Influenza caused by influenza virus,seriously threaten human life and health.Drug treatment is one of the effective measurement.However,there are only two classes of drugs,one class is M2 blockers and another is neura...Influenza caused by influenza virus,seriously threaten human life and health.Drug treatment is one of the effective measurement.However,there are only two classes of drugs,one class is M2 blockers and another is neuraminidase(NA) inhibitors.The recent antiviral surveillance studies reported a global significant increase in M2 blocker resistance among influenza viruses,and the resistant virus strains against NA inhibitor are also reported in clinical treatment.Therefore thediscovery of new medicines with low resistance has become very urgent.As all known,traditional medicines with multi-target features and network mechanism often possess low resistance.Compound Yizhihao,which consists of radix isatidis,folium isatidis,Artemisia rupestris,is one of the famous traditional medicine for influenza treatment in China,however its mechanism of action against influenza is unclear.In this study,the multiple targets related with influenza disease and the known chemical constituents from Compound Yizhihao were collected,and multi-target QSAR(mt-QSAR) classification models were developed by Na?e Bayesian algorithm and verified by various datasets.Then the classification models were applied to predict the effective constituents and their drug targets.Finally,the constituent-target-pathway network was constructed,which revealed the effective constituents and their network mechanism in Compound Yizhihao.This study will lay important basis for the clinical uses for influenza treatment and for the further research and development of the effective constituents.展开更多
Plant tolerance to aluminum(Al)toxicity can be enhanced by an ectomycorrhizal(ECM)fungus through biological filtering or physical blockage.To understand the roles of ECM colonization in Al absorption with regard to Al...Plant tolerance to aluminum(Al)toxicity can be enhanced by an ectomycorrhizal(ECM)fungus through biological filtering or physical blockage.To understand the roles of ECM colonization in Al absorption with regard to Al tolerance,Pinus massoniana seedlings were inoculated with either Lactarius deliciosus(L.:Fr.)Gray isolate 2 or Pisolithus tinctorius(Pers.)Coker et Couch isolate 715 and cultivated in an acid yellow soil with or without 1.0 mM Al^(3+)irrigation for 10 weeks.Biomass production,Al bioaccumulation and transport in seedlings colonized by the two ECM fungi were compared,and the three absorption kinetics(pseudo-first order,pseudo-second order and intraparticle diffusion)models used to evaluate variances in root Al^(3+)absorption capacity.Results show that both fungi increased aboveground biomass and Al tolerance of P.massoniana seedlings,but L.deliciosus 2 was more effective than P.tinctorius 715.Lower Al absorption capacity,fewer available active sites and decreased affinity and boundary layer thickness for Al^(3+),and higher Al accumulation and translocation contributed to the increased Al tolerance in the ECM-inoculated seedlings.These results advance our understanding of the mechanisms and strategies in plant Alto lerance conferred by ECM fungi and show that inoculation with L.deliciosus will better enhance Al tolerance in P.massoniana seedlings used for forest plantation and ecosystem restoration in acidic soils,particularly in Southwest China and similar soils worldwide.展开更多
Although high salt concentration electrolyte(HCE)can construct effective Li F-rich interphase film and solve the interphasial instability issue of graphite anode,its high cost,high viscosity and poor wettability with ...Although high salt concentration electrolyte(HCE)can construct effective Li F-rich interphase film and solve the interphasial instability issue of graphite anode,its high cost,high viscosity and poor wettability with electrode materials limit its large-scale application.Generally,localized high concentration electrolyte(LHCE)is obtained by introducing an electrochemically inert diluent into HCE to avoid the above-mentioned problems while maintaining the high interphasial stability of HCE with graphite anode.Unlike traditional inert diluents,1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluropropyl ether(TTE)with electrochemical activity is introduced into propylene carbonate(PC)-based HCE to obtain LHCE-2(1 