Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal comfort.However,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the li...Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal comfort.However,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal conductivity.To compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with PCMs.Based on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were studied.Taking the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter region.Results show that the Trombe wall helped PCMs complete the phase change process effectively.Trombe wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,respectively.Compared with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions.展开更多
This paper investigates the free cash flow productivity of SOEs compared with non-SOEs and examines its possible determinants.We find that SOEs have slightly weak free cash flow productivity but significantly stronger...This paper investigates the free cash flow productivity of SOEs compared with non-SOEs and examines its possible determinants.We find that SOEs have slightly weak free cash flow productivity but significantly stronger than non-SOEs.Similar performance exists among commercial class I and II SOEs and public-benefit SOEs.Further analyses suggest that firm size,age,sales growth,ownership concentration,government subsidies,and industry monopoly factors cannot explain this phenomenon.The common driver for all types of SOEs to generate stronger free cash flows than non-SOEs is their stronger expense control capability.展开更多
Recently,research on two-dimensional(2D)semiconductors has begun to translate from the fundamen-tal investigation into rudimentary functional circuits.In this work,we unveil the first functional MoS2 artificial neural...Recently,research on two-dimensional(2D)semiconductors has begun to translate from the fundamen-tal investigation into rudimentary functional circuits.In this work,we unveil the first functional MoS2 artificial neural network(ANN)chip,including multiply-and-accumulate(MAC),memory and activation function circuits.Such MoS2 ANN chip is realized through fabricating 818 field-effect transistors(FETs)on a wafer-scale and high-homogeneity MoS2 film,with a gate-last process to realize top gate structured FETs.A 62-level simulation program with integrated circuit emphasis(SPICE)model is utilized to design and optimize our analog ANN circuits.To demonstrate a practical application,a tactile digit sensing recognition was demonstrated based on our ANN circuits.After training,the digit recognition rate exceeds 97%.Our work not only demonstrates the protentional of 2D semiconductors in wafer-scale inte-grated circuits,but also paves the way for its future application in AI computation.展开更多
Immune checkpoint inhibitors(ICIs)have revolutionized the approach to advanced and locally advanced non-small-cell lung cancer(NSCLC).Antibodies blocking inhibitory immune checkpoints,such as programmed death 1(PD-1)a...Immune checkpoint inhibitors(ICIs)have revolutionized the approach to advanced and locally advanced non-small-cell lung cancer(NSCLC).Antibodies blocking inhibitory immune checkpoints,such as programmed death 1(PD-1)and its ligand(PD-L1),have remarkable antitumor efficacy and have been approved as a standard first-or second-line treatment in non-oncogene-addicted advanced NSCLC.The successful application of immunotherapy in advanced lung cancer has motivated researchers to further evaluate its clinical role as a neoadjuvant setting for resectable NSCLC and for improved long-term overall survival and curative rates.In this review,we discuss the efforts that incorporate ICIs into the treatment paradigm for surgically resectable lung cancer.We reviewed the early-phase results from neoadjuvant clinical trials,the landscape of the majority of ongoing phase III trials,and discuss the prospects of ICIs as a curative therapy for resectable lung cancer.We also summarized the potential biomarkers and beneficiaries involved in the current study,as well as the remaining unresolved challenges for neoadjuvant immunotherapy.展开更多
