AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡand...AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡandⅢrectal cancer between January 2000 and December 2009[laparoscopic rectal resection(LRR),n=152;open rectal resection(ORR),n=254].Clinical characteristics,operative outcomes,pathological outcomes,postoperative recovery,and 5-year survival outcomes were compared between the two groups.RESULTS:Most of the clinical characteristics were similar except age(59 years vs 55 years,P=0.033)between the LRR group and ORR group.The proportion of anterior resection was higher in the LRR group than that in the ORR group(81.6%vs 66.1%,P=0.001).The LRR group had less estimated blood loss(50m L vs 200 m L,P<0.001)and a lower rate of blood transfusion(4.6%vs 11.8%,P=0.019)compared to the ORR group.The pathological outcomes of the two groups were comparable.The LRR group was associated with faster recovery of bowel function(2.8 d vs 3.7 d,P<0.001)and shorter postoperative hospital stay(11.7 d vs 13.7 d,P<0.001).The median followup time was 63 mo in the LRR group and 65 mo in the ORR group.As for the survival outcomes,the 5-year local recurrence rate(16.0%vs 16.4%,P=0.753),5-year disease-free survival(DFS)rate(63.0%vs63.1%,P=0.589),and 5-year overall survival(OS)rate(68.1%vs 63.5%,P=0.682)were comparable between the LRR group and the ORR group.Stageby stage,there were also no statistical differences between the LRR group and the ORR group in terms of the 5-year local recurrence rate(stageⅡ:6.3%vs 8.7%,P=0.623;stageⅢ:26.4%vs 23.2%,P=0.747),5-year DFS rate(stageⅡ:77.5%vs 77.6%,P=0.462;stageⅢ:46.5%vs 50.9%,P=0.738),and5-year OS rate(stageⅡ:81.4%vs 74.3%,P=0.242;stageⅢ:53.9%vs 54.1%,P=0.459).CONCLUSION:LRR for stagesⅡandⅢrectal cancer can yield comparable long-term survival while achieving short-term benefits compared to open surgery.展开更多
Situs inversus viscerum(SIV)is a rare congenitalcondition characterized by complete transposition of all viscera.This anatomical pathology makes endoscopic retrograde cholangiopancreatography(ERCP)technically difficul...Situs inversus viscerum(SIV)is a rare congenitalcondition characterized by complete transposition of all viscera.This anatomical pathology makes endoscopic retrograde cholangiopancreatography(ERCP)technically difficult.We report a new case of a 70-year-old Chinese male with total SIV who had obstructive jaundice.Magneticresonance cholangiopancreatography demonstrated a number of stones in the gallbladder and common bile duct(CBD).Therapeutic ERCP was performed to relieve biliary obstruction and remove the CBD stones.This procedure started with the patient in a supine position and the endoscopist at the left side of the table.When the papilla was maintained,the patient was repositioned to a prone position and standard endoscopic sphincterotomy and endoscopic papillary balloon dilatation procedures were conducted.ERCP was performed successfully and relevant complications did not occur in this patient.We also present a review of the literature published between 1985 and 2014in the Pub Med and EMBASE databases.There were eight published cases during this period,with one each from America,Finland,India,Italy,South Korea and Pakistan,and two from Spain.Our case is the first reported in China.展开更多
A new method for preparing effective inhibition film on copper has been developed. Phenylthiourea (PT) was first absorbed to copper surface to form a monolayer. 1-Dodecanethiol (DT) was then assembled on the surface...A new method for preparing effective inhibition film on copper has been developed. Phenylthiourea (PT) was first absorbed to copper surface to form a monolayer. 1-Dodecanethiol (DT) was then assembled on the surface for modification. Finally, AC voltage was loaded on copper covered the mixed film to improve it further. After these processes, an effective inhibition film was gained because of its high charge transfer resistance and low corrosion current density shown in electrochemical impedance spectra and polarization. The inhibition efficiency was more than 97%.展开更多
