Correction:Cell Regen 12,13(2023).https://doi.org/10.1186/s13619-023-00157-8.Following publication of the original article(Ye et al.2023),the authors reported that the“Competing inter-ests”section needed to be updat...Correction:Cell Regen 12,13(2023).https://doi.org/10.1186/s13619-023-00157-8.Following publication of the original article(Ye et al.2023),the authors reported that the“Competing inter-ests”section needed to be updated.The original version was:The authors declare no competing interests.展开更多
Adipose tissues are essential for actively regulating systemic energy balance,glucose homeostasis,immune responses,reproduction,and longevity.Adipocytes maintain dynamic metabolic needs and possess heterogeneity in en...Adipose tissues are essential for actively regulating systemic energy balance,glucose homeostasis,immune responses,reproduction,and longevity.Adipocytes maintain dynamic metabolic needs and possess heterogeneity in energy storage and supply.Overexpansion of adipose tissue,especially the visceral type,is a high risk for diabetes and other metabolic diseases.Changes in adipocytes,hypertrophy or hyperplasia,contribute to the remodeling of obese adipose tissues,accompanied by abundant immune cell accumulation,decreased angiogenesis,and aberrant extracellular matrix deposition.The process and mechanism of adipogenesis are well known,however,adipose precursors and their fate decision are only being defined with recent information available to decipher how adipose tissues generate,maintain,and remodel.Here,we discuss the key findings that identify adipose precursors phenotypically,with special emphasis on the intrinsic and extrinsic signals in instructing and regulating the fate of adipose precursors under pathophysiological conditions.We hope that the information in this review lead to novel therapeutic strategies to combat obesity and related metabolic diseases.展开更多
文摘Correction:Cell Regen 12,13(2023).https://doi.org/10.1186/s13619-023-00157-8.Following publication of the original article(Ye et al.2023),the authors reported that the“Competing inter-ests”section needed to be updated.The original version was:The authors declare no competing interests.
基金supported by grants from the National Key R&D Program of China(2022YFA0807300,2018YFA0107500)the Scientific Innovation Project of the Chinese Academy of Sciences(XDA16020403)the National Natural Science Foundation of China(31961133024,32070872,81861138015,81930085 and 81571612).
文摘Adipose tissues are essential for actively regulating systemic energy balance,glucose homeostasis,immune responses,reproduction,and longevity.Adipocytes maintain dynamic metabolic needs and possess heterogeneity in energy storage and supply.Overexpansion of adipose tissue,especially the visceral type,is a high risk for diabetes and other metabolic diseases.Changes in adipocytes,hypertrophy or hyperplasia,contribute to the remodeling of obese adipose tissues,accompanied by abundant immune cell accumulation,decreased angiogenesis,and aberrant extracellular matrix deposition.The process and mechanism of adipogenesis are well known,however,adipose precursors and their fate decision are only being defined with recent information available to decipher how adipose tissues generate,maintain,and remodel.Here,we discuss the key findings that identify adipose precursors phenotypically,with special emphasis on the intrinsic and extrinsic signals in instructing and regulating the fate of adipose precursors under pathophysiological conditions.We hope that the information in this review lead to novel therapeutic strategies to combat obesity and related metabolic diseases.
