Innovation leading development:a glimpse into three-dimensional bioprinting in Israel

Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical printing.It has also been employed in various advanced industrial areas.The development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative bioproducts.However,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and biodegradability.In this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D printing.Therefore,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced applications.Israel,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting field.This review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue engineering.This paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide self-assembly.Undoubtedly,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

Research on the Value Positioning of University Library Based on Customer Delivered Value

With the rise of various new reading media and the rapid development of the digitization of paper resources,the traditional function positioning of university libraries based on information query is facing unprecedented challenges.How to deal with the change of social information?The library should be demand-oriented,re-examine its own value and find a new starting point.With the help of the concept of customer delivered value and based on 4P theory,this paper constructs the value chain of university library from the dimensions of product,image,personnel and service,and forms a multi-dimensional development positioning system.

Construction of Smart Library Based on the Agricultural Information from Metaverse Horizon

Metaverse is a virtual world,but it is possible and even becomes a trend that metaverse interacts with the real world along with the sci-tech and social development.Smart library is a main direction of modern library development,from informatization to digitization and then intelligent-based,modernization of library has been improved qualitatively.Emergence of metaverse brings a brand-new horizon to the generation and application of agricultural information,this paper made primary explorations the requirements and action mechanism of agricultural information on the construction of smart library within the external constraint of metaverse.

Effects of different processing methods on the lipid composition of hazelnut oil:a lipidomics analysis

Although hazelnut oil is rich in nutrients,its quality is greatly affected by how it is processed.However,no studies to date have comprehensively analyzed the lipid composition of hazelnut oil using different processing methods.Here,we conducted a lipidomics analysis using UPLC-QTOF-MS to characterize the lipid composition of cold-pressed hazelnut oil(CPO),ultrasonic-assisted hexane hazelnut oil(UHO)and enzyme-assisted aqueous hazelnut oil(EAO).A total of 10 subclasses of 98 lipids were identified,including35 glycerolipids(GLs),56 glycerophospholipids(GPs)and 7 sphingolipids(SPs).The total lipid and GL content were the highest in CPO,GP content was the highest in UHO and the ceramide content in SPs was most abundant in EAO.Multivariate statistical analysis showed that the lipid profiles of hazelnut oil prepared with different processing methods varied.Twelve significantly different lipids(TAG 54:3,TAG 52:2,TAG54:4,TAG 54:2,TAG 52:3,TAG 54:5,DAG 36:2,DAG 36:4,DAG 36:3,PC 36:2,PA 36:2 and PE 36:3)were identified,and these lipids could potentially be used as biomarkers to distinguish between hazelnut oil subjected to different processing methods.Our results provide useful information for hazelnut oil applications and new insight into the effects of edible oil processing.

A new species and a newly recorded species of the genus Megaselia Rondani(Diptera:Phoridae)from China

A new species of the genus Megaselia Rondani(Diptera:Phoridae),M.lanceoseta sp.nov.,from Heilongjiang,China,is described.The main diagnosis characters are as follows:anepisternum hairy,without bristles;notopleuron with three bristles,without notopleural cleft;scutellum with two pairs of bristles;epandrium with robust hairs;each cercus with two down-curved bristles;proctiger with two long,willow-leaf-shaped terminal bristles.The species Megaselia humeralis(Zetterstedt)is newly recorded from China.The type specimens are deposited in the Natural History Museum of Shenyang University(NMSU),Shenyang,China.

