This study aimed to evaluate the satisfaction of village doctors to essential medicines list (EML) and accessibility of essential medicines (EMs) distribution to improve the implementation of EML in village clinics.A ...This study aimed to evaluate the satisfaction of village doctors to essential medicines list (EML) and accessibility of essential medicines (EMs) distribution to improve the implementation of EML in village clinics.A total of 422 village doctors from five counties in three provinces of China were surveyed by questionnaires.Logistic regression analysis was conducted to identify the main factors associated with village doctors' evaluation of EML.The results showed that village doctors had a negative evaluation in satisfaction level of EML to village-based care and accessibility of EM distribution.The government should adjust EML regularly based on the actual health status of local villagers in China and focus on adding appropriate drugs that meet the needs of villagers with chronic disease.The local government should also attach importance to the distribution of EMs and maintain their supply in village clinics.展开更多
Objective： To explore the relationships of the polymorphisms of xeroderma pigmentosum C （XPC） and the susceptibility of esophageal cancer （EC） in Changzhi area, China. Methods： The study was conducted by a case...Objective： To explore the relationships of the polymorphisms of xeroderma pigmentosum C （XPC） and the susceptibility of esophageal cancer （EC） in Changzhi area, China. Methods： The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism （PCR-RFLP）. Results： The frequencies of wild homozygote （PAT-/-）, mutation heterozygote （PAT-/＋） and mutation homozygote （PAT＋/＋） of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups （X^2 =0.332, P=0.847）. There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A （XPA） （S=0.85） and pickled food （S=0.81）. Conclusion： A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.展开更多
1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symp...1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].展开更多
Background Maternal smoking during pregnancy may be associated with low birth weight(LBW)in offspring and global risk estimates have not been summarized previously.We aimed to systematically explore evidence regarding...Background Maternal smoking during pregnancy may be associated with low birth weight(LBW)in offspring and global risk estimates have not been summarized previously.We aimed to systematically explore evidence regarding maternal smoking and the LBW risk in offspring globally and examine possible causes of heterogeneity across relevant studies.Methods Comprehensive search of PubMed,Ovid Embase,Ovid Medline(R),and Web of science from inception until October 2021 was carried out.A random-effects meta-analysis was used to estimate the pooled odds ratio(OR)and corresponding 95%confidence interval(CI).Restricted cubic spline analysis with three knots was used to further examine the dose-response relationship.Results Literature searches yielded 4940 articles,of which 53 met inclusion criteria(comprising 55 independent studies).Maternal smoking during pregnancy was significantly associated with the risk of LBW in offspring(OR=1.89,95%CI=1.80-1.98).Furthermore,an obvious dose-response relationship between the amount of cigarettes daily smoked in pregnancy and the risk of LBW in offspring was observed.The results of subgroup analyses indicated that the risk of maternal smoking on LBW was larger in more recently conducted studies(P=0.020)and longer period of active smoking during pregnancy(P=0.002).No evidence of publication bias was found.Conclusions In summary,maternal smoking in pregnancy was significantly associated with a higher risk of LBW in offspring on a global scale.The risk of maternal smoking on infant LBW seems to be increasing over time,and was higher with longer smoking duration throughout pregnancy and more cigarettes smoked daily.展开更多
文摘This study aimed to evaluate the satisfaction of village doctors to essential medicines list (EML) and accessibility of essential medicines (EMs) distribution to improve the implementation of EML in village clinics.A total of 422 village doctors from five counties in three provinces of China were surveyed by questionnaires.Logistic regression analysis was conducted to identify the main factors associated with village doctors' evaluation of EML.The results showed that village doctors had a negative evaluation in satisfaction level of EML to village-based care and accessibility of EM distribution.The government should adjust EML regularly based on the actual health status of local villagers in China and focus on adding appropriate drugs that meet the needs of villagers with chronic disease.The local government should also attach importance to the distribution of EMs and maintain their supply in village clinics.
基金supported by a grant from Scholarship Council Fund of Shanxi Province (No.200565)
文摘Objective： To explore the relationships of the polymorphisms of xeroderma pigmentosum C （XPC） and the susceptibility of esophageal cancer （EC） in Changzhi area, China. Methods： The study was conducted by a case-control study which included 196 cases of EC and 201 cases of controls. XPC PAT polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism （PCR-RFLP）. Results： The frequencies of wild homozygote （PAT-/-）, mutation heterozygote （PAT-/＋） and mutation homozygote （PAT＋/＋） of XPC were 36.73%, 51.53% and 11.74% in case group, 37.81%, 52.24% and 9.95% in control group, respectively, and there was no significant difference between the two groups （X^2 =0.332, P=0.847）. There was no interaction between XPC PAT mutation genotype and xeroderma pigmentosum A （XPA） （S=0.85） and pickled food （S=0.81）. Conclusion： A genetic polymorphism in XPC may be not associated with esophageal cancer in Changzhi population.
基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2019-I2M-5-023)Hainan Provincial Science and Technology Major Project(No.ZDKJ201804)+2 种基金National Natural Science Foundation of China(No.81871611)National Natural Science Foundation of China(No.81760352)Project of Hainan Provincial Department of Education(No.Hnjg2019ZD-16)
文摘1.Introduction Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac causes.It is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].
基金This study was funded by the by the National Social Science Foundation of China(Grant No.18ZDA085).
文摘Background Maternal smoking during pregnancy may be associated with low birth weight(LBW)in offspring and global risk estimates have not been summarized previously.We aimed to systematically explore evidence regarding maternal smoking and the LBW risk in offspring globally and examine possible causes of heterogeneity across relevant studies.Methods Comprehensive search of PubMed,Ovid Embase,Ovid Medline(R),and Web of science from inception until October 2021 was carried out.A random-effects meta-analysis was used to estimate the pooled odds ratio(OR)and corresponding 95%confidence interval(CI).Restricted cubic spline analysis with three knots was used to further examine the dose-response relationship.Results Literature searches yielded 4940 articles,of which 53 met inclusion criteria(comprising 55 independent studies).Maternal smoking during pregnancy was significantly associated with the risk of LBW in offspring(OR=1.89,95%CI=1.80-1.98).Furthermore,an obvious dose-response relationship between the amount of cigarettes daily smoked in pregnancy and the risk of LBW in offspring was observed.The results of subgroup analyses indicated that the risk of maternal smoking on LBW was larger in more recently conducted studies(P=0.020)and longer period of active smoking during pregnancy(P=0.002).No evidence of publication bias was found.Conclusions In summary,maternal smoking in pregnancy was significantly associated with a higher risk of LBW in offspring on a global scale.The risk of maternal smoking on infant LBW seems to be increasing over time,and was higher with longer smoking duration throughout pregnancy and more cigarettes smoked daily.
