MicroRNAs(miRNAs)play an important regulatory role in neuronal growth and development.Different mi RNAs target different genes to protect neurons in different ways,such as by avoiding apoptosis,preventing degeneration...MicroRNAs(miRNAs)play an important regulatory role in neuronal growth and development.Different mi RNAs target different genes to protect neurons in different ways,such as by avoiding apoptosis,preventing degeneration mediated by conditional mediators,preventing neuronal loss,weakening certain neurotoxic mechanisms,avoiding damage to neurons,and reducing inflammatory damage to them.The high expression of mi RNAs in the brain has significantly facilitated their development as protective targets for therapy,including neuroprotection and neuronal recovery.mi RNA is indispensable to the growth and development of neurons,and in turn,is beneficial for the development of the brain and checking the progression of various diseases of the nervous system.It can thus be used as an important therapeutic target for models of various diseases.This review provides an introduction to the protective effects of mi RNA on neurons in case of different diseases or damage models,and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.展开更多
基金supported by the National Natural Science Foundation of China,No.81801208(to LSO)Science and Technology Program of Guangzhou,No.202102080053(to YF)+1 种基金Science and Technology Program of Guangzhou,No.202007030001(to YMT)Science and Technology Planning Project of Guangzhou,No.202102020027(to ZL)。
文摘MicroRNAs(miRNAs)play an important regulatory role in neuronal growth and development.Different mi RNAs target different genes to protect neurons in different ways,such as by avoiding apoptosis,preventing degeneration mediated by conditional mediators,preventing neuronal loss,weakening certain neurotoxic mechanisms,avoiding damage to neurons,and reducing inflammatory damage to them.The high expression of mi RNAs in the brain has significantly facilitated their development as protective targets for therapy,including neuroprotection and neuronal recovery.mi RNA is indispensable to the growth and development of neurons,and in turn,is beneficial for the development of the brain and checking the progression of various diseases of the nervous system.It can thus be used as an important therapeutic target for models of various diseases.This review provides an introduction to the protective effects of mi RNA on neurons in case of different diseases or damage models,and then provides reference values and reflections on the relevant treatments for the benefit of future research in the area.
