Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder

Thalamocortical circuitry has a substantial impact on emotion and cognition.Previous studies have demonstrated alterations in thalamocortical functional connectivity(FC),characterized by region-dependent hypo-or hyper-connectivity,among individuals with major depressive disorder(MDD).However,the dynamical reconfiguration of the thalamocortical system over time and potential abnormalities in dynamic thalamocortical connectivity associated with MDD remain unclear.Hence,we analyzed dynamic FC(dFC)between ten thalamic subregions and seven cortical subnetworks from resting-state functional magnetic resonance images of 48 patients with MDD and 57 healthy controls(HCs)to investigate time-varying changes in thalamocortical FC in patients with MDD.Moreover,dynamic laterality analysis was conducted to examine the changes in functional lateralization of the thalamocortical system over time.Correlations between the dynamic measures of thalamocortical FC and clinical assessment were also calculated.We identified four dynamic states of thalamocortical circuitry wherein patients with MDD exhibited decreased fractional time and reduced transitions within a negative connectivity state that showed strong correlations with primary cortical networks,compared with the HCs.In addition,MDD patients also exhibited increased fluctuations in functional laterality in the thalamocortical system across the scan duration.The thalamo-subnetwork analysis unveiled abnormal dFC variability involving higher-order cortical networks in the MDD cohort.Significant correlations were found between increased dFC variability with dorsal attention and default mode networks and the severity of symptoms.Our study comprehensively investigated the pattern of alteration of the thalamocortical dFC in MDD patients.The heterogeneous alterations of dFC between the thalamus and both primary and higher-order cortical networks may help characterize the deficits of sensory and cognitive processing in MDD.

Erratum to:Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder

The article(Zheng et al.,2024)unfortunately contained a mistake:in Table 3,four"I"elements in the last"LF in thalamus"column are mistaken.The four arrows should be"↑"in the following correctversion of Table3.

Boosting external quantum efficiency of a WSe_(2) photodetector across visible and NIR spectra through harnessing plasmonic hot electrons

The layered two-dimensional material tungsten diselenide(WSe_(2))has triggered tremendous interests in the field of optoelectronic devices due to its exceptional carrier transport property.Nevertheless,the limited absorption of WSe_(2) in the near infrared(NIR)band poses a challenge for the application of WSe_(2) photodetectors in night vision,telecommunication,etc.Herein,the enhanced performance of the WSe_(2) photodetector is demonstrated through the incorporation of titanium nitride nanoparticles(TiN NPs),complemented by an atomically-thick Al_(2)O_(3) layer that aids in suppressing the dark current.It is demonstrated that TiN NPs can dramatically enhance the absorption of light in the proposed WSe_(2) photodetector in the NIR regime.This enhancement boosts photocurrent responses through the generation of plasmonic hot electrons,leading to external quantum efficiency(EQE)enhancement factors of 379.66%at 850 nm and 178.47%at 1550 nm.This work presents,for the first time,to our knowledge,that the WSe_(2) photodetector is capable of detecting broadband light spanning from ultraviolet to the telecommunication range,all achieved without the reliance on additional semiconductor materials.This achievement opens avenues for the advancement of cost-effective NIR photodetectors.