Hepatitis B virus(HBV)infection is still a severe health problem in the world,and chronic hepatitis B(CHB)is the major cause of serious HBV-related complications,including fibrosis,hepatic failure,and hepatocellular c...Hepatitis B virus(HBV)infection is still a severe health problem in the world,and chronic hepatitis B(CHB)is the major cause of serious HBV-related complications,including fibrosis,hepatic failure,and hepatocellular carcinoma.It is difficult for CHB patients to achieve complete cure as the currently available antiviral drugs can hardly eradicate covalently closed circular DNA(cccDNA)in the infected liver.Since detecting intrahepatic cccDNA needs invasive procedure,it is urgent to find a noninvasive indicator to reflect the activity of cccDNA.Recently,growing numbers of studies have indicated that serum HBV RNA could be regarded as a new biomarker for CHB activity.In order to illustrate the molecular biology and clinical characteristics of HBV RNA,we systematically reviewed the latest research to summarize the role of HBV RNA in HBV replication and pathogenicity,and to better estimate its potential function as a remarkable biomarker in clinical application.Meanwhile,we will also point out the deficiencies of current research,and discuss the future direction of HBV RNA study.展开更多
基金This work was supported by National Key Basic Research Program of China(2014CB542102)National Key Research and Development Program of China(2016YFC1302303)+3 种基金National Human Genetic Resources Sharing Service Platform(2005DKA21300)Science Fund for Creative Research Groups,NSFC,China(81521091)State key infection disease project of China(2017ZX10203208)National Natural Science Foundation of China(81502375,81472691,81672345).
文摘Hepatitis B virus(HBV)infection is still a severe health problem in the world,and chronic hepatitis B(CHB)is the major cause of serious HBV-related complications,including fibrosis,hepatic failure,and hepatocellular carcinoma.It is difficult for CHB patients to achieve complete cure as the currently available antiviral drugs can hardly eradicate covalently closed circular DNA(cccDNA)in the infected liver.Since detecting intrahepatic cccDNA needs invasive procedure,it is urgent to find a noninvasive indicator to reflect the activity of cccDNA.Recently,growing numbers of studies have indicated that serum HBV RNA could be regarded as a new biomarker for CHB activity.In order to illustrate the molecular biology and clinical characteristics of HBV RNA,we systematically reviewed the latest research to summarize the role of HBV RNA in HBV replication and pathogenicity,and to better estimate its potential function as a remarkable biomarker in clinical application.Meanwhile,we will also point out the deficiencies of current research,and discuss the future direction of HBV RNA study.
