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A neural m^(6)A pathway regulates behavioral aggregation in migratory locusts
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作者 Xianliang Huang Qing Li +11 位作者 Yanan Xu Ang Li Shanzheng Wang Yusheng Chen Chunrui Zhang Xia Zhang Hailin Wang cong lv Baofa Sun Shaoqin Li Le Kang Bing Chen 《Science China(Life Sciences)》 SCIE CAS CSCD 2024年第6期1242-1254,共13页
RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain unexplored.Here,we conducted a comprehensive molec... RNA N6-methyladenosine(m^(6)A),as the most abundant modification of messenger RNA,can modulate insect behaviors,but its specific roles in aggregation behaviors remain unexplored.Here,we conducted a comprehensive molecular and physiological characterization of the individual components of the methyltransferase and demethylase in the migratory locust Locusta migratoria.Our results demonstrated that METTL3,METTL14 and ALKBH5 were dominantly expressed in the brain and exhibited remarkable responses to crowding or isolation.The individual knockdown of methyltransferases(i.e.,METTL3 and METTL14)promoted locust movement and conspecific attraction,whereas ALKBH5 knockdown induced a behavioral shift toward the solitary phase.Furthermore,global transcriptome profiles revealed that m^(6)A modification could regulate the orchestration of gene expression to fine tune the behavioral aggregation of locusts.In summary,our in vivo characterization of the m^(6)A functions in migratory locusts clearly demonstrated the crucial roles of the m^(6)A pathway in effectively modulating aggregation behaviors. 展开更多
关键词 RNA methylation N^(6)-methyladenosine transcriptional orchestration aggregation behavior Locusta migratoria
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From amides to urea derivatives or carbamates with chemospecific C–C bond cleavage at room temperature
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作者 cong lv Dan Liu +3 位作者 Tegshi Muschin Chaolumen Bai Agula Bao Yong-Sheng Bao 《Organic Chemistry Frontiers》 SCIE EI 2022年第5期1354-1363,共10页
Ureas and carbamates are common motifs in pharmaceuticals,agrochemicals,biologically active com-pounds and organocatalysis applications.Herein,we report a significant advancement in this area and present a general met... Ureas and carbamates are common motifs in pharmaceuticals,agrochemicals,biologically active com-pounds and organocatalysis applications.Herein,we report a significant advancement in this area and present a general method for copper-catalyzed chemospecific C–C bond cleavage of amides to syn-thesize urea derivatives and carbamates at room temperature. 展开更多
关键词 TEMPERATURE CLEAVAGE BOND
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Fabrication of Electrospun PVDF Nanofibers with Higher Content of Polar β Phase and Smaller Diameter by Adding a Small Amount of Dioctadecyl Dimethyl Ammonium Chloride
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作者 wei xue cong lv +2 位作者 yao jing 陈枫 傅强 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2017年第8期992-1000,共9页
In this work,the effect of dioctadecyl dimethyl ammonium chloride(DDAC,a kind of alkyl ammonium salt) on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first time.Our... In this work,the effect of dioctadecyl dimethyl ammonium chloride(DDAC,a kind of alkyl ammonium salt) on polar β phase content and the diameter of electrospun PVDF nanofibers was investigated for the first time.Our experimental results show that the diameter of the electrospun PVDF nanofiber could be largely reduced and the content of polar β phase also become dominant immediately by just adding a little amount of DDAC.When the mass fraction of DDAC reached 4%,the content of polar β phase increased by about 39.1% compared with PVDF nanofibers without DDAC.Besides,the crystallinity of PVDF nanofibers also increased with the addition of DDAC.Based on the results,the possible mechanism of cooperative effect between electrospinning and DDAC on fiber diameter and formation of β phase in PVDF was discussed. 展开更多
关键词 Diameter crystalline crystallinity polar cooperative adding Polar ammonium alkyl attributed
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