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Recent progress in injectable bone repair materials research 被引量:1
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作者 zonggang chen Xiuli ZHANG +4 位作者 Lingzhi KANG Fei XU Zhaoling WANC Fu-Zhai CUI Zhongwu GUO 《Frontiers of Materials Science》 SCIE CSCD 2015年第4期332-345,共14页
Minimally invasive injectable self-setting materials are useful for bone repairs and for bone tissue regeneration in situ. Due to the potential advantages of these materials, such as causing minimal tissue injury, nea... Minimally invasive injectable self-setting materials are useful for bone repairs and for bone tissue regeneration in situ. Due to the potential advantages of these materials, such as causing minimal tissue injury, nearly no influence on blood supply, easy operation and negligible postoperative pain, they have shown great promises and successes in clinical applications. It has been proposed that an ideal injectable bone repair material should have features similar to that of natural bones, in terms of both the microstructure and the composition, so that it not only provides adequate stimulus to facilitate cell adhesion, proliferation and differentiation but also offers a satisfactory biological environment for new bone to grow at the implantation site. This article reviews the properties and applications of injectable bone repair materials, including those that are based on natural and synthetic polymers, calcium phosphate, calcium phosphate/ polymer composites and calcium sulfate, to orthopedics and bone tissue repairs, as well as the progress made in biomimetic fabrication of injectable bone repair materials. 展开更多
关键词 bone repair material POLYMER calcium phosphate calcium sulfate BIOMIMETIC
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Sequential One-Pot Three-Enzyme Synthesis of the Tetrasaccharide Repeating Unit of Group B Streptococcus Serotype Ⅷ Capsular Polysaccharide
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作者 Min Liang Wei Gong +5 位作者 Chongzhen Sun Jielin Zhao Hong Wang zonggang chen Min Xiao Guofeng Gu 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第9期1039-1044,共6页
The biochemical property and functional identification of three recombinant glycosyltransferases,includingβ-1,4-rhamnosyltransferase(Cps8R),β-1,4-galactosyltransferase(Cps8) and α-2,3-sialyltransferase(Cps8K)involv... The biochemical property and functional identification of three recombinant glycosyltransferases,includingβ-1,4-rhamnosyltransferase(Cps8R),β-1,4-galactosyltransferase(Cps8) and α-2,3-sialyltransferase(Cps8K)involved in the biosynthesis of the tetrasaccharide repeating unit of serotypeⅧcapsular polysaccharide(CPS)of Group B Streptococci(GBS),were systematically investigated.Subsequently,these recombinant enzymes were employed for one-pot three-enzyme efficient synthesis of the tetrasaccharide repeating unit of GBS serotypeⅧCPS using the chemically synthesized Glca-PP-(CH2)ir-OPh as the starting substrate in a satisfying yieldof 87%. 展开更多
关键词 Streptococcus agalactiae Capsular polysaccharide OLIGOSACCHARIDES Enzyme catalysis BIOSYNTHESIS
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