The electrocatalysts of Pt/C, PtRu/C and Ru/C were prepared by the impregnation method. The facet characterization, the dispersion and the particle size for the catalysts were determined by means of X ray diffractio...The electrocatalysts of Pt/C, PtRu/C and Ru/C were prepared by the impregnation method. The facet characterization, the dispersion and the particle size for the catalysts were determined by means of X ray diffraction and transmission electron microscopy. X ray photoelectron spectroscopy was also used to analyze the state and the valency of the noble metals. The results show that the particle size was in nanometer range and the binary metals have come into being an alloy. The platinum in the catalysts existed in zero valency. The valency of the ruthenium on the surface is different from that in the body, while the ruthenium on the surface existed in oxide form. PtRu/C and Pt/C are of good activity to the electrooxidation of hydrogen except Ru/C. PtRu/C is more tolerant of CO than Pt/C, and CO is only adsorbed on Pt.展开更多
Support vector machine (SVM) technique has recently become a research focus in intrusion detection field for its better generalization performance when given less priori knowledge than other soft-computing techniques....Support vector machine (SVM) technique has recently become a research focus in intrusion detection field for its better generalization performance when given less priori knowledge than other soft-computing techniques. But the randomicity of parameter selection in its implement often prevents it achieving expected performance. By utilizing genetic algorithm (GA) to optimize the parameters in data preprocessing and the training model of SVM simultaneously, a hybrid optimization algorithm is proposed in the paper to address this problem. The experimental results demonstrate that it’s an effective method and can improve the performance of SVM-based intrusion detection system further.展开更多
The great Kunlun earthquake occurred on Nov. 14, 2001 in Qinghai Province, China. Five large aftershocks with magnitude larger than 5.0 occurred near the Kunlun fault after main shock. Calculations of the change in Co...The great Kunlun earthquake occurred on Nov. 14, 2001 in Qinghai Province, China. Five large aftershocks with magnitude larger than 5.0 occurred near the Kunlun fault after main shock. Calculations of the change in Coulomb failure stress reveal that 4 of 5 large aftershocks occurred in areas with Dsf >0 (10-2~10-1 MPa) and one aftershock occurred in an area with Dsf =-0.56 MPa. It is concluded that the permanent fault displacement due to the main shock is the main cause of activity of large aftershocks, but not the whole cause.展开更多
Pervious studies demonstrate that lats, also known as warts, is a tumor suppressor gene in Drosophila . Mutations of lats lead to an increase in cell number and organ size in Drosophila, indicating lats may be involve...Pervious studies demonstrate that lats, also known as warts, is a tumor suppressor gene in Drosophila . Mutations of lats lead to an increase in cell number and organ size in Drosophila, indicating lats may be involved in organ size control. Furthermore, the high conservation of sequence and tumor suppression function of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals . So here we isolated the bovine homologue of Drosophila lats. Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins.展开更多
目的以膝下前扣带回到边缘系统相关脑区的功能连接为基础，寻找早期抗抑郁治疗疗效预测的生物学指标。方法随机入组32例抑郁症患者及20例健康对照，利用脑磁图数据计算基线膝下前扣带回到杏仁核、海马的theta波功能连接，以抗抑郁治疗2...目的以膝下前扣带回到边缘系统相关脑区的功能连接为基础，寻找早期抗抑郁治疗疗效预测的生物学指标。方法随机入组32例抑郁症患者及20例健康对照，利用脑磁图数据计算基线膝下前扣带回到杏仁核、海马的theta波功能连接，以抗抑郁治疗2周后17项汉密尔顿抑郁量表（HAMD17）总分减分率是否50％为标准划分患者为早期疗效有效组和无效组。比较各组功能连接，分析其与治疗2周后HAMD17，减分率的相关性。结果与对照组相比，抑郁症组膝下前扣带回与右侧杏仁核（MNI坐标：z=22，y=-2，Z=-15；F=6．90，P=0．012）、左侧杏仁核（MNI坐标：x=-24，y=-6，z=-16；F=5．75，P=0．020）、右侧海马（MNI坐标：x=30，y=-3，Z=-24；F=5．11，P=0．028）功能连接减弱。与治疗无效组相比，有效组膝下前扣带回与右侧杏仁核（F=12．417，P=0．0016）、右侧海马（F=8．74，P=0．0065）的功能连接较小。膝下前扣带回-右侧杏仁核（r=-0．56，P=0．0018）、膝下前扣带回-右侧海马（r=-0．50，P=0．0066）的功能连接与2周后HAMD17减分率呈负相关。ROC分析提示膝下前扣带回与右侧杏仁核[曲线下面积（area under cuwe，AUC）=0．73，JP=0．029]、右侧海马（AUC=0．71，P=0．042）可区分2周治疗效果。结论膝下前扣带回与右侧海马、右侧杏仁核基线时较高功能连接预示着较差的早期疗效，提示可能是抑郁症早期疗效预测的生物学指标。展开更多
