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Evaluation of microvascular reactivity with laser Doppler flowmetry in chronic kidney disease
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作者 Levente Babos zoltán járai jános nemcsik 《World Journal of Nephrology》 2013年第3期77-83,共7页
Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease(CKD).The complex process of accelerated athero- and arteriosclerosis in CKD is associated with this phenomenon,where en... Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease(CKD).The complex process of accelerated athero- and arteriosclerosis in CKD is associated with this phenomenon,where endothelial dysfunction(ED) is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry(LDF) enables us to study the microcirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia,local heating, iontophoresis, microdialysis or analysis of flowmotion. We would also like to summarize the available data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population. 展开更多
关键词 Chronic kidney disease Laser Doppler fowmetry Endothelial dysfunction IONTOPHORESIS Postoc clusive reactive hyperaemia Local heating MICRODIALYSIS Flowmotion
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