Cancer remains a leading cause of mortality worldwide,with conventional treatments,such as chemotherapy and immunotherapy,exhibiting limitations,such as drug resistance and immune evasion.Therefore,novel therapeutic s...Cancer remains a leading cause of mortality worldwide,with conventional treatments,such as chemotherapy and immunotherapy,exhibiting limitations,such as drug resistance and immune evasion.Therefore,novel therapeutic strategies are required.Sonodynamic therapy has emerged as an innovative approach in which sonosensitizers are activated by ultrasound to achieve antitumor effects through mechanisms,such as cavitation,thermal effects,and reactive oxygen species generation.Notably,sonodynamic therapy also exhibits immunomodulatory effects and strongly impacts the tumor microenvironment and immune system in the body.The immune effects of sonodynamic therapy indicate that it can be applied with immunotherapy to exert synergistic effects.This review describes the design of sonosensitizers and basic mechanisms of sonodynamic therapy,highlighting their immune effects and recent advancements in sonodynamic therapy-based cancer immunotherapy.In addition,we introduce the applications of gas and metabolic regulation therapies in sonodynamic immunotherapy.展开更多
Ultrasonography is an important complement to clinical diagnosis,and the application of microbubbles effectively improved diagnostic accuracy in echography.In scientific research,the sizes of microbubbles range from n...Ultrasonography is an important complement to clinical diagnosis,and the application of microbubbles effectively improved diagnostic accuracy in echography.In scientific research,the sizes of microbubbles range from nanometers to microns.By optimizing the fabrication process,bubble sizes and ultrasound parameters,microbubbles can also be used for drug delivery and therapeutic monitoring.In this review,we summarize the recent advances in the diagnosis and treatment of microbubbles according to their different components.Modification of microbubble shells allows for more accurate imaging and detection and the combined utilization of US-targeted MB destruction(UTMD)allows for non-invasive,precise and targeted delivery of drug molecules to pathological tissues.These features pave the way for the emerge of theranostic microbubbles by combination of functional compositions and the application of multifunctional materials.Theranostic microbubbles allow for the simultaneous process of diagnosis,visualization of drug delivery and therapeutic monitoring.Ultimately,theranostic microbubbles are promising in clinical practice and would enhance contrast-enhanced US(CEUS)to a new qualitative level.展开更多
基金supported by the National Natural Science Foundation of China[grant number 82272003]the Sichuan Science and Technology Program[grant number 2023YFH0031].
文摘Cancer remains a leading cause of mortality worldwide,with conventional treatments,such as chemotherapy and immunotherapy,exhibiting limitations,such as drug resistance and immune evasion.Therefore,novel therapeutic strategies are required.Sonodynamic therapy has emerged as an innovative approach in which sonosensitizers are activated by ultrasound to achieve antitumor effects through mechanisms,such as cavitation,thermal effects,and reactive oxygen species generation.Notably,sonodynamic therapy also exhibits immunomodulatory effects and strongly impacts the tumor microenvironment and immune system in the body.The immune effects of sonodynamic therapy indicate that it can be applied with immunotherapy to exert synergistic effects.This review describes the design of sonosensitizers and basic mechanisms of sonodynamic therapy,highlighting their immune effects and recent advancements in sonodynamic therapy-based cancer immunotherapy.In addition,we introduce the applications of gas and metabolic regulation therapies in sonodynamic immunotherapy.
基金supported by the National Natural Science Foundation of China-Sichuan Joint Fund Key Program(No.NSFCU21A20417)the National Natural Science Foundation of China(Nos.NSFC31930067,81971622,82272003)the 135 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002,China)。
文摘Ultrasonography is an important complement to clinical diagnosis,and the application of microbubbles effectively improved diagnostic accuracy in echography.In scientific research,the sizes of microbubbles range from nanometers to microns.By optimizing the fabrication process,bubble sizes and ultrasound parameters,microbubbles can also be used for drug delivery and therapeutic monitoring.In this review,we summarize the recent advances in the diagnosis and treatment of microbubbles according to their different components.Modification of microbubble shells allows for more accurate imaging and detection and the combined utilization of US-targeted MB destruction(UTMD)allows for non-invasive,precise and targeted delivery of drug molecules to pathological tissues.These features pave the way for the emerge of theranostic microbubbles by combination of functional compositions and the application of multifunctional materials.Theranostic microbubbles allow for the simultaneous process of diagnosis,visualization of drug delivery and therapeutic monitoring.Ultimately,theranostic microbubbles are promising in clinical practice and would enhance contrast-enhanced US(CEUS)to a new qualitative level.
