Hyperactive androgen receptor （AR） activity remains a key determinant of the onset and progression of prostate cancer and resistance to current therapies. The mechanisms governing castrate resistant prostate cancer ...Hyperactive androgen receptor （AR） activity remains a key determinant of the onset and progression of prostate cancer and resistance to current therapies. The mechanisms governing castrate resistant prostate cancer are poorly understood, but defining these molecular events is essential in order to impact deaths from prostate cancer.展开更多
Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological conditions.However,the mechanisms underlying T_(reg)homeostasis remain incompletely underst...Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological conditions.However,the mechanisms underlying T_(reg)homeostasis remain incompletely understood.Here,we report that RIPK1 is crucial for T_(reg) cell survival and homeostasis.We generated mice with T_(reg) cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death.Unlike conventional T cells,Treg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent apoptosis.However,simultaneous removal of both Fadd and Ripk3 completely restored the homeostasis of Ripk1-deficient Treg cells by blocking two cell death pathways.Thus,our study highlights the critical role of RIPK1 in regulating Treg cell homeostasis by controlling both apoptosis and necroptosis,thereby providing novel insights into the mechanisms of Treg cell homeostasis.展开更多
Dear Editor,Coronavirus disease 2019(covid-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has led to 460 million cases confirmed and 6.1 million deaths across almost 200 countries until Marc...Dear Editor,Coronavirus disease 2019(covid-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has led to 460 million cases confirmed and 6.1 million deaths across almost 200 countries until March 2022.In addition to the vaccine-based protection against viral infection,it is urgently needed to accurately diagnose covid-19 patients as early as possible after infection.展开更多
文摘Hyperactive androgen receptor （AR） activity remains a key determinant of the onset and progression of prostate cancer and resistance to current therapies. The mechanisms governing castrate resistant prostate cancer are poorly understood, but defining these molecular events is essential in order to impact deaths from prostate cancer.
基金supported by the following grants:National Key Research and Development Program of China(2021YFA1301402)Shanghai Municipal Science and Technology Major Project(ZD2021CY001)+4 种基金National Key Research and Development Program of China(2021YFE0200900,2022YFA0807300)National Natural Science Foundation of China(82101833,82073901)Three-year Action Plan for Shanghai TCM Development and Inheritance Program[ZY(2021-2023)-0103]Top-level Clinical Discipline Project of Shanghai Pudong District(grant/award number:PWYgf 2021-01)Training Plan for Discipline Leaders of Shanghai Pudong New Area Health Commission(grant/award number:PWRd2020-09).
文摘Regulatory T(T_(reg))cells play an essential role in maintaining immune balance across various physiological and pathological conditions.However,the mechanisms underlying T_(reg)homeostasis remain incompletely understood.Here,we report that RIPK1 is crucial for T_(reg) cell survival and homeostasis.We generated mice with T_(reg) cell-specific ablation of Ripk1 and found that these mice developed fatal systemic autoimmunity due to a dramatic reduction in the Treg cell compartment caused by excessive cell death.Unlike conventional T cells,Treg cells with Ripk1 deficiency were only partially rescued from cell death by blocking FADD-dependent apoptosis.However,simultaneous removal of both Fadd and Ripk3 completely restored the homeostasis of Ripk1-deficient Treg cells by blocking two cell death pathways.Thus,our study highlights the critical role of RIPK1 in regulating Treg cell homeostasis by controlling both apoptosis and necroptosis,thereby providing novel insights into the mechanisms of Treg cell homeostasis.
基金grants 81772810 and 81972476 from the National Natural Science Foundation of Chinagrants 18411965900 and 20JC1410400 from the Science and Technology Commission of Shanghai Municipality+2 种基金grant PKJ2020-Y30 from the Shanghai Pudong Technology and Economic Commissiongrant PDZY-2018-0603 from Pudong New Area Clinical Traditional Chinese medicine of top Discipline development programGrant PWRd2019-04 for Pudong New Area leader of Discipline.
文摘Dear Editor,Coronavirus disease 2019(covid-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has led to 460 million cases confirmed and 6.1 million deaths across almost 200 countries until March 2022.In addition to the vaccine-based protection against viral infection,it is urgently needed to accurately diagnose covid-19 patients as early as possible after infection.
