目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的...目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的健康志愿者(对照组),均行心脏MRI扫描。HCM组按有无心肌延迟强化(late gadolinium enhancement,LGE)分为LGE(+)组和LGE(-)组。采用基于DRA算法的TrufiStrain软件进行心肌形变分析,测量整体径向应变峰值(global peak radial strain, GPRS)、整体环向应变峰值(global peak circumferential strain, GPCS)和整体纵向应变峰值(global peak longitudinal strain, GPLS)以及心尖部、中部和基底部的径向应变峰值(peak radial strain, PRS)、环向应变峰值(peak circumferential strain, PCS)和纵向应变峰值(peak longitudinal strain,PLS),探讨心肌形变参数在HCM中的诊断效能及其与心室壁厚度、LGE间的关系。结果:除心尖部PCS外,HCM组的GPRS、GPCS、GPLS及基底部和中部PRS、PCS、PLS,以及心尖部的PRS、PLS均明显低于对照组(P<0.05),而HCM组的整体及各部分3个方向(环向、纵向、径向)的应变率比值均明显小于对照组(P<0.05),且LGE(-)组及对照组各部分的PRS、PCS、PLS及3个方向的舒张早期和晚期应变率比值[径向应变率比值(ratio of radial strain rate during early and late diastole,REL),环向应变率比值(ratio of circumferential strain rate during early and late diastole,CEL)和纵向应变率比值(ratio of longitudinal strain rate during early and late diastole,LEL)]均大于LGE(+)组(P<0.05)。GPRS、GPCS、GPLS、REL、CEL、LEL均与左心室心肌最大厚度明显相关(P<0.05)。GPRS、GPCS、GPLS、REL、CEL及LEL诊断HCM的曲线下面积分别为0.686、0.905、0.921、0.972、0.974及0.917,GPRS、GPCS、GPLS、REL、CEL及LEL预测HCM患者是否有LGE的曲线下面积均大于0.871。结论:基于DRA的心肌形变分析在诊断HCM、预测HCM患者发生LGE中具有重要价值,且与心肌厚度密切相关。展开更多
在食品工业中,不同粒度的膳食纤维会直接影响产品品质。研究不同粒度膳食纤维的理化性质及功能活性,可使其得到更广泛的应用。本研究通过70%乙醇去除百香果皮中的色素,粉碎后得到百香果皮纤维粉(Passion fruit peel residue,PFPR)。研...在食品工业中,不同粒度的膳食纤维会直接影响产品品质。研究不同粒度膳食纤维的理化性质及功能活性,可使其得到更广泛的应用。本研究通过70%乙醇去除百香果皮中的色素,粉碎后得到百香果皮纤维粉(Passion fruit peel residue,PFPR)。研究粒径范围为217.00~20.23μm的6种PFPR的理化性质及功能活性。结果表明,随着粒径的减小,PFPR粉体堆积密度、振实密度、膨胀力、持水力、持油力、结合水力、阳离子交换能力及粘度先增加后降低,而休止角则逐步增加。粒径为145.67μm粉体在透析时间为30 min时,延迟效果最好,此时葡萄糖透析延迟值为30.55%。抗氧化实验结果显示,粒径为20.23μm粉体,浓度为80 mg/mL时,对DPPH·(60.28%)和ABTS^(+)·(23.04%)清除效果最好,PFPR中多酚的释放量与其抗氧化效果存在着明显的相关性。研究为PFPR在食品工业中的应用提供一定的参考。展开更多
Ecological restoration by Taman＇x plants on semi-arid saline lands affects the accumulation, distribution patterns and related mechanisms of soil water content and salinity. In this study, spatio-temporal variations ...Ecological restoration by Taman＇x plants on semi-arid saline lands affects the accumulation, distribution patterns and related mechanisms of soil water content and salinity. In this study, spatio-temporal variations of soil water content and salinity around natural individual Tamarix ramosissiraa Ledeb. were invetigated in a semi-arid saline region of the upper Yellow River, Northwest China. Specifically, soil water content, electrical conductivity （EC）, sodium adsorption ratio （SARa）, and salt ions （including Na＋, K＋, Ca2＋, Mg2＋ and 8042-） were measured at different soil depths and at different distances from the trunk of T. ramasissima in May, July, and September 2016. The soil water content at the 20-80 cm depth was significantly lower in July and September than in May, indicating that T. ramosissima plants absorb a large amount of water through the roots during the growing period, leading to the decreasing of soil water content in the deep soil layer. At the 0-20 cm depth, there was a salt island effect around individual T. ramosissima, and the ECe differed significantly inside and outside the canopy of T. ramosissima in May and July. Salt bioaccumulation and stemflow were two major contributing factors to this difference. The SAR at the 0-20 cm depth was significantly different inside and outside the canopy of T. ramosissima in the three sampling months. The values of SAR~ at the 60-80 cm depth in May and July were significantly higher than those at the 0-60 cm depth and higher than that at the corresponding depth in September. The distribution of Na＋ in the soil was similar to that of the SAI, while the concentrations of K＋, Ca2＋, and Mg2＋ showed significant differences among the sampling months and soil depths. Both season and soil depth had highly significant effects on soil water content, ECe and SARa, whereas distance from the trunk of T. ramosissima only significantly affected ECe. Based on these results, we recommend co-planting of shallow-rooted salt-tolerant species near the Tamarx plants and avoiding planting herbaceous plants inside the canopy of T. ramodssima for afforestation in this semi-arid saline region. The results of this study may provide a reference for appropriate restoration in the semi-arid saline regions of the upper Yellow River.展开更多
