A combined magnetic field stabilization system for improving the stability of 40Ca^(+) optical clock

Future applications of portable40Ca^(+)optical clocks require reliable magnetic field stabilization to improve frequency stability, which can be achieved by implementing an active and passive magnetic field noise suppression system. On the one hand, we have optimized the magnetic shielding performance of the portable optical clock by reducing its apertures and optimizing its geometry;on the other hand, we have introduced an active magnetic field noise suppression system to further suppress the magnetic field noise experienced by the ions. These efforts reduced the ambient magnetic field noise by about 10000 times, significantly reduced the linewidth of the clock transition spectrum, improved the stability of the portable40Ca+optical clock, and created the conditions for using portable optical clocks in non-laboratory magnetic field environments. This active magnetic field suppression scheme has the advantages of simple installation and wide applicability.

A cryogenic radio-frequency ion trap for a 40Ca^(+) optical clock

A liquid-nitrogen cryogenic40Ca^(+)optical clock is presented that is designed to greatly reduce the blackbody radiation(BBR) shift. The ion trap, the electrodes and the in-vacuum BBR shield are installed under the liquid-nitrogen container,keeping the ions in a cryogenic environment at liquid-nitrogen temperature. Compared with the first design in our previous work, many improvements have been made to increase the performance. The liquid-nitrogen maintenance time has been increased by about three times by increasing the volume of the liquid-nitrogen container;the trap position recovery time after refilling the liquid-nitrogen container has been decreased more than three times by using a better fixation scheme in the liquid-nitrogen container;and the magnetic field noise felt by the ions has been decreased more than three times by a better design of the magnetic shielding system. These optimizations make the scheme for reducing the BBR shift uncertainty of liquid-nitrogen-cooled optical clocks more mature and stable, and develop a stable lock with a narrower linewidth spectrum,which would be very beneficial for further reducing the overall systematic uncertainty of optical clocks.

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions

With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations.

Mathematical Representation of WECC Composite Load Model

Composite load model of Western Electricity Coordinating Council(WECC)is a newly developed load model that has drawn great interest from the industry.To analyze its dynamic characteristics with both mathematical and engineering rigors,a detailed mathematical model is needed.Although composite load model of WECC is available in commercial software as a module and its detailed block diagrams can be found in several public reports,there is no complete mathematical representation of the full model in literature.This paper addresses a challenging problem of deriving detailed mathematical representation of composite load model of WECC from its block diagrams.In particular,we have derived the mathematical representation of the new DERA model.The developed mathematical model is verified using both MATLAB and PSS/E to show its effectiveness in representing composite load model of WECC.The derived mathematical representation serves as an important foundation for parameter identification,order reduction and other dynamic analysis.