基于空气动力学的战术红外干扰弹多元气动特性研究

在红外干扰弹自身特性研究领域中,与其相对静态的辐射特性研究相比,其复杂多变的动态气动特性研究对于实战应用显得尤为重要。为此,本文针对红外干扰弹多元气动特性影响,利用空气动力学原理及大气模型,系统分析了红外干扰弹的飞行速度与马赫数之间的紧密关系,进而高效模拟了红外干扰弹气动模型在三维立体空间中的作用效果。通过VC++.net及OpenGL开发工具对干扰弹的实际弹道模型进行综合模拟仿真设计实验,将红外干扰弹的气动特性进行自适应调节,基本达到了预期的改进目标,进而为红外干扰弹改进实战效能提供了有力支撑。

Primary hepatoid adenocarcinoma of the lung in Yungui Plateau,China:A case report

BACKGROUND Hepatoid adenocarcinoma (HAC) occurs in extrahepatic organs such as the gastrointestinal tract, testes, ovaries, lungs, mediastinum and pancreas, and frequently produces α-fetoprotein (AFP). HAC of the lung (HAL) is rare, characterized by difficult treatment and poor prognosis. There are no reports of HAL in Yunnan-Guizhou Plateau, China. CASE SUMMARY A 60-year-old male patient was clinically diagnosed with HAL pT3NOM0, stage IIB. Chest computed tomography revealed a 7.5 cm × 7.2 cm soft tissue mass located in the right lung upper lobe and the adjacent superior mediastinum. Right upper lobectomy was performed. The diagnosis of HAL was confirmed by pathological examination, and the patient received paclitaxel and carboplatin as adjuvant chemotherapy after surgery. CONCLUSION Clinical manifestations, pathological features, imaging findings, auxiliary examination, and treatment planning of HAL are presented to help clinicians improve their diagnosis and treatment.

井温测井数据在湖北中深层地热勘查中的多效应用

井温测井作为常规物探手段,广泛应用于多数地热勘查项目。基于大量测井生产实践经验,以湖北省两处中深层地热井为例,总结在不同监测模式和监测环境下,应用井温测井数据解决地温梯度读取、高温层及涌水层识别、套管查漏、裂隙观测等实际生产问题的方法。利用静态井温监测数据和地温梯度变化曲线,可有效识别高温层,并准确采集地温梯度数据。利用动态井温监测数据和井温梯度变化曲线,可在复杂环境下有效识别涌水层,并定性判断涌水量大小。利用动态井温监测曲线的微小异常,可有效识别套管破损等固井情况。在地热勘查中充分灵活地应用井温测井数据能有效提高勘查工作效率并降低工作成本。

A Parallel FEA Computing Kernel for Building Structures

With the rapid development of high-rise buildings and long-span structures in the recent years, high performance com- putation (HPC) is becoming more and more important, sometimes even crucial, for the design and construction of com- plex building structures. To satisfy the engineering requirements of HPC, a parallel FEA computing kernel, which is designed typically for the analysis of complex building structures, will be presented and illustrated in this paper. This kernel program is based on the Intel Math Kernel Library (MKL) and coded by FORTRAN 2008 syntax, which is a parallel computer language. To improve the capability and efficiency of the computing kernel program, the parallel concepts of modern FORTRAN, such as elemental procedure, do concurrent, etc., have been applied extensively in coding and the famous PARDISO solver in MKL has been called to solve the Large-sparse system of linear equations. The ultimate objective of developing the computing kernel is to make the personal computer have the ability to analysis large building structures up to ten million degree of freedoms (DOFs). Up to now, the linear static analysis and dynamic analysis have been achieved while the nonlinear analysis, including geometric and material nonlinearity, has not been finished yet. Therefore, the numerical examples in this paper will be concentrated on demonstrating the validity and efficiency of the linear analysis and modal analysis for large FE models, while ignoring the verification of the nonlinear analysis capabilities.

Reversal of idiopathic hypogonadotropic hypogonadism： a cohort study in Chinese patients

Although idiopathic hypogonadotropic hypogonadism （IHH） has traditionally been viewed as a life-long disease caused by a deficiency of gonadotropin-releasing hormone neurons, a portion of patients may gradually regain normal reproductive axis function during hormonal replacement therapy. The predictive factors for potential IHH reversal are largely unknown. The aim of our study was to investigate the incidence and clinical features of IHH male patients who had reversed reproductive axis function. In this retrospective cohort study, male IHH patients were classified into a reversal group （n = 18） and a nonreversal group （n = 336）. Concentration of gonadotropins and testosterone, as well as testicle sizes and sperm counts, were determined. Of 354 IHH patients, 18 （5.1%） acquired normal reproductive function during treatment. The median age for reversal was 24 years old （range 21-34 years）. Compared with the nonreversal group, the reversible group had higher basal luteinizing hormone （LH） （1,0±0.7 IU 1-1 vs 0.4±0.4 IU 1-1, P 〈 0.05） and stimulated LH （28.3 ± 22.6 IU 1-1 vs 1.9 ±1.1 IU 1-1, P 〈 0.01） levels, as well as larger testicle size （5.1 ±2.6 ml vs 1.5± 0.3 ml, P〈 0.01）, at the initial visit. In summary, larger testicle size and higher stimulated LH concentrations are favorite parameters for reversal. Our finding suggests that reversible patients may retain partially active reproductive axis function at initial diagnosis.