A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic longitude and latitude was proposed.The vertical and horizontal geodesic coordinates measured with length were defined as coor...A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic longitude and latitude was proposed.The vertical and horizontal geodesic coordinates measured with length were defined as coordinate parameters,but the two families of coordinate curves were still meridians and parallel circles.The first fundamental form on the ellipsoidal surface and its three coefficients were deduced by the geodesic coordinate.The formula for the latitudinal scale factor of length for geodetic parallel lines was derived,by which the obtained result conformed to that standard value calculated from geodetic latitude,and it is applicable in the range of 400 km from north to south.Therefore,it lays the foundation for establishing the differential equation and differential relationship based on this type of coordinate parameters;and consequently,it is convenient and accurate enough to operate on the ellipsoidal surface in this new form of geodetic coordinate system.展开更多
The use of phase change materials(PCMs)in building enclosures is an efficient way to reduce the heat gain and/or loss in summer and winter.It was evident that the thermal performance of buildings with PCMs was affecte...The use of phase change materials(PCMs)in building enclosures is an efficient way to reduce the heat gain and/or loss in summer and winter.It was evident that the thermal performance of buildings with PCMs was affected by the outdoor air temperature significantly.However,the influence of humidity,which was serious in the humid subtropical climate was unclear.To explore the effect of PCMs under a humid subtropical climate,the thermal performance of a lightweight building outfitted with PCMs with a melting temperature of 25°C was investigated.The actual outdoor air temperature with a humidity of 40-90 RH%and wind velocity of 2-6 m/s blowing from the east,west,south,and north was assumed for the performance assessment.A simulated model was developed using EnergyPlus and verified against experimental data.The energy savings by using PCMs was reduced from 3.9%to 2.6%when the outdoor humidity increased from 40 to 90 RH%in summer.However,the savings was not obvious in winter.Annual energy savings decreased from 1.64%to 1.32%with humidity increasing from 40 to 90 RH%.For annual condition,the average energy savings was reduced from 1.43%to 0.92%when the wind speed increased from 2 m/s to 6 m/s.From an economic point of view,the investment payback period was less than 10 years when the PCM price was lower than 18.0 Yuan/kg.展开更多
Objective:Cardiac damage is commonly reported in patients with coronavirus disease 2019(COVID-19)but its prevalence and impact on the long-term survival of patients remain uncertain.This study aimed to explore the pre...Objective:Cardiac damage is commonly reported in patients with coronavirus disease 2019(COVID-19)but its prevalence and impact on the long-term survival of patients remain uncertain.This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.Methods:A single-center,retrospective cohort study was performed at the Affiliated Hospital of Jianghan University.Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27,2019 to April 25,2020 were collected.Demographic,clinical,laboratory,electrocardiogram,treatment data and all-cause mortality during follow-up were collected and analyzed.Results:Of the 766 patients with moderate to critically ill COVID-19,86(11.2%)died after a mean follow-up of 72.8 days.Myocardial injury occurred in 94(12.3%)patients.The mortality rate was 64.9%(61/94)and 3.7%(25/672)in patients with and without myocardial injury,respectively.Cox regression showed that myocardial injury was an independent risk factor for mortality(hazard ratio:8.76,95%confidence interval:4.76–16.11,P<0.001).Of the 90 patients with myocardial injury with electrocardiogram results,sinus tachycardia was present in 29,bundle branch block in 26,low voltage in 10,and abnormal T-wave in 53.Conclusions:COVID-19 not only involves pneumonia but also cardiac damage.Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.展开更多
基金supported by the National Key Research and Devel-opment Program of China(2018YFE0111200)the National Natural Science Foundation of China(52078053,51608051)+4 种基金the Science and Technology Department of Hunan(2019JJ30027,2020GK4057)the Changsha City Fund for Distinguished and Innovative Young Scholars(kq2106036)the Hunan Provincial Science and Technology Depart-ment(2020WK2012,2021JJ40584)the Education Department of Hu-nan Province(19C0073)the Chenzhou Municipal Science and Tech-nology Bureau(2021SFQ01).