基金Supported by National Key Clinical Specialty Construction Project of China,the National High Technology Research and Development Program of China No.2012AA021103the Research Fund of Public Welfare in Health Industry,National Health and Family Planning Commission of China,No.201502039
文摘AIM: To evaluate the 5-year survival after laparoscopic surgery vs open surgery for stages Ⅱ and Ⅲ rectal cancer.METHODS:This study enrolled 406 consecutive patients who underwent curative resection for stagesⅡandⅢrectal cancer between January 2000 and December 2009[laparoscopic rectal resection(LRR),n=152;open rectal resection(ORR),n=254].Clinical characteristics,operative outcomes,pathological outcomes,postoperative recovery,and 5-year survival outcomes were compared between the two groups.RESULTS:Most of the clinical characteristics were similar except age(59 years vs 55 years,P=0.033)between the LRR group and ORR group.The proportion of anterior resection was higher in the LRR group than that in the ORR group(81.6%vs 66.1%,P=0.001).The LRR group had less estimated blood loss(50m L vs 200 m L,P<0.001)and a lower rate of blood transfusion(4.6%vs 11.8%,P=0.019)compared to the ORR group.The pathological outcomes of the two groups were comparable.The LRR group was associated with faster recovery of bowel function(2.8 d vs 3.7 d,P<0.001)and shorter postoperative hospital stay(11.7 d vs 13.7 d,P<0.001).The median followup time was 63 mo in the LRR group and 65 mo in the ORR group.As for the survival outcomes,the 5-year local recurrence rate(16.0%vs 16.4%,P=0.753),5-year disease-free survival(DFS)rate(63.0%vs63.1%,P=0.589),and 5-year overall survival(OS)rate(68.1%vs 63.5%,P=0.682)were comparable between the LRR group and the ORR group.Stageby stage,there were also no statistical differences between the LRR group and the ORR group in terms of the 5-year local recurrence rate(stageⅡ:6.3%vs 8.7%,P=0.623;stageⅢ:26.4%vs 23.2%,P=0.747),5-year DFS rate(stageⅡ:77.5%vs 77.6%,P=0.462;stageⅢ:46.5%vs 50.9%,P=0.738),and5-year OS rate(stageⅡ:81.4%vs 74.3%,P=0.242;stageⅢ:53.9%vs 54.1%,P=0.459).CONCLUSION:LRR for stagesⅡandⅢrectal cancer can yield comparable long-term survival while achieving short-term benefits compared to open surgery.
文摘Situs inversus viscerum(SIV)is a rare congenitalcondition characterized by complete transposition of all viscera.This anatomical pathology makes endoscopic retrograde cholangiopancreatography(ERCP)technically difficult.We report a new case of a 70-year-old Chinese male with total SIV who had obstructive jaundice.Magneticresonance cholangiopancreatography demonstrated a number of stones in the gallbladder and common bile duct(CBD).Therapeutic ERCP was performed to relieve biliary obstruction and remove the CBD stones.This procedure started with the patient in a supine position and the endoscopist at the left side of the table.When the papilla was maintained,the patient was repositioned to a prone position and standard endoscopic sphincterotomy and endoscopic papillary balloon dilatation procedures were conducted.ERCP was performed successfully and relevant complications did not occur in this patient.We also present a review of the literature published between 1985 and 2014in the Pub Med and EMBASE databases.There were eight published cases during this period,with one each from America,Finland,India,Italy,South Korea and Pakistan,and two from Spain.Our case is the first reported in China.
基金Subsidized with the Special Funds for the Major State Basic Research Projects G19990650 and the Chinese National Science Fund (No. 20173033).
文摘A new method for preparing effective inhibition film on copper has been developed. Phenylthiourea (PT) was first absorbed to copper surface to form a monolayer. 1-Dodecanethiol (DT) was then assembled on the surface for modification. Finally, AC voltage was loaded on copper covered the mixed film to improve it further. After these processes, an effective inhibition film was gained because of its high charge transfer resistance and low corrosion current density shown in electrochemical impedance spectra and polarization. The inhibition efficiency was more than 97%.