The actin motor protein OsMYA1 associates with OsExo70H1 and contributes to rice secretory defense by modulating OsSyp121 distribution

Magnaporthe oryzae(M.oryzae)is a devastating hemibiotrophic pathogen.Its biotrophic invasive hyphae(IH)are enclosed in the extrainvasive hyphal membrane produced by plant cells,thus generating a front line of the battlefield between the pathogen and the host plants.In plants,defense-related complexes such as proteins,callose-rich materials and vesicles,are directionally secreted to this interface to confer defense responses,but the underlying molecular mechanism is poorly understood.In this study,we found that a Myosin gene,Myosin A1(OsMYA1),contributed to rice defense.The OsMYA1 knockout mutant exhibited decreased resistance to M.oryzae infection.OsMYA1 localizes to the actin cytoskeleton and surrounds the IH of M.oryzae.OsMYA1 interacts with an exocyst subunit,OsExo70H1,and regulates its accumulation at the plasma membrane(PM)and pathogen–plant interface.Furthermore,OsExo70H1 interacted with the rice syntaxin of the plants121 protein(OsSyp121),and the distribution of OsSyp121 to the PM or the pathogen–plant interface was disrupted in both the OsMYA1 and OsExo70H1 mutants.Overall,these results not only reveal a new function of OsMYA1 in rice blast resistance,but also uncover a molecular mechanism by which plants regulate defense against M.oryzae by OsMYA1-initiated vesicle secretory pathway,which originates from the actin cytoskeleton to the PM.

Supramolecular Bonding Competition Enabled Nanostructure Evolution and Mechanical Reinforcement

In this work,competition between different supramolecular interactions is investigated based on a fibrous crystal composed of hydrogen-bonded cyanuric acid(CA)and amidinothiourea(ADT).Melamine(M)is found to prevail over ADT and bond to CA due to its stronger triple H-bonding affiliation,forming hollow microtubes assembled by oriented CAM crystalline arrays,as guided by the directionality of peripheral hydrogen bonds.Furthermore,competitive interaction between hydrogen bonding and ionic/covalent bonding is demonstrated by mixing Ag+ions with the CA-ADT fibers,where sulfur atoms are abstracted from ADT molecules to produce Ag_(2)S ligaments.The in situ-formed Ag_(2)S serves as a binding glue to generate CA-ADT/Ag_(2)S composites with significantly enhanced mechanical strength compared to the pristine CA-ADT fiber pellet.

Systematic investigation of nucleon optical model potentials in(p,d)transfer reactions

The consistent three-body model reaction methodology(TBMRM)proposed by J.Lee et al.[Phys.Rev.C 69,064313(2004);Phys.Rev.C 73,044608(2006);Phys.Rev.C 75,064320(2007)],which includes adopting the simple zero-range adiabatic wave approximation,constraining the single-particle potentials using modern Hartree-Fock calculations,and using global nucleon optical model potential(OMP)geometries,are widely applied in systematic studies of transfer reactions.In this study,we investigate the influence of different nucleon OMPs in extracting spectroscopic factors(SFs)from(p,d)reactions.Our study covers 32 sets of angular distribution data of(p,d)reactions on four targets and a large range of incident energies(20-200 MeV/nucleon).This study uses two semi-microscopic nucleon OMPs,i.e.,Jeukenne,Lejeune,and Mahaux(JLM)[Phys.Rev.C 16,80(1977);Phys.Rev.C 58,1118(1998)]and CTOM[Phys.Rev.C 94,034606(2016)],and a pure microscopic nucleon potential,i.e.,WLH[Phys.Rev.Lett.127,182502(2021)].The results are compared with those using the phenomenological global optical potential KD02[Nucl.Phys.A 713,231(2003)].We find that the incident energy dependence of spectroscopic factors extracted from(p,d)reactions is evidently suppressed when microscopic OMPs are employed for ^(12)C,^(28)Si,and 40Ca.In addition,spectroscopic factors extracted using the systematic microscopic optical potential CTOM based on the Dirac-Brueckner-Hartree-Fock theory are more in line with the results obtained from(e,e′p)measurements,except for 16O and ^(40)Ca at high energies(>100 MeV),necessitating an exact treatment of double-magic nuclei.The results obtained by using the pure microscopic optical potential,WLH,based on the EFT theory show the same trend as those of CTOM but are generally higher.The JLM potential,which relies on simplified nuclear matter calculations with old-fashioned bare interactions,produces results that are very similar to those of the phenomenological potential KD02.Our results indicate that modern microscopic OMPs are reliable tools for probing the nuclear structure using transfer reactions across a wide energy range.

