Purpose: To examine the association between potential risk factors and the 14 -year incidence of age-related maculopathy (ARM). Design: Population-based co hort study. Participants: At baseline, 946 volunteers partici...Purpose: To examine the association between potential risk factors and the 14 -year incidence of age-related maculopathy (ARM). Design: Population-based co hort study. Participants: At baseline, 946 volunteers participated in the study during 1986-88. These subjects were between 60 and 80 years of age and lived in the terbro district of Copenhagen. Excluding participants who had died since baseline, 359 subjects (97.3%of survivors) were reexamined 14 years later, duri ng 2000-2002. A total of 31.8%(301/946) of the original material was included in the risk factor analyses. Methods: Participants underwent an ophthalmological examination at Rigshospitalet, the National University Hospital of Copenhagen. Similar standardized protocols for physical examination were used at the baselin e and follow-up examinations. Age-relatedm- aculopa-thy lesionswere determined by the same grader grading colour fundus p hotographs from both examinations using a modification of the Wisconsin Age-rel ated Maculopathy Grading System protocol. Results: Of the 359 participants, 94 h ad incident early ARM and 52 had incident late ARM at follow-up in either eye. In logistic regression, the risk factors for early ARM or worse were as follows: cataract (odds ratio [OR] 2.8, 95%confidence interval [CI] 1.2-6.2); fami ly h istory of ARM (OR 4.5, 95%CI 1.3-15.5), and alcohol consumption >250 g/week (O R 4.6, 95%CI 1.1-19.2). High levels of apolipoprotein B ( > 100 mg/1) decrease d the risk of development of early ARM or worse (OR 0.4, 95%CI 0.2-0.8), while high levels of apolipoprotein A1 (≥150 mg/1) increased the risk of late ARM (O R 2.5, 95%CI 1.2-5.3). Advanced age at baseline was also associated with the i ncidence of late ARM(OR2.0, 95%CI 1.4-2.9). Conclusions: These findings indica te a direct correlation between age, cataract, family history, alcohol consumpti on, the apolipoproteins A1 and B and the 14-year incidence of ARM.展开更多
Purpose: To examine patient survival in age- related maculopathy in a 14- year follow- up study. Design: Population- based 14- year cohort study. Participants: Nine hundred forty- six residents, aged 60 to 80 years, l...Purpose: To examine patient survival in age- related maculopathy in a 14- year follow- up study. Design: Population- based 14- year cohort study. Participants: Nine hundred forty- six residents, aged 60 to 80 years, living in the sterbro district of Copenhagen, Denmark, participated in the first examination conducted from 1986 to 1988. These participants were followed until death or until May 1, 2002, whichever came first. Methods: Participants underwent an extensive ophthalmologic examination at Rigshospitalet, the National University Hospital of Copenhagen. Standardized protocols for physical examination, blood samples, and data from the National Central Person Register, the National Death Register, and the National Patient Register were used. Main Outcome Measures: Mortality and age- related maculopathy. Results: By May 1, 2002, 60.9% (577 of 946) of the participants of the baseline study cohort had died. The adjusted 14- year cumulative mortality hazard ratio for subjects with early and late age- related maculopathy at baseline was 1.26 (95% confidence interval [CI], 1.06- 1.51). We identified a strong correlation between mortality and agerelated maculopathy among women (relative risk, 1.59; 95% CI, 1.23- 2.07) but not among men. Conclusions: When adjusting for survival- related factors, age- related maculopathy is a significant risk indicator for poorer survival in women and may be amarker of underlying serious systemic factors or aging processes specific to women.展开更多
文摘Purpose: To examine the association between potential risk factors and the 14 -year incidence of age-related maculopathy (ARM). Design: Population-based co hort study. Participants: At baseline, 946 volunteers participated in the study during 1986-88. These subjects were between 60 and 80 years of age and lived in the terbro district of Copenhagen. Excluding participants who had died since baseline, 359 subjects (97.3%of survivors) were reexamined 14 years later, duri ng 2000-2002. A total of 31.8%(301/946) of the original material was included in the risk factor analyses. Methods: Participants underwent an ophthalmological examination at Rigshospitalet, the National University Hospital of Copenhagen. Similar standardized protocols for physical examination were used at the baselin e and follow-up examinations. Age-relatedm- aculopa-thy lesionswere determined by the same grader grading colour fundus p hotographs from both examinations using a modification of the Wisconsin Age-rel ated Maculopathy Grading System protocol. Results: Of the 359 participants, 94 h ad incident early ARM and 52 had incident late ARM at follow-up in either eye. In logistic regression, the risk factors for early ARM or worse were as follows: cataract (odds ratio [OR] 2.8, 95%confidence interval [CI] 1.2-6.2); fami ly h istory of ARM (OR 4.5, 95%CI 1.3-15.5), and alcohol consumption >250 g/week (O R 4.6, 95%CI 1.1-19.2). High levels of apolipoprotein B ( > 100 mg/1) decrease d the risk of development of early ARM or worse (OR 0.4, 95%CI 0.2-0.8), while high levels of apolipoprotein A1 (≥150 mg/1) increased the risk of late ARM (O R 2.5, 95%CI 1.2-5.3). Advanced age at baseline was also associated with the i ncidence of late ARM(OR2.0, 95%CI 1.4-2.9). Conclusions: These findings indica te a direct correlation between age, cataract, family history, alcohol consumpti on, the apolipoproteins A1 and B and the 14-year incidence of ARM.
文摘Purpose: To examine patient survival in age- related maculopathy in a 14- year follow- up study. Design: Population- based 14- year cohort study. Participants: Nine hundred forty- six residents, aged 60 to 80 years, living in the sterbro district of Copenhagen, Denmark, participated in the first examination conducted from 1986 to 1988. These participants were followed until death or until May 1, 2002, whichever came first. Methods: Participants underwent an extensive ophthalmologic examination at Rigshospitalet, the National University Hospital of Copenhagen. Standardized protocols for physical examination, blood samples, and data from the National Central Person Register, the National Death Register, and the National Patient Register were used. Main Outcome Measures: Mortality and age- related maculopathy. Results: By May 1, 2002, 60.9% (577 of 946) of the participants of the baseline study cohort had died. The adjusted 14- year cumulative mortality hazard ratio for subjects with early and late age- related maculopathy at baseline was 1.26 (95% confidence interval [CI], 1.06- 1.51). We identified a strong correlation between mortality and agerelated maculopathy among women (relative risk, 1.59; 95% CI, 1.23- 2.07) but not among men. Conclusions: When adjusting for survival- related factors, age- related maculopathy is a significant risk indicator for poorer survival in women and may be amarker of underlying serious systemic factors or aging processes specific to women.
