability of KTL and improved KTL-DIL.Real-world data from six-type 36 buildings of six types are adopted to evaluate the performance of KTL and KTL-DIL in data-driven BEP tasks considering factors like the model increment time interval,the available target and source building data volumes.Compared with LSTM,results indicate that KTL(LSTM-DANN)and the proposed KTL-DIL(LSTM-DANN-CDI)can significantly improve the BEP performance for new buildings with limited data.Compared with the pure KTL strategy LSTM-DANN,the improved KTL-DIL strategy LSTM-DANN-CDI has better prediction performance with an average performance improvement ratio of 60%.

A review on the sealing structure and materials of fuel-cell stacks

Proton-exchange-membrane fuel cells(PEMFCs)have the characteristics of zero emissions,a low operating temperature and high power density,and have great potential in improving energy-utilization efficiency.However,fuel cells are still quite expensive as a result of the cost of key components,including the membranes,catalysts and bipolar plates of PEMFCs.As a result of the cost and importance of these items,most researchers have focused on improving the lifetime and performance of fuel-cell stacks in recent years.In contrast,seals,sealants and adhesives play a more mundane role in the overall performance of a fuel cell,but failure of these materials can lead to reduced system efficiency,system failure and even safety issues.Little attention has been paid to the performance and durability of these products but as other fuel-cell components improve,these seals are becoming an even more critical link in the long-term performance of fuel cells.This article highlights the importance and background of fuel-cell seals.The latest research progress on the mechanical properties and structural optimization of different sealing materials is reviewed.

Piglet growth performance improved by dietary supplementation of porous or nano particles of zinc oxide may be related to the gut microbiota

Previous studies on porous or nano particles zinc oxide(ZnO)in the piglets have mainly focused on growth performance and intestinal inflammation,but have scarcely explored the efficacy on gut microbiota.In addition,the efficacy of nano particles ZnO,which is related to its product quality,remains undefined.This study aimed to determine the efficacy of dietary 500 mg/kg porous or nano particles ZnO on the growth performance and gut microbiota of the weaned piglets.A total of 128 weaned piglets were randomly assigned to the dietary groups:NC(basal diet),PC(basal diet+3,000 mg/kg conventional ZnO),500HiZ(basal diet+500 mg/kg porous particles ZnO),and 500ZNP(basal diet+500 mg/kg nano particles ZnO).Compared with the NC diet group,both 500HiZ and 500ZNP increased(P<0.05)average daily feed intake(1 to 28 d)and average daily gain(1 to 28 d),and the 500ZNP tended to decrease feed to gain ratio(F:G ratio,1 to 28 d)(P=0.09).Both 500HiZ and 500ZNP decreased crypt depth of the ileum and increased claudin-2 in the duodenum and zonula occludens-1 in the ileum(P<0.05).Moreover,both 500HiZ and 500ZNP decreased IL-1βand tumor necrosis factor-a(TNF-a)in the jejunum and decreased TNF-a and IL-6 in the ileum(P<0.05).Both 500HiZ and 500ZNP increased microbialβ-diversity index in the ileum and microbial a-diversity indices in the colon of piglets(P<0.05).The probiotic genera Coprococcus(500ZNP)and Blautia(500HiZ)were positively correlated with the F:G ratio(1to 28 d)in colon of piglets(P<0.05).In addition,500HiZ promoted mitochondrial fusion protein 1(MFN1)and zinc transporter-1(ZnT-1)in the jejunum(P<0.05),whilst 500ZNP decreased MFN1 in the jejunum and ZnT-1 in the ileum(P<0.05).In summary,both 500HiZ and 500ZNP improved the growth performance of piglets,which is likely via the genera Blautia and Coprococcus,respectively.Both 500HiZ and 500ZNP improved barrier function and inflammation of the intestine,and 500HiZ achieved better efficacy than 500ZNP on intestine mitochondrial functions.

Diagnostic accuracy and safety of Dermatophagoides pteronyssinus extracts used for skin prick test

Background:Dermatophagoides pteronyssinus is a common allergen causing allergic diseases in China.The aim of this study was to evaluate the efficacy and safety of D.pteronyssinus extracts produced by Peking Union Medical College Hospital(PUMCH)for the skin prick test(SPT)in the diagnosis of D.pteronyssinus allergy.Methods:A total of 910 subjects with allergic diseases were prescribed D.pteronyssinus SPT and specific sIgE(sIgE)test among the Outpatients of Department of Allergy,PUMCH from August 10,2015 to August 30,2017.Receiver operating characteristic curve(ROC)analysis was performed according to the results of D.pteronyssinus-sIgE detection.The accuracy of D.pteronyssinus extracts used for SPT in the diagnosis of D.pteronyssinus allergy was evaluated under different cutoff values.Adverse events after SPT were recorded to evaluate safety.Results:There were 796 and 618 subjects in the full analysis set(FAS)and the per protocol set(PPS),respectively.The areas under the curve of FAS and PPS were 0.871 and 0.873,respectively.According to the ROC of PPS,the optimal and 95%specificity diagnostic cutoff values of D.pteronyssinus SPT mean wheal diameter were 3.25 and 3.75 mm,respectively.No adverse events occurred.Conclusion:The extracts of D.pteronyssinus for SPT were simple,highly accurate,and safe and should be considered for recommendation in the clinical diagnosis of D.pteronyssinus allergy.

An intercomparison of ozone taken from the Copernicus atmosphere monitoring service and the second Modern-Era retrospective analysis for research and applications over China during 2018 and 2019

Spatiotemporal variations of ozone(O_(3))taken from the Copernicus Atmosphere Monitoring Service(CAMS)and the second Modern-Era Retrospective Analysis for Research and Applications(MERRA-2)were intercompared and evaluated with ground and ozone-sonde observations over China in 2018 and 2019.Intercomparison of the surface ozone from CAMS and MERRA-2 reanalysis showed significant negative bias(CAMS minus MERRA-2,same below)at Tibetan Plateau of up to 80μg/m^(3),and the average R^(2)was about 0.6 across China.Evaluated with the ground observations from China National Environmental Monitoring Center(CNEMC),we found that CAMS and MERRA-2 reanalysis were capable of capturing the key patterns of monthly and diurnal variations of surface ozone over China except for the western region,and MERRA-2 overestimated the observations compared to CAMS.Vertically,the CAMS profiles overestimated the ozone-sonde from the World Ozone and Ultraviolet Radiation Data Center(WOUDC)above 200 h Pa with the magnitude reaching up to 150μg/m3,while little bias was found between the reanalysis and observations below 200 h Pa.Intercomparison drawn from the vertical distribution between CAMS and MERRA-2 reanalysis showed that the negative bias appeared throughout the troposphere over China,while the positive bias emerged in the upper troposphere and lower stratosphere(UTLS)with high order of magnitude exceeding 100μg/m^(3),indicating large uncertainties at higher altitudes.In summary,we concluded that CAMS reanalysis showed better agreement with the observations in contrast to MERRA-2,and the large discrepancy especially at higher altitudes between these two reanalysis datasets could not be ignored.

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not satisfactory.Nanomaterial-mediated therapy targeting SSTR2 in NETs is very promising.This study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared light.AuNRs@mSiO_(2)@DOTA-TATE showed good photothermal conversion efficiency.In vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with light.In vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other groups.There was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other groups.No significant inflammatory lesions or cell necrosis was found in the main organs.In summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.