Pyrite Concretions in the Lower Cambrian Niutitang Formation,South China:Response to Hydrothermal Activity

The Early Cambrian Niutitang Formation is characterized by wide distribution of black shales on Yangtze Block,South China.Here we have reported the pyrite concretions in the bottom of the Niutitang Formation deposited in the slope-basin environment of Yangtze Block.The pyrite concretion was mainly composed of pyrite associated with hydrothermal minerals(barite,hyalophane,tetrahedrite),followed by quartz and organic matter.Trace elements Mo and U displayed significant enrichment(enrichment factors > 10),indicating the euxinic bottom water condition.Cu,Ni,and excess Ba concentrations were relatively high,denoting high primary productivity.In-situ sulfur isotope compositions of pyrite concretions δ34Spy) showed little variations(13.2‰–19.4‰) and small fractionations compared to coeval seawater δ34Sso4.Petrological and geochemical analyses indicated the pyrite concretions were formed in the sediment-water interface during the early diagenesis,with H2S diffusing from the euxinic water,and influenced by hydrothermal activity leading to the coexistence of barite,hyalophane,and tetrahedrite.These results imply euxinic bottom water featured by high primary productivity and increasing riverine flux of sulfate from chemical weathering during the Early Cambrian.

Geophysical and orbital environments of asteroid 4692192016 HO3

Asteroid 469219 Kamo'oalewa,also named 2016 HO3,is a small-size fast-rotating near-Earth asteroid,which is a potential target for future explorations.Owing to its weak gravity and fast spin rate,the dynamics on the surface or in the vicinity of 2016 HO3 are significantly different from those of planets or other small bodies explored in previous missions.In this study,the geophysical and orbital environments of 2016 HO3 were investigated to facilitate a potential mission design.First,the geormnetric and geopotential topographies of 2016 HO3 were examined using difterent shape models.The liftoff and escape conditions on its fast-rotating surface were investigated.Then,the periodic orbits around 2016 HO3 were studied in the asteroid-fixed frame and the Sun-asteroid frame considering the solar radiation pressure.The stable regions of the terminator orbits were discussed using different parameters.Finally,the influence of the nonspherical shape on the terminator orbits was examined.The precise terminator orbits around a real shape model of 2016 HO3 were obtained and verified in the high-fidelity model.This study shows that the polar region of 2016 HO3 is the primary region for landing or sampling,and the terminator orbits are well suited for global mapping and measurements of 2016 HO3.The analysis and methods can also serve as references for the exploration of other small fast-rotating bodies.

Regularity for 3-D MHD Equations in Lorentz Space L^(3,∞)

.The regularity for 3-D MHD equations is considered in this paper,it is proved that the solutions(v,B,p)are Holder continuous if the velocity field v∈L^(∞)(0,T;L^(3,∞)_(x)(R^(3))with local small condition r^(-3)|{x∈B_(r)(x_(0):|v(x,t_(0))|>εr^(-1)}|≤ε and the magnetic field B∈L^(∞)(0,T;VMO^(-1)(R^(3)).

Insights into Pore Structure and Fractal Characteristics of the Lower Cambrian Niutitang Formation Shale on the Yangtze Platform,South China

Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential.To better illustrate the pore structure and fractal characteristics of shale,a series of experiments were conducted on outcrop samples from the Lower Cambrian Niutitang Formation on Yangtze Platform,including X-ray diffraction(XRD),field-emission scanning electron microscopy(FE-SEM) and low-temperature nitrogen adsorption.Frenkel-Halsey-Hill(FHH) model was adopted to calculate the fractal dimensions.Furthermore,the relationships between fractal dimensions and pore structure parameters and mineral composition are discussed.FE-SEM observation results show that interparticle pores are most developed in shale,followed by intraparticle pores.This study identified the fractal dimensions D1(ranging from 2.558 0 to 2.710 2) and D2(ranging from 2.541 5 to 2.765 2).The pore structure of the Niutitang Formation shale is primarily controlled by quartz and clay content.Fractal dimensions are able to characterize the pore structure complexity of Niutitang Formation shale because D1 and D2 correlate well with average pore diameter and quartz content.