基金Supported by the National 973project(No.G2 0 0 0 0 2 6 4 10 ) and Inovation Funds of Dalian Insitute of Chem icalPhysics
文摘The electrocatalysts of Pt/C, PtRu/C and Ru/C were prepared by the impregnation method. The facet characterization, the dispersion and the particle size for the catalysts were determined by means of X ray diffraction and transmission electron microscopy. X ray photoelectron spectroscopy was also used to analyze the state and the valency of the noble metals. The results show that the particle size was in nanometer range and the binary metals have come into being an alloy. The platinum in the catalysts existed in zero valency. The valency of the ruthenium on the surface is different from that in the body, while the ruthenium on the surface existed in oxide form. PtRu/C and Pt/C are of good activity to the electrooxidation of hydrogen except Ru/C. PtRu/C is more tolerant of CO than Pt/C, and CO is only adsorbed on Pt.
基金This work was supported by the Research Grant of SEC E-Institute :Shanghai High Institution Grid and the Science Foundation ofShanghai Municipal Commission of Science and Technology No.00JC14052
文摘Support vector machine (SVM) technique has recently become a research focus in intrusion detection field for its better generalization performance when given less priori knowledge than other soft-computing techniques. But the randomicity of parameter selection in its implement often prevents it achieving expected performance. By utilizing genetic algorithm (GA) to optimize the parameters in data preprocessing and the training model of SVM simultaneously, a hybrid optimization algorithm is proposed in the paper to address this problem. The experimental results demonstrate that it’s an effective method and can improve the performance of SVM-based intrusion detection system further.
基金The State Sciences and Technology Key Project During the Tenth Five-year Plan (2001BA601B02-02-04) China-Greece International Cooperative Research Project on Seismology and Chinese Joint Seismological Science Foundation (103073).
文摘The great Kunlun earthquake occurred on Nov. 14, 2001 in Qinghai Province, China. Five large aftershocks with magnitude larger than 5.0 occurred near the Kunlun fault after main shock. Calculations of the change in Coulomb failure stress reveal that 4 of 5 large aftershocks occurred in areas with Dsf >0 (10-2~10-1 MPa) and one aftershock occurred in an area with Dsf =-0.56 MPa. It is concluded that the permanent fault displacement due to the main shock is the main cause of activity of large aftershocks, but not the whole cause.
文摘Pervious studies demonstrate that lats, also known as warts, is a tumor suppressor gene in Drosophila . Mutations of lats lead to an increase in cell number and organ size in Drosophila, indicating lats may be involved in organ size control. Furthermore, the high conservation of sequence and tumor suppression function of lats between Drosophila and human suggests that it may be also involved in organ size control of higher animals . So here we isolated the bovine homologue of Drosophila lats. Sequence analysis indicates the bovine LATS1 to be very similar to other lats proteins.
文摘目的以膝下前扣带回到边缘系统相关脑区的功能连接为基础，寻找早期抗抑郁治疗疗效预测的生物学指标。方法随机入组32例抑郁症患者及20例健康对照，利用脑磁图数据计算基线膝下前扣带回到杏仁核、海马的theta波功能连接，以抗抑郁治疗2周后17项汉密尔顿抑郁量表（HAMD17）总分减分率是否50％为标准划分患者为早期疗效有效组和无效组。比较各组功能连接，分析其与治疗2周后HAMD17，减分率的相关性。结果与对照组相比，抑郁症组膝下前扣带回与右侧杏仁核（MNI坐标：z=22，y=-2，Z=-15；F=6．90，P=0．012）、左侧杏仁核（MNI坐标：x=-24，y=-6，z=-16；F=5．75，P=0．020）、右侧海马（MNI坐标：x=30，y=-3，Z=-24；F=5．11，P=0．028）功能连接减弱。与治疗无效组相比，有效组膝下前扣带回与右侧杏仁核（F=12．417，P=0．0016）、右侧海马（F=8．74，P=0．0065）的功能连接较小。膝下前扣带回-右侧杏仁核（r=-0．56，P=0．0018）、膝下前扣带回-右侧海马（r=-0．50，P=0．0066）的功能连接与2周后HAMD17减分率呈负相关。ROC分析提示膝下前扣带回与右侧杏仁核[曲线下面积（area under cuwe，AUC）=0．73，JP=0．029]、右侧海马（AUC=0．71，P=0．042）可区分2周治疗效果。结论膝下前扣带回与右侧海马、右侧杏仁核基线时较高功能连接预示着较差的早期疗效，提示可能是抑郁症早期疗效预测的生物学指标。
