Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon regeneration.Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal rege...Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon regeneration.Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal regenerative ability and disconnection of neural elements after injury,as well as the limited systemic drug delivery efficiency caused by blood spinal cord barrier.To develop an effective non-invasive treatment strategy for SCI in clinic,we generated an autologous plasma exosome(AP-EXO)based biological scaffold where AP-EXO was loaded with neuron targeting peptide(RVG)and growth-facilitating peptides(ILP and ISP).This scaffold can be targeted delivered to neurons in the injured area and elicit robust axon regrowth across the lesion core to the levels over 30-fold greater than naïve treatment,thus reestablish the intraspinal circuits and promote motor functional recovery after spinal cord injury in mice.More importantly,in ex vivo,human plasma exosomes(HP-EXO)loaded with combinatory peptides of RVG,ILP and ISP showed safety and no liver and kidney toxicity in the application to nude SCI mice.Combining the efficacy and safety,the AP-EXO-based personalized treatment confers functional recovery after SCI and showed immense promising in biomedical applications in treating SCI.It is helpful to expand the application of combinatory peptides and human plasma derived autologous exosomes in promoting regeneration and recovery upon SCI treatment.展开更多
The ＂island of inversion＂ has been known for over a quar- ter century, since Warburton et al. [1] proposed that nuclei with intruder ground states would constitute a 3x3 square with Z=10-12, N=20-22 in 1990. Uncover...The ＂island of inversion＂ has been known for over a quar- ter century, since Warburton et al. [1] proposed that nuclei with intruder ground states would constitute a 3x3 square with Z=10-12, N=20-22 in 1990. Uncovering the underlying inversion mechanism and exploring the scope of the island have attracted significant theoretical and experimental efforts in the following years. Now it is well known that the reduction of N=20 shell gap, which is likely caused by the strong nucleon-nucleon tensor interaction [2-5], allows the intrusion of neutron orbits from the pf shell into the sd shell and results in the inversion of the 2p-2h intruder and 0p-0h normal con- figurations of the nuclear ground states in this region. Mean- while, the original border of the ＂island of inversion＂ has been extended greatly [6-14].展开更多
Poverty-alleviation programs using solar energy(PAPSE)are poised to unlock unprecedented capital investments with significant potential to reconcile the energy–poverty–climate nexus.1 These programs are economically...Poverty-alleviation programs using solar energy(PAPSE)are poised to unlock unprecedented capital investments with significant potential to reconcile the energy–poverty–climate nexus.1 These programs are economically feasible because the costs of generating renewable energy have declined precipitously over the past decade;between 2010 and 2019,solar photovoltaiccosts decreased by 82%.Furthermore,the number of annual equivalent-use hours of sunlight in most countries exceeds 1200,meaning that PAPSE approaches are feasible in many places and can be undertaken independently from the power grid.展开更多
基金This work was supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100),ChinaNational Natural Science Foundation of China(81930070)+3 种基金National Natural Science Foundation of China(82102560)the Natural Science Foundation of Shandong Province,China(ZR2021QH097)the No.69 General Fund of China Postdoctoral Science Foundation(2021M691936)Talent project of Shandong University(22480082063100),China.
文摘Spinal cord injury(SCI)causes motor,sensory and automatic impairment due to rarely axon regeneration.Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal regenerative ability and disconnection of neural elements after injury,as well as the limited systemic drug delivery efficiency caused by blood spinal cord barrier.To develop an effective non-invasive treatment strategy for SCI in clinic,we generated an autologous plasma exosome(AP-EXO)based biological scaffold where AP-EXO was loaded with neuron targeting peptide(RVG)and growth-facilitating peptides(ILP and ISP).This scaffold can be targeted delivered to neurons in the injured area and elicit robust axon regrowth across the lesion core to the levels over 30-fold greater than naïve treatment,thus reestablish the intraspinal circuits and promote motor functional recovery after spinal cord injury in mice.More importantly,in ex vivo,human plasma exosomes(HP-EXO)loaded with combinatory peptides of RVG,ILP and ISP showed safety and no liver and kidney toxicity in the application to nude SCI mice.Combining the efficacy and safety,the AP-EXO-based personalized treatment confers functional recovery after SCI and showed immense promising in biomedical applications in treating SCI.It is helpful to expand the application of combinatory peptides and human plasma derived autologous exosomes in promoting regeneration and recovery upon SCI treatment.
基金supported by the National Natural Science Foundation of China(Grant Nos.11575006,11675003,11375017,11235001,11335002, 11375015,11320101004,and 11461141002)the China Postdoctoral Science Foundation(Grant Nos.2015M580007,and 2016T90007)the Chinese Major State Basic Research Development Program(Grant No.2013CB834400)
文摘The ＂island of inversion＂ has been known for over a quar- ter century, since Warburton et al. [1] proposed that nuclei with intruder ground states would constitute a 3x3 square with Z=10-12, N=20-22 in 1990. Uncovering the underlying inversion mechanism and exploring the scope of the island have attracted significant theoretical and experimental efforts in the following years. Now it is well known that the reduction of N=20 shell gap, which is likely caused by the strong nucleon-nucleon tensor interaction [2-5], allows the intrusion of neutron orbits from the pf shell into the sd shell and results in the inversion of the 2p-2h intruder and 0p-0h normal con- figurations of the nuclear ground states in this region. Mean- while, the original border of the ＂island of inversion＂ has been extended greatly [6-14].
基金supported by the Major Program of the National Natural Science Foundation of China(42192553 and 71834003)the National Natural Science Foundation of China(72103217)+2 种基金the National Social Science Foundation of China(19BGL185)the Humanities and Social Sciences Planning Fund of the Ministry of Education(21YJA630088)and the Foundation of Clean Energy Branch of Huaneng International Power Jiangsu Energy Development Co.(HN-49A0-202100016-FWQT00015).
文摘Poverty-alleviation programs using solar energy(PAPSE)are poised to unlock unprecedented capital investments with significant potential to reconcile the energy–poverty–climate nexus.1 These programs are economically feasible because the costs of generating renewable energy have declined precipitously over the past decade;between 2010 and 2019,solar photovoltaiccosts decreased by 82%.Furthermore,the number of annual equivalent-use hours of sunlight in most countries exceeds 1200,meaning that PAPSE approaches are feasible in many places and can be undertaken independently from the power grid.