文摘Trombe wall and phase change materials(PCMs)are two effective ways to regulate indoor thermal comfort.However,Trombe wall surfers from overheating in summer and PCMs suffer from low heat transfer rate caused by the limited thermal conductivity.To compensate the shortcomings of the two methods,this paper proposed a Trombe wall system integrated with PCMs.Based on a light-weight building envelope in Changsha,China,the thermal comfort of 10 kinds of Trombe wall systems with PCMs with a melting temperature of 18-28℃ were studied.Taking the integrated indoor discomfort duration(I_(D)),integrated indoor discomfort degree-hour(I_(DH)),indoor air temperature(T_(in)),PCM liquid fraction(γ)and heat flux across wall(q)as evaluation indexes,the indoor thermal comfort was assessed in hot summer and cold winter region.Results show that the Trombe wall helped PCMs complete the phase change process effectively.Trombe wall with PCM25 next to the wall inner surface possessed the lowest annual I_(D) and I_(DH),as 2877 h and 12,974℃·h,respectively.Compared with the values in a traditional building,the I_(D) and I_(DH) were reduced by 7.01% and 14.14%.In order to give full play to the heat storage and heat release of the Trombe wall with PCMs,PCMs with phase change temperature 7℃ lower than the peak ambient temperature in summer or 8℃ higher than the winter night temperature was recommended according to regional climate conditions.
基金support from the National Natural Science Foundation of China(Project No.71672098)Accounting Master Program of the Ministry of Finance of China(2015)and the Tsinghua University School of Economics and Management Research Grant(Project No.2020051009).
文摘This paper investigates the free cash flow productivity of SOEs compared with non-SOEs and examines its possible determinants.We find that SOEs have slightly weak free cash flow productivity but significantly stronger than non-SOEs.Similar performance exists among commercial class I and II SOEs and public-benefit SOEs.Further analyses suggest that firm size,age,sales growth,ownership concentration,government subsidies,and industry monopoly factors cannot explain this phenomenon.The common driver for all types of SOEs to generate stronger free cash flows than non-SOEs is their stronger expense control capability.
基金the National Key Research and Development Program of China(2016YFA0203900,2018YFB2202500)Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-07-E00077)+3 种基金Shanghai Municipal Science and Technology Commission(18JC1410300,21DZ1100900)Research Grant Council of Hong Kong(15205619)the National Natural Science Foundation of China(61925402,61934008,and 6210030233)the Natural Science Foundation of Shanghai(21ZR1405700)。
文摘Recently,research on two-dimensional(2D)semiconductors has begun to translate from the fundamen-tal investigation into rudimentary functional circuits.In this work,we unveil the first functional MoS2 artificial neural network(ANN)chip,including multiply-and-accumulate(MAC),memory and activation function circuits.Such MoS2 ANN chip is realized through fabricating 818 field-effect transistors(FETs)on a wafer-scale and high-homogeneity MoS2 film,with a gate-last process to realize top gate structured FETs.A 62-level simulation program with integrated circuit emphasis(SPICE)model is utilized to design and optimize our analog ANN circuits.To demonstrate a practical application,a tactile digit sensing recognition was demonstrated based on our ANN circuits.After training,the digit recognition rate exceeds 97%.Our work not only demonstrates the protentional of 2D semiconductors in wafer-scale inte-grated circuits,but also paves the way for its future application in AI computation.
文摘Immune checkpoint inhibitors(ICIs)have revolutionized the approach to advanced and locally advanced non-small-cell lung cancer(NSCLC).Antibodies blocking inhibitory immune checkpoints,such as programmed death 1(PD-1)and its ligand(PD-L1),have remarkable antitumor efficacy and have been approved as a standard first-or second-line treatment in non-oncogene-addicted advanced NSCLC.The successful application of immunotherapy in advanced lung cancer has motivated researchers to further evaluate its clinical role as a neoadjuvant setting for resectable NSCLC and for improved long-term overall survival and curative rates.In this review,we discuss the efforts that incorporate ICIs into the treatment paradigm for surgically resectable lung cancer.We reviewed the early-phase results from neoadjuvant clinical trials,the landscape of the majority of ongoing phase III trials,and discuss the prospects of ICIs as a curative therapy for resectable lung cancer.We also summarized the potential biomarkers and beneficiaries involved in the current study,as well as the remaining unresolved challenges for neoadjuvant immunotherapy.