M LiPF_(6),PC:DMC:TTE=1:1:6.1)herein.Experimental and theoretical simulation results show that TTE participates in the oxidation decomposition and film-forming reaction at the NCM622 cathode surface,conducting a cathode electrolyte interphase(CEI)rich in organic fluorides with excellent electron insulation ability,high structural stability and low interphasial impedance.Thanks to the outstanding interphasial properties induced by LHCE-2,the graphite||NMC622 pouch cell reaches a capacity retention of 80%after 500 cycles at 1 C under room temperature.While at sub-zero temperatures,the capacity released by the cell with LHCE-2 electrolyte is significantly higher than that of HCE and conventional EC-based electrolytes.Meanwhile,the LHCE-2 electrolyte inherits the advantages of TTE flame-resistant,thus improving the safety of the battery.展开更多
Drop weight impact tester was used to accurately measure the bending impact resistance of various parts of Phyllostachys edulis,commonly known as moso bamboo,with a growth cycle of 3–8 years.Cellulose crystallinity i...Drop weight impact tester was used to accurately measure the bending impact resistance of various parts of Phyllostachys edulis,commonly known as moso bamboo,with a growth cycle of 3–8 years.Cellulose crystallinity in the bottom(B),middle(M)and top(T)of bamboo at different ages was calculated using peak height analysis in X-ray diffraction.Heatmap of Spearman correlation analysis was used to represent the correlation between chemical composition and impact mechanics.The breaking load(BL),fracture energy(FE)and impact deflection(ID)of 3–8-year-old bamboo were found to be in the range of~670–2120 N,~5.17–15.55 J,and~3.60–~17.76 mm,respectively.As the growth period of bamboo rises,the cellulose crystallinity at the B and T decreases first and then increases,while that for the M increases first and then remains stable.Similarly,the bending impact performance of bamboo was found to become stable with its growth and age.The flexural impact and toughness of the 4-year-old bamboo base material were better than other specimens.The enhancement in the bending impact properties of bamboo at different growth periods was influenced by the lignin content,while the value of FE was mainly positively correlated with ash,cold and hot water extracts and benzyl alcohol content.However the content of holocellulose and pentosan,air-dry density and,base density negatively influenced the FE.With the change in the height of the bamboo,the correlation between its impact mechanical properties and chemical composition gradually decreased.This study provides data support and theoretical basis for the age-appropriate thinning and application of moso bamboo.展开更多
基金supported by National Natural Science Foundation of China(81673480) Project of Urumqi science and Technology Bureau of the Xinjiang Uygur Autonomous Region(Y151310010)
文摘Influenza caused by influenza virus,seriously threaten human life and health.Drug treatment is one of the effective measurement.However,there are only two classes of drugs,one class is M2 blockers and another is neuraminidase(NA) inhibitors.The recent antiviral surveillance studies reported a global significant increase in M2 blocker resistance among influenza viruses,and the resistant virus strains against NA inhibitor are also reported in clinical treatment.Therefore thediscovery of new medicines with low resistance has become very urgent.As all known,traditional medicines with multi-target features and network mechanism often possess low resistance.Compound Yizhihao,which consists of radix isatidis,folium isatidis,Artemisia rupestris,is one of the famous traditional medicine for influenza treatment in China,however its mechanism of action against influenza is unclear.In this study,the multiple targets related with influenza disease and the known chemical constituents from Compound Yizhihao were collected,and multi-target QSAR(mt-QSAR) classification models were developed by Na?e Bayesian algorithm and verified by various datasets.Then the classification models were applied to predict the effective constituents and their drug targets.Finally,the constituent-target-pathway network was constructed,which revealed the effective constituents and their network mechanism in Compound Yizhihao.This study will lay important basis for the clinical uses for influenza treatment and for the further research and development of the effective constituents.