Greatly Enhanced Hydrolytic Degradation Ability of Poly(L-lactide) Achieved by Adding Poly(ethylene glycol)

Plasticized poly(L-lactide)(PLLA) materials have been applied in many fields and the microstructure performance of such materials attracts much attention of researchers. However, few reports declared the hydrolytic degradation ability of the plasticized PLLA materials. In this article, a small quantity of poly(ethylene glycol)(PEG) was introduced into PLLA, which aimed to understand the hydrolytic degradation behavior of the plasticized PLLA materials. The microstructures of the plasticized samples were comparatively investigated using scanning electron microscopy(SEM), wide angle X-ray diffraction(WAXD), differential scanning calorimetry(DSC) and Flourier transform infrared spectroscopy(FTIR), etc. The results demonstrated that PEG improved the hydrophilicity of sample surface, and the relatively high content of PEG enhanced the crystallization ability of PLLA matrix. The hydrolytic degradation measurement was carried out at 60 ℃ in an alkaline solution of pH = 12. The results demonstrated that the plasticized PLLA samples exhibited accelerated hydrolytic degradation compared with the pure PLLA sample, and the hydrolytic degradation was also dependent on the PEG content. Further results demonstrated that PEG induced the change of hydrolytic degradation mechanism possibly due to the good dissolution ability of PEG in water, which provided more paths for the penetration of water. Furthermore, the microstructure evolution of the plasticized PLLA during the hydrolytic degradation process was also investigated, and the results demonstrated the occurrence of PLLA crystallization, which was possibly contributed to the decreased hydrolytic degradation rate observed at relatively long hydrolytic degradation time. This work is of great significance and may open a new way for promoting the reclamation of PLLA waste material.

Inhibition of Magnolol and Honokiol on Cytochrome P450 Enzymes in Rat and Human Liver Microsomes

Objective The purpose of this work is to evaluate the in vitro inhibitory effect of magnolol（MN） and honokiol（HN） on rat / human cytochrome P450（CYP） enzymes（1A2/1A2, 2D/2D6, 3A/3A4, 2E1/2E1, and 2C/2C9）. Methods Rat liver microsomes（RLM） and human liver microsomes（HLM） were used as the enzyme sources. After the probe substrate of each CYP isoforms was co-incubated individually with MN or HN in RLM or HLM, the metabolite production of each probe substrate in RLM and HLM incubation medium was determined and used to evaluate the activity of corresponding CYP isoforms. Results MN inhibited rat CYP1A2 and human CYP3A4 with the IC50 values of 10.0 and 56.2 μmol/L, respectively. HN inhibited rat CYP1A2 and CYP2E1, human CYP1A2 and CYP3A4 with the IC50 values of 12.1, 12.6, 17.8, and 43.9 μmol/L, respectively. Conclusion HN is a moderate or weak inhibitor of human CYP1A2. Both MN and HN are weak or non inhibitors of the other tested human CYP isoforms. The results suggest that no significant metabolic interaction seems likely to occur when the substrate drugs of CYP isoforms tested in the present work are co-administered with MN and HN.

An evaluation approach to spatial identity in historic urban areas from a humanistic perspective

Urban spatial identity,as the core content of a distinctive urban image and the representation of urban competitiveness and attraction,is critical to cities in the rapid development process.In view of maintaining and strengthening the spatial identity in a historic urban area,which is the key issue of urban construction in China at present,based on the literature review of Chinese urban spatial identity studies,three research paradigms are summarized:landscape,culture,and economy.Although the traditional evaluation method of spatial identity in historic urban areas has focused on the scarcity of characteristic resources,the relation-ship between characteristic resources and human beings has been ignored.Therefore,based on the declaration of the fundamental mechanism of urban spatial identity in historic urban areas,a new evaluation method was proposed considering four aspects,including object,subject,content,and indicators.The results indicated that the framework of evaluation and design,which is based on the assessment of the relationship between characteristic resources and human beings,is an effective strategy to improve the scientific evaluation of urban spatial identity.Our study has substantial implications for urban planners and managers in solving the urban identity crisis issue in historic urban areas.

People-oriented urban design

Since the beginning of the 21st century,more than half of the world's population has lived in cities.Urbanization is developing rapidly around the world.However,it is not a monolithic or linear development,but presents a variety of forms.Cities have become diverse and ambiguous.The connections between cities have transcended national borders,and formed networks with each other.In turn,this also puts the city in the complex dynamic changes.In every corner of the world,there are endless challenges faced by urban planners and city authorities.Building an academic platform for people-oriented urban design is of positive significance for carrying out research on major scientific issues and key technologies in the field of urban design.