Family involvement, family member composition and firm innovation

Based on the data of Chinese listed family firms from 2008 to 2016,we investigate the impact of family involvement on firm innovation and the moderating effect of family member composition.The results show that increased family involvement significantly reduces R&D investment intensity and the number of patent applications.With the increased richness of the kinship of family members involved in management,the negative impact of family involvement on patent applications is weakened,but family member composition does not have a significant moderating effect on the relationship between family involvement and R&D investment intensity.Further analysis shows that the number of invention patent applications decreases as the degree of family involvement increases,but family involvement has no significant effect on utility model patent and design patent applications.Family member composition has a significant moderating effect on the relationship between family involvement and invention patent applications.The results have value as a reference for exploring how family involvement affects firm innovation and can also help the actual controller to take effective measures to optimize family member composition and improve the innovation performance of family firms.

Variations in concentrations and bioavailability of heavy metals in rivers caused by water conservancy projects： Insights from water regulation of the Xiaolangdi Reservoir in the Yellow River

Water regulation of the Xiaolangdi Reservoir of the Yellow River was chosen as a case to investigate variations in concentrations and bioavailability of heavy metals caused by water conservancy projects in rivers. Water and suspended sediment（SPS） samples were collected at downstream sampling sites along the river during this period. Concentrations and speciation of Zn, Cr, Cu, Ni, and Pb in water and SPS samples were analyzed, and their bioaccumulation was studied with Daphnia magna. This study indicated that the exchangeable and carbonatebound fractions of heavy metals in SPS decreased along the studied stretch, and the dissolved heavy metal concentrations increased along the river with 1.6–15 folds. This is because sediment resuspension increased along the river during water regulation, giving rise to the increase of heavy metal release from SPS. The dissolved Zn, Cu, Ni, and Pb concentrations were significantly positively correlated with SPS concentrations, and their increase along the river was greater than Cr. The body burdens of heavy metals in D. magna exposed into samples collected from the reservoir outlet were 1.3–3.0 times lower than those from downstream stations, suggesting that the heavy metal bioavailability increased during water regulation.This should be considered in the reservoir operation.

新冠疫情期间保障急诊医疗服务质量的探究--基于Python网络爬虫可视化分析公众对疫情期间急诊延误事故的反应

目的基于公众对疫情期间急诊延误事故的反应,分析疫情期间如何保障急诊医疗服务质量。方法采用Python网络爬虫抓取知乎平台下公众对某一疫情期间急诊延误事故相关问题的回答,采用词云图可视化展现回答内容,并统计公众关注的导致疫情期间急诊服务质量下降的原因、公众对法规改进和社区医疗的建议。结果公众普遍认为,此次急诊事故的发生与疫情防控密切相关。公众关注的因素主要包括私立医院的营业性质、法规不合理、行政管理者、医院基层和社区的过失。通过进一步分析讨论可知,疫情对急诊就诊的影响主要在于急诊就诊资源减少、急诊流程延长和交叉感染风险增加等。私立医院存在大量监管漏洞,监管机构可以从检查方式和准入标准等方面强化监督。卫生行政管理部门应当合理统筹医疗资源,建设实时应急管理信息发布通道并严惩急诊拒诊。医院应当优化医院结构,设置不同等级的院感风险区,并设立专门值班室。社区卫生服务中心应当做好预检分流工作,落实双向转诊并优化医疗配置。结论从政府、医院、社区多角度协同保障疫情期间的急诊医疗质量,可改善现有卫生管理的不足。