基金supported by the National Natural Science Foundation of China(Grant No.40471114).
文摘A new form of geodetic coordinate system based on geodesic coordinates instead of geodetic longitude and latitude was proposed.The vertical and horizontal geodesic coordinates measured with length were defined as coordinate parameters,but the two families of coordinate curves were still meridians and parallel circles.The first fundamental form on the ellipsoidal surface and its three coefficients were deduced by the geodesic coordinate.The formula for the latitudinal scale factor of length for geodetic parallel lines was derived,by which the obtained result conformed to that standard value calculated from geodetic latitude,and it is applicable in the range of 400 km from north to south.Therefore,it lays the foundation for establishing the differential equation and differential relationship based on this type of coordinate parameters;and consequently,it is convenient and accurate enough to operate on the ellipsoidal surface in this new form of geodetic coordinate system.
基金This work was supported by the National Key R&D Plan(2018YFE0111200)National Natural Science Foundation of China(52078053,51308051)+2 种基金the Science and Technology Department of Hunan(2019JJ30027)Hunan Association for Science and Technology(2017TJQ05)the C hangsha City Fund for Distinguished and Innovative Young Scholars(kq1905038).
文摘The use of phase change materials(PCMs)in building enclosures is an efficient way to reduce the heat gain and/or loss in summer and winter.It was evident that the thermal performance of buildings with PCMs was affected by the outdoor air temperature significantly.However,the influence of humidity,which was serious in the humid subtropical climate was unclear.To explore the effect of PCMs under a humid subtropical climate,the thermal performance of a lightweight building outfitted with PCMs with a melting temperature of 25°C was investigated.The actual outdoor air temperature with a humidity of 40-90 RH%and wind velocity of 2-6 m/s blowing from the east,west,south,and north was assumed for the performance assessment.A simulated model was developed using EnergyPlus and verified against experimental data.The energy savings by using PCMs was reduced from 3.9%to 2.6%when the outdoor humidity increased from 40 to 90 RH%in summer.However,the savings was not obvious in winter.Annual energy savings decreased from 1.64%to 1.32%with humidity increasing from 40 to 90 RH%.For annual condition,the average energy savings was reduced from 1.43%to 0.92%when the wind speed increased from 2 m/s to 6 m/s.From an economic point of view,the investment payback period was less than 10 years when the PCM price was lower than 18.0 Yuan/kg.
基金supported by the Foundation of the Scientific Research Project of Wuhan Municipal Health Committee(WX17D39)。
文摘Objective:Cardiac damage is commonly reported in patients with coronavirus disease 2019(COVID-19)but its prevalence and impact on the long-term survival of patients remain uncertain.This study aimed to explore the prevalence of myocardial injury and assess its prognostic value in patients with COVID-19.Methods:A single-center,retrospective cohort study was performed at the Affiliated Hospital of Jianghan University.Data from 766 patients with confirmed COVID-19 who were hospitalized from December 27,2019 to April 25,2020 were collected.Demographic,clinical,laboratory,electrocardiogram,treatment data and all-cause mortality during follow-up were collected and analyzed.Results:Of the 766 patients with moderate to critically ill COVID-19,86(11.2%)died after a mean follow-up of 72.8 days.Myocardial injury occurred in 94(12.3%)patients.The mortality rate was 64.9%(61/94)and 3.7%(25/672)in patients with and without myocardial injury,respectively.Cox regression showed that myocardial injury was an independent risk factor for mortality(hazard ratio:8.76,95%confidence interval:4.76–16.11,P<0.001).Of the 90 patients with myocardial injury with electrocardiogram results,sinus tachycardia was present in 29,bundle branch block in 26,low voltage in 10,and abnormal T-wave in 53.Conclusions:COVID-19 not only involves pneumonia but also cardiac damage.Myocardial injury is a common complication and an independent risk factor for mortality in COVID-19 patients.