Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy varies.This review summarized the ability of various markers to pred...Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy varies.This review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical applications.As of October 25,2023,51 articles have been retrieved based on keyword predictions and HAIC.Sixteen eligible articles were selected for inclusion in this study.Comprehensive literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging testing.The above indicators and their combined forms showed excellent predictive effects in retrospective studies.This review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.展开更多
Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon fuel.However,the limited conductivity and stability b...Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon fuel.However,the limited conductivity and stability become the stumbling-block that prevents the development of it.The exploring of MOFsderived M-C materials starts a new chapter for the MOFs precursors,which provides a remarkable electronic connection between carbon matrix and metals/metal oxides.N-doped M-N-C with extensive M-N sites scattering into the carbon matrix are more popular because of their impressive contribution to catalytic activity and specific product selectivity.Nevertheless,Cu-N-C system remained undeveloped up to now.The lack of ideal precursor,the sensitivity of Cu to be oxidized,and the difficulties in the synthesis of small size Cu nanoparticles are thus known as the main barriers to the development of Cu-N-C electrocatalysts.Herein,a nitrogen-rich Cu-BTT MOF is employed for the derivation of N-doped Cu-N-CT composite electrocatalysts by the pyrolyze method.High-temperature pyrolysis product of Cu-N-C1100exhibits the best catalytic activity for productions of CO(-0.6 V vs.RHE,jCO=0.4 mA/cm^(2))and HCOOH(-0.9 V vs.RHE,jHCOOH=1.4 mA/cm^(2)).展开更多
基金Supported by the Research Fund of Beijing Tsinghua Changgung Hospital,No.12021C11016.
文摘Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy varies.This review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical applications.As of October 25,2023,51 articles have been retrieved based on keyword predictions and HAIC.Sixteen eligible articles were selected for inclusion in this study.Comprehensive literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging testing.The above indicators and their combined forms showed excellent predictive effects in retrospective studies.This review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.
基金supported by the National Natural Science Foundation of China(20171169)Six Talent Peaks Project in Jiangsu Province(No.2017-XNY-043)+1 种基金the projects funded by the High-Level Personnel Support Program of Yang-Zhou Universitythe Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘Cu-based MOFs,i.e.,HKUST-1,etc.,have been pertinently chosen as the pristine materials for CO_(2) ER due to the unique ability of copper for generation hydrocarbon fuel.However,the limited conductivity and stability become the stumbling-block that prevents the development of it.The exploring of MOFsderived M-C materials starts a new chapter for the MOFs precursors,which provides a remarkable electronic connection between carbon matrix and metals/metal oxides.N-doped M-N-C with extensive M-N sites scattering into the carbon matrix are more popular because of their impressive contribution to catalytic activity and specific product selectivity.Nevertheless,Cu-N-C system remained undeveloped up to now.The lack of ideal precursor,the sensitivity of Cu to be oxidized,and the difficulties in the synthesis of small size Cu nanoparticles are thus known as the main barriers to the development of Cu-N-C electrocatalysts.Herein,a nitrogen-rich Cu-BTT MOF is employed for the derivation of N-doped Cu-N-CT composite electrocatalysts by the pyrolyze method.High-temperature pyrolysis product of Cu-N-C1100exhibits the best catalytic activity for productions of CO(-0.6 V vs.RHE,jCO=0.4 mA/cm^(2))and HCOOH(-0.9 V vs.RHE,jHCOOH=1.4 mA/cm^(2)).