基金supported by the National Natural Science Foundation of China (31570599 and 32171753)。
文摘Plant tolerance to aluminum(Al)toxicity can be enhanced by an ectomycorrhizal(ECM)fungus through biological filtering or physical blockage.To understand the roles of ECM colonization in Al absorption with regard to Al tolerance,Pinus massoniana seedlings were inoculated with either Lactarius deliciosus(L.:Fr.)Gray isolate 2 or Pisolithus tinctorius(Pers.)Coker et Couch isolate 715 and cultivated in an acid yellow soil with or without 1.0 mM Al^(3+)irrigation for 10 weeks.Biomass production,Al bioaccumulation and transport in seedlings colonized by the two ECM fungi were compared,and the three absorption kinetics(pseudo-first order,pseudo-second order and intraparticle diffusion)models used to evaluate variances in root Al^(3+)absorption capacity.Results show that both fungi increased aboveground biomass and Al tolerance of P.massoniana seedlings,but L.deliciosus 2 was more effective than P.tinctorius 715.Lower Al absorption capacity,fewer available active sites and decreased affinity and boundary layer thickness for Al^(3+),and higher Al accumulation and translocation contributed to the increased Al tolerance in the ECM-inoculated seedlings.These results advance our understanding of the mechanisms and strategies in plant Alto lerance conferred by ECM fungi and show that inoculation with L.deliciosus will better enhance Al tolerance in P.massoniana seedlings used for forest plantation and ecosystem restoration in acidic soils,particularly in Southwest China and similar soils worldwide.
基金supported by the National Natural Science Foundation of China (No.21972049)the Guangdong-Hong KongMacao Greater Bay Area Exchange Programs of SCNU (2022)。
文摘Although high salt concentration electrolyte(HCE)can construct effective Li F-rich interphase film and solve the interphasial instability issue of graphite anode,its high cost,high viscosity and poor wettability with electrode materials limit its large-scale application.Generally,localized high concentration electrolyte(LHCE)is obtained by introducing an electrochemically inert diluent into HCE to avoid the above-mentioned problems while maintaining the high interphasial stability of HCE with graphite anode.Unlike traditional inert diluents,1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluropropyl ether(TTE)with electrochemical activity is introduced into propylene carbonate(PC)-based HCE to obtain LHCE-2(1 M LiPF_(6),PC:DMC:TTE=1:1:6.1)herein.Experimental and theoretical simulation results show that TTE participates in the oxidation decomposition and film-forming reaction at the NCM622 cathode surface,conducting a cathode electrolyte interphase(CEI)rich in organic fluorides with excellent electron insulation ability,high structural stability and low interphasial impedance.Thanks to the outstanding interphasial properties induced by LHCE-2,the graphite||NMC622 pouch cell reaches a capacity retention of 80%after 500 cycles at 1 C under room temperature.While at sub-zero temperatures,the capacity released by the cell with LHCE-2 electrolyte is significantly higher than that of HCE and conventional EC-based electrolytes.Meanwhile,the LHCE-2 electrolyte inherits the advantages of TTE flame-resistant,thus improving the safety of the battery.
基金Fundamental Research on Impact Toughness and Response Mechanism of Bamboo-woven Structural Materials Funded of International Center for Bamboo and Rattan(1632020016).
文摘Drop weight impact tester was used to accurately measure the bending impact resistance of various parts of Phyllostachys edulis,commonly known as moso bamboo,with a growth cycle of 3–8 years.Cellulose crystallinity in the bottom(B),middle(M)and top(T)of bamboo at different ages was calculated using peak height analysis in X-ray diffraction.Heatmap of Spearman correlation analysis was used to represent the correlation between chemical composition and impact mechanics.The breaking load(BL),fracture energy(FE)and impact deflection(ID)of 3–8-year-old bamboo were found to be in the range of~670–2120 N,~5.17–15.55 J,and~3.60–~17.76 mm,respectively.As the growth period of bamboo rises,the cellulose crystallinity at the B and T decreases first and then increases,while that for the M increases first and then remains stable.Similarly,the bending impact performance of bamboo was found to become stable with its growth and age.The flexural impact and toughness of the 4-year-old bamboo base material were better than other specimens.The enhancement in the bending impact properties of bamboo at different growth periods was influenced by the lignin content,while the value of FE was mainly positively correlated with ash,cold and hot water extracts and benzyl alcohol content.However the content of holocellulose and pentosan,air-dry density and,base density negatively influenced the FE.With the change in the height of the bamboo,the correlation between its impact mechanical properties and chemical composition gradually decreased.This study provides data support and theoretical basis for the age-appropriate thinning and application of moso bamboo.
