Preparation and release of curcumin/silk fibroin/sodium alginate film

The aim of this study was to prepare silk fibroin/sodium alginate composite film containing curcumin by casting method.Orthogonal test was used to optimize the formulation according to the values of tensile strength and elongation at break.The release of curcumin in the optimal film was studied in order to explore its application as wound dressing.The results showed that the optimum composition of curcumin/silk fibroin/sodium alginate composite film was as follows:Silk fibroin(70 mg/mL)2.7 g,sodium alginate(24 mg/mL)0.84 g,span 40(5.0 mg/mL)0.4 g,glycerol(3.75%,V/V)3 mL,curcumin(0.2 mg/mL)0.016 g.The optimum film showed the tensile strength and the elongation at break was(0.628±0.032)MPa and(0.794±0.046)%,respectively.

Pharmacological effects and mechanisms of polyphenols in Radix Puerariae on liver protection and anti-diabetes

In recent years,the incidence of liver diseases and diabetes is increasing year by year,and the patients are younger than before.Although the clinical medicine treatment is eff ective,but it would produce side eff ects.Radix Puerariae is the dried root of the Pueraria lobata(Willd.)Ohwi.Puerarin is an isofl avone compound with polyphenol structure.It is one of the main bioactive components of Radix Puerariae.Studies have found that the application of puerarin off ers beatifical act on liver protection,hypoglycemia,blood lipid,antioxidant,anti-osteoporosis,anti-cancer,anti-inflammatory and cardiovascular protection.Puerarin has been used in the treatment of liver disease and diabetes.In this study,the eff ect of puerarin on liver protection,diabetes treatment and the relationship between the two diseases were reviewed.The therapeutic mechanism and molecular targets of puerarin were explored in order to further improve the development of puerarin and increase its clinical application in protection against liver disease and diabetes.