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HLA-C端粒端150kb区域与犹太人群银屑病相关
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作者 jewish population martnez-borra j. BrautbarC. +2 位作者 González S. C. López-Larrea 朱国兴 《世界核心医学期刊文摘(皮肤病学分册)》 2006年第8期19-20,共2页
The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been p... The HLA-Cw 0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw 0602 nor the allele CDSN TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1-4- 4 (OR = 2.6, 95% CI = 1.4- 4.7, Pc =0.018) the octamer transcription factor (OTF)- 3 gene (OR = 2.6, 95% CI = 1.6- 4.3, Pc = 0.0001) and the α -helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3- 4.5, Pc = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene. 展开更多
关键词 种族人群 银屑病 HLA-Cw*0602 端粒 病例对照研究 RS1基因 多态性基因 基因分型 等位基因 易感性
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