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Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia 被引量:5
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作者 Jinsong Tang Yu Fan +15 位作者 Hong li Qun Xiang Deng-Feng Zhang zongchang li Ying He Yanhui liao Ya Wang Fan He Fengyu Zhang Yin Yao Shugart Chunyu liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang Yao Xiaogang Chen 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2017年第6期295-306,共12页
Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant ... Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24689 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size. 展开更多
关键词 Whole-genome sequencing SCHIZOPHRENIA Monozygotic twin De novo mutation Combined effect SUSCEPTIBILITY
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Reduced middle cingulate gyrus volume in late-onset schizophrenia in a Chinese Han population: a voxel-based structural MRI study 被引量:2
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作者 Hong li Jinsong Tang +7 位作者 liping Chen Yanhui liao Bing Zhou Ying He zongchang li Luxian Lv Yi Zeng Xiaogang Chen 《Neuroscience Bulletin》 SCIE CAS CSCD 2015年第5期626-627,共2页
Dear Editor:Numerous magnetic resonance imaging(MRI)studies have demonstrated that patients with early-onset schizophrenia(EOS)have widespread structural abnormalities in the cortical gray matter[1],suggesting th... Dear Editor:Numerous magnetic resonance imaging(MRI)studies have demonstrated that patients with early-onset schizophrenia(EOS)have widespread structural abnormalities in the cortical gray matter[1],suggesting that neurobiological processes play a central role in the structural abnormalities underlying the pathophysiology of schizophrenia[2].In addition,volumetric abnormalities have been used to identify individuals at risk of mental states of 展开更多
关键词 schizophrenia volumetric gyrus cortical widespread underlying topological illness corrected consent
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