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Role of monocytes and macrophages in experimental and human acute liver failure 被引量:13
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作者 Lucia A Possamai Charalambos Gustav Antoniades +4 位作者 Quentin M Anstee alberto quaglia Diego Vergani Mark Thursz Julia Wendon 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第15期1811-1819,共9页
Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the... Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the pathogenesis of ALF is activation of the immune system with mobilisation of cellular effectors and massive production of cytokines. As key components of the innate immune system, monocytes and macrophages are postulated to play a central role in the initiation, progression and resolution of ALF. ALF in humans follows a rapidly progressive clinical course that poses inherent difficulties in delineating the role of these pivotal immune cells. Therefore, a number of experimental models have been used to study the pathogenesis of ALF. Here we consider the evidence from experimental and human studies of ALF on the role of monocytes and macrophages in acute hepatic injury and the ensuing extrahepatic manifestations, including functional monocyte deactivation and multiple organ failure. 展开更多
关键词 MONOCYTE Macrophage Acute liver failure Inflammation Monocyte chemoattractant protein-1/ chemokine (C-C motif) receptor-2 CYTOKINE
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Congenital extrahepatic portosystemic shunt complicated by the development of hepatocellular carcinoma 被引量:7
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作者 Ruchi Sharma Abid Suddle +3 位作者 alberto quaglia Praveen Peddu John Karani Thomas Satyadas 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2015年第5期552-557,共6页
Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a ... Congenital extrahepatic portosystemic shunt,also known as Abernethy malformation, is a rare congenital malformation. It causes shunting of blood through a communication between the portal and systemic veins such as a patent ductus venous. We report 3 cases of Abernethy malformation complicated by the development of hepatocellular carcinoma. Additionally, we comprehensively reviewed all previously reported cases and highlighted common features that may help in early diagnosis and appropriate management.Patients with Abernethy malformation may have an increased propensity to develop hepatocellular carcinoma. All 5 previously reported cases, plus the three of our patients, have a type 1(complete) shunt suggesting a role for absent portal blood flow in the pathogenesis of hepatocellular carcinoma. Congenital extrahepatic portosystemic shunt should be sought for in cases with raised serum ammonia, hepatic encephalopathy or hepatocellular carcinoma in the absence of cirrhosis. 展开更多
关键词 Abernethy malformation congenital extrahepatic portosystemic shunt congenital absence of portal vein patent ductus venosus hepatocellular carcinoma
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Liver resection for the treatment of a congenital intrahepatic portosystemic venous shunt 被引量:2
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作者 michail papamichail amir ali +2 位作者 alberto quaglia john karani nigel heaton 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2016年第3期329-333,共5页
Intrahepatic portosystemic shtmts (IPSS) are rare congenital anomalies arising from disordered portal vein em- bryogenesis. It has been described in both children and adults and may be asymptomatic or be associated ... Intrahepatic portosystemic shtmts (IPSS) are rare congenital anomalies arising from disordered portal vein em- bryogenesis. It has been described in both children and adults and may be asymptomatic or be associated with a variety of neurophysiological and pulmonary complications. When rec- ognized, early intervention to occlude the shunt will reverse the associated complications. Literature review reports of surgical and radiological occlusion of the shunt, but due to its rarity, a standard therapeutic protocol has not been established. A case of a 38-year-old woman with abdominal pain and low grade encephalopathy, diagnosed with an IPSS and treated by right hepatectomy was reported. 展开更多
关键词 intrahepatic portosystemic shunt liver resection
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Pigmented well-differentiated hepatocellular neoplasm with β-catenin mutation 被引量:1
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作者 Lara Neves Souza Rodrigo Bronze de Martino +3 位作者 Richard Thompson Sandra Strautnieks Nigel D Heaton alberto quaglia 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2015年第6期660-664,共5页
ABSTRACT: According to the most recent WHO classification of hepatocellular adenomas, a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of... ABSTRACT: According to the most recent WHO classification of hepatocellular adenomas, a small percentage of inflammatory hepatocellular adenomas presents with mutation in the β-catenin gene and are at higher risk of malignant transformation. It has been recognized that adenoma-like hepatocellular neoplasms with focal atypia, or in unusual clinical context present with similar cytogenetic and immunohistochemistry characteristics to well-differentiated hepatocellular carcino- mas. 展开更多
关键词 hepatocellular adenoma hepatocellular carcinoma Β-CATENIN glutamine synthetase DIETHYLSTILBESTROL
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