To the Editor:Hepatocellular carcinoma(HCC)is the second most common cause of cancer-related death worldwide[1].Repeated liver resection remains a valid and safe curative therapy option for recurrent HCC in a minority...To the Editor:Hepatocellular carcinoma(HCC)is the second most common cause of cancer-related death worldwide[1].Repeated liver resection remains a valid and safe curative therapy option for recurrent HCC in a minority of patients,because of multifocal intrahepatic or extra-hepatic recurrence and tumors in unresectable locations[2].HCC nodules less than 3 cm located in the hepatic dome beneath the diaphragm may represent one of the most difficult sites for resection[3].Therefore,some local invasive therapies,such as radiofrequency ablation(RFA),microwave ablation,transarterial chemoembolization(TACE)and laser hyperthermia,have been developed and applied in clinical HCC treatment[4].RFA has high frequency energy which heats the surrounding tissues and causes severe complications such as acute massive hemorrhage,thermal injury to viscera,pneumothorax and cardiac tamponade[5].展开更多
Dear Editor,A large number of COVID-19 patients experience body-specific conditions such as fatigue,sleep disturbances,anxiety,depression,and dyspnea after the disease has subsided,which is called“long COVID-19”.1 S...Dear Editor,A large number of COVID-19 patients experience body-specific conditions such as fatigue,sleep disturbances,anxiety,depression,and dyspnea after the disease has subsided,which is called“long COVID-19”.1 Studies have confirmed reduced microbial diversity,enrichment of opportunistic pathogens and depletion of beneficial symbiotic bacteria in patients with COVID-19.2,3 Long-term dysregulation of the microbiota has also been observed in recovered patients.4 Nevertheless,long-term fungal microbiota follow-up was still blank.展开更多
Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic ...Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.展开更多
基金supported by grants from National S&T Major Project of China(2018ZX10301201-008)National Natural Science Foundation of China(81600506,81702757,81702346 and 81702927)
文摘To the Editor:Hepatocellular carcinoma(HCC)is the second most common cause of cancer-related death worldwide[1].Repeated liver resection remains a valid and safe curative therapy option for recurrent HCC in a minority of patients,because of multifocal intrahepatic or extra-hepatic recurrence and tumors in unresectable locations[2].HCC nodules less than 3 cm located in the hepatic dome beneath the diaphragm may represent one of the most difficult sites for resection[3].Therefore,some local invasive therapies,such as radiofrequency ablation(RFA),microwave ablation,transarterial chemoembolization(TACE)and laser hyperthermia,have been developed and applied in clinical HCC treatment[4].RFA has high frequency energy which heats the surrounding tissues and causes severe complications such as acute massive hemorrhage,thermal injury to viscera,pneumothorax and cardiac tamponade[5].
基金sponsored by grants from the Henan Province Epidemic Prevention and Control Emergency Scientific Research Project (221111311700 and 221111311600)National Key Research and Development Program of China (2022YFC2303100)+1 种基金Research Project of Jinan Microecological Biomedicine Shandong Laboratory (JNL-2022001A and JNL-2022015B)Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (QNCXTD2023002).
文摘Dear Editor,A large number of COVID-19 patients experience body-specific conditions such as fatigue,sleep disturbances,anxiety,depression,and dyspnea after the disease has subsided,which is called“long COVID-19”.1 Studies have confirmed reduced microbial diversity,enrichment of opportunistic pathogens and depletion of beneficial symbiotic bacteria in patients with COVID-19.2,3 Long-term dysregulation of the microbiota has also been observed in recovered patients.4 Nevertheless,long-term fungal microbiota follow-up was still blank.
基金This work was supported by the American Heart Association(Nos.18TPA34230092 and 19EIA34660286 to K.C.)the National Natural Science Foundation of China(No.U1904149 to H.X.L.)+1 种基金National S&T Major Project of China(No.2018ZX10301201-008 to Z.G.R.)the High Technology Research and Development Program of Henan Province(No.20A320055 to H.X.L.).
文摘Liver fibrosis, resulting from chronic liver damage and characterized by the accumulation of extracellular matrix (ECM) proteins, is a characteristic of most types of chronic liver diseases. The activation of hepatic stellate cells (HSC) is considered an essential pathological hallmark in liver fibrosis. Although nitric oxide (NO) can effectively induce HSC apoptosis, the systemic administration of NO is ineffective and may cause severe complications such as hypotension. To overcome this limitation, nanoparticles were designed to target HSCs and release NO locally under the exposure of near infrared light (NIR). To achieve this, upconversion nanoparticle (UCNP) cores were enveloped in mesoporous silica shells (UCNP@mSiO2), which were modified with hyaluronic acid (HA-UCNP@mSiO2) and Roussin’s black salt (RBS). HA molecules recognize and bind to CD44 proteins, which are overexpressed on activated HSCs. Under exposure to a 980-nm NIR laser, the UCNP cores convert the 980-nm wavelength into ultraviolet (UV) light, which then energizes the RBS (NO donors), resulting in an efficient release of NO inside of the HSCs. Once released, NO triggers HSC apoptosis and reverses the liver fibrosis. This targeted and controlled release method provides the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis.