IgT(Immunoglobulin T)作为新型免疫球蛋白在粘膜免疫中具有重要作用.文中根据尼罗罗非鱼IgT基因序列构建原核表达载体获得IgT重组蛋白,相对分子量约75 k Da,并制备出效价较高的小鼠抗罗非鱼IgT的多克隆抗体.荧光定量PCR检测证明:健康...IgT(Immunoglobulin T)作为新型免疫球蛋白在粘膜免疫中具有重要作用.文中根据尼罗罗非鱼IgT基因序列构建原核表达载体获得IgT重组蛋白,相对分子量约75 k Da,并制备出效价较高的小鼠抗罗非鱼IgT的多克隆抗体.荧光定量PCR检测证明:健康尼罗罗非鱼中IgT在多种组织中都有表达,其中脾脏、皮肤、肠和鳃中表达量相对较高.无乳链球菌感染后,皮肤和头肾中IgT mRNA的相对表达量分别在12 h和4 d显著上调.免疫组化结果显示:IgT蛋白在头肾和皮肤中均有少量分布,在无乳链球菌刺激后,在皮肤中出现大量分布.以上结果表明:IgT在尼罗罗非鱼皮肤粘膜免疫中具有重要作用.展开更多
文摘目的:探讨基于可变形图像配准(deformableregistration algorithms,DRA)算法的心肌形变分析在肥厚型心肌病(hypertrophic cardiomyopathy,HCM)中的诊断及预后预测价值。方法:回顾性收集本院确诊的HCM患者23例,另招募23名年龄性别匹配的健康志愿者(对照组),均行心脏MRI扫描。HCM组按有无心肌延迟强化(late gadolinium enhancement,LGE)分为LGE(+)组和LGE(-)组。采用基于DRA算法的TrufiStrain软件进行心肌形变分析,测量整体径向应变峰值(global peak radial strain, GPRS)、整体环向应变峰值(global peak circumferential strain, GPCS)和整体纵向应变峰值(global peak longitudinal strain, GPLS)以及心尖部、中部和基底部的径向应变峰值(peak radial strain, PRS)、环向应变峰值(peak circumferential strain, PCS)和纵向应变峰值(peak longitudinal strain,PLS),探讨心肌形变参数在HCM中的诊断效能及其与心室壁厚度、LGE间的关系。结果:除心尖部PCS外,HCM组的GPRS、GPCS、GPLS及基底部和中部PRS、PCS、PLS,以及心尖部的PRS、PLS均明显低于对照组(P<0.05),而HCM组的整体及各部分3个方向(环向、纵向、径向)的应变率比值均明显小于对照组(P<0.05),且LGE(-)组及对照组各部分的PRS、PCS、PLS及3个方向的舒张早期和晚期应变率比值[径向应变率比值(ratio of radial strain rate during early and late diastole,REL),环向应变率比值(ratio of circumferential strain rate during early and late diastole,CEL)和纵向应变率比值(ratio of longitudinal strain rate during early and late diastole,LEL)]均大于LGE(+)组(P<0.05)。GPRS、GPCS、GPLS、REL、CEL、LEL均与左心室心肌最大厚度明显相关(P<0.05)。GPRS、GPCS、GPLS、REL、CEL及LEL诊断HCM的曲线下面积分别为0.686、0.905、0.921、0.972、0.974及0.917,GPRS、GPCS、GPLS、REL、CEL及LEL预测HCM患者是否有LGE的曲线下面积均大于0.871。结论:基于DRA的心肌形变分析在诊断HCM、预测HCM患者发生LGE中具有重要价值,且与心肌厚度密切相关。
基金funded by the Fundamental Research Funds for the Central Universities (2016ZCQ06)the Forestry Industry Research Special Funds for Public Welfare Projects (201504402)the Application Technology of Seaweed Fertilizer Based on Desertification Control and Saline-alkili Soil Improvement (2016HXFWSBXY002)
文摘Ecological restoration by Taman＇x plants on semi-arid saline lands affects the accumulation, distribution patterns and related mechanisms of soil water content and salinity. In this study, spatio-temporal variations of soil water content and salinity around natural individual Tamarix ramosissiraa Ledeb. were invetigated in a semi-arid saline region of the upper Yellow River, Northwest China. Specifically, soil water content, electrical conductivity （EC）, sodium adsorption ratio （SARa）, and salt ions （including Na＋, K＋, Ca2＋, Mg2＋ and 8042-） were measured at different soil depths and at different distances from the trunk of T. ramasissima in May, July, and September 2016. The soil water content at the 20-80 cm depth was significantly lower in July and September than in May, indicating that T. ramosissima plants absorb a large amount of water through the roots during the growing period, leading to the decreasing of soil water content in the deep soil layer. At the 0-20 cm depth, there was a salt island effect around individual T. ramosissima, and the ECe differed significantly inside and outside the canopy of T. ramosissima in May and July. Salt bioaccumulation and stemflow were two major contributing factors to this difference. The SAR at the 0-20 cm depth was significantly different inside and outside the canopy of T. ramosissima in the three sampling months. The values of SAR~ at the 60-80 cm depth in May and July were significantly higher than those at the 0-60 cm depth and higher than that at the corresponding depth in September. The distribution of Na＋ in the soil was similar to that of the SAI, while the concentrations of K＋, Ca2＋, and Mg2＋ showed significant differences among the sampling months and soil depths. Both season and soil depth had highly significant effects on soil water content, ECe and SARa, whereas distance from the trunk of T. ramosissima only significantly affected ECe. Based on these results, we recommend co-planting of shallow-rooted salt-tolerant species near the Tamarx plants and avoiding planting herbaceous plants inside the canopy of T. ramodssima for afforestation in this semi-arid saline region. The results of this study may provide a reference for appropriate restoration in the semi-arid saline regions of the upper Yellow River.
