In the latest issue of Nature,Zhang et al.characterized a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural b...In the latest issue of Nature,Zhang et al.characterized a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural biology,cell biology,and bioinformatics analyses.1 In this commentary,we highlight their key findings and provide our insights into the research paradigm for further exploration of a novel transcriptional regulation mode as well as a therapeutic strategy from the structural aspects of the FOXP3 complex(Figure 1).展开更多
Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue r...Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue repair.CBX4 has been shown to have diverse,even opposite functions in different types of tissue and malignancy in previous studies.展开更多
In the new issue of Cell,Dr.Meisel’s teamcharacterized how the orally administrated probiotic bacteria Lactobacillus reuteri(Lr)translocated from the gut to tumors in mice with melanoma.1 Furthermore,its production o...In the new issue of Cell,Dr.Meisel’s teamcharacterized how the orally administrated probiotic bacteria Lactobacillus reuteri(Lr)translocated from the gut to tumors in mice with melanoma.1 Furthermore,its production of a compound called indole-3-aldehyde(I3A)derived fromdietary tryptophan directly stimulates immune cells to make cancer immunotherapy more effective(Figure 1A).展开更多
基金National Key R&D Program of China(2022YFA1106400 to Z.W.and Y.L.and 2020YFA0803201 to Z.W.)National Natural Science Foundation of China(32270886 and 32070827 to Z.W.,82273235 and 82003012 to Y.L.,and 32171216 to H.Y.)STI2030-Major Projects(2022ZD0212600 to H.Y.).
文摘In the latest issue of Nature,Zhang et al.characterized a novel ladder-like structure of FOXP3-DNA interaction involving FOXP3 multimerization and remote DNA bridging through a combination of biochemistry,structural biology,cell biology,and bioinformatics analyses.1 In this commentary,we highlight their key findings and provide our insights into the research paradigm for further exploration of a novel transcriptional regulation mode as well as a therapeutic strategy from the structural aspects of the FOXP3 complex(Figure 1).
基金The authors thank Dr.Kwok-Kin Wong for kindly providing the KrasG12D mice.This work was supported by the National Key R&D Program of China(2022YFA1106400 and 2020YFA0803201 to Z.W.)The National Natural Science Foundation of China(32270886 and 32070827 to Z.W.,31971111 to C.L,31900811 to W.Y.)+1 种基金The Natural Science Foundation of Guangdong Province of China(2021A1515010674 to W.Y.)Key laboratory tasks(LG202103-01-07 to Z.W.).
文摘Chromobox protein homolog 4(CBX4)is a component of the Polycomb group(PcG)multiprotein Polycomb repressive complexes 1(PRC1),which is participated in several processes including growth,senescence,immunity,and tissue repair.CBX4 has been shown to have diverse,even opposite functions in different types of tissue and malignancy in previous studies.
基金the financial support for this research received fromthe Health and Medical Research Fund of Hong Kong(10212276)National Natural Science Foundation of China(Nos.32071301,32111530179,32270886,and 32070827)+5 种基金National Key R&D Program of China(2022YFA1106400 and 2020YFA0803201)Key laboratory tasks(LG202103-01-07)Youth Innovation Promotion Association of CAS(2021264)Shanghai Natural Science Foundation(22ZR1469800)Outstanding Youth Reserve Talent Project(IDF201370/074)Scientific Research Foundation for the introduction of talent(JIF201035Y).
文摘In the new issue of Cell,Dr.Meisel’s teamcharacterized how the orally administrated probiotic bacteria Lactobacillus reuteri(Lr)translocated from the gut to tumors in mice with melanoma.1 Furthermore,its production of a compound called indole-3-aldehyde(I3A)derived fromdietary tryptophan directly stimulates immune cells to make cancer immunotherapy more effective(Figure 1A).
