Background: Hypertension is a universal risk factor for cardiovascular diseases and is thus the leading cause of death worldwide. The identification of novel prognostic and pathogenesis biomarkers plays a key role in ...Background: Hypertension is a universal risk factor for cardiovascular diseases and is thus the leading cause of death worldwide. The identification of novel prognostic and pathogenesis biomarkers plays a key role in disease management. Methods: The GSE145854 and GSE164494 datasets were downloaded from the Gene Expression Omnibus (GEO) database and used for screening and validating hypertension signature genes, respectively. Gene Ontology (GO) enrichment analysis was performed on the differentially expressed genes (DEGs) related to calcium ion metabolism in patients with hypertension. The core genes related to immune infiltration were analyzed and screened, and the activity of the signature genes and related pathways was quantified using gene set enrichment analysis (GSEA). The infiltration of immune cells in the blood samples was analyzed, and the DEGs that were abnormally expressed in the clinical blood samples of patients with hypertension were verified via RT-qPCR. Results: A total of 176 DEGs were screened. GO showed that DEGs was involved in the regulation of calcium ion metabolism in biological processes (BP), actin mediated cell contraction, negative regulation of cell movement, and calcium ion transmembrane transport, and in the regulation of protease activity in molecular functions (MF). KEGG analysis revealed that the DEGs were involved mainly in the cGMP-PKG signaling pathway, ubiquitin-protein transferase, tight junction-associated proteins, and the regulation of myocardial cells. MF analysis revealed the immune infiltration function of the cells. RT-qPCR revealed that the expression of Cacna1d, Serpine1, Slc8a3, and Trpc4 was up regulated in hypertension, the expression of Myoz2 and Slc25a23 was down regulated. Conclusion: Cacna1d, Serpine1, Slc8a3, Trpc4, Myoz2 and Slc25a23 may be involved in the regulation of calcium metabolism pathways and play key roles in hypertension. These differentially expressed calcium metabolism-related genes may serve as prognostic markers of hypertension.展开更多
Background: Hypertension, also known as increased blood pressure, is a phenomenon in which blood flows in blood vessels and causes persistently higher-than-normal pressure on the vessel wall. The identification of nov...Background: Hypertension, also known as increased blood pressure, is a phenomenon in which blood flows in blood vessels and causes persistently higher-than-normal pressure on the vessel wall. The identification of novel prognostic and pathogenesis biomarkers plays a key role in the management of hypertension. Methods: The GSE7483 and GSE75815 datasets from the gene expression omnibus (GEO) database were used to identify the genes associated with hypertension that were differentially expressed genes (DEGs). The functional role of the DEGs was elucidated by gene body (GO) enrichment analysis. In addition, we performed an immune infiltration assay and GSEA on the DEGs of hypertensive patients and verified the expression of novel DEGs in the blood of hypertensive patients by RT-qPCR. Results: A total of 267 DEGs were identified from the GEO database. GO analysis revealed that these genes were associated mainly with biological processes such as fibroblast proliferation, cell structural organization, extracellular matrix organization, vasculature development regulation, and angiogenesis. We identified five possible biomarkers, Ecm1, Sparc, Sphk1, Thbsl, and Mecp2, which correlate with vascular development and angiogenesis characteristic of hypertension by bioinformatics, and explored the clinical expression levels of these genes by RT-qPCR, and found that Sparc, Sphk1, and Thbs1 showed significant up-regulation, in agreement with the results of the bioinformatics analysis. Conclusion: Our study suggested that Sparc, Sphk1 and Thbs1 may be potential novel biomarkers for the diagnosis, treatment and prognosis of hypertension and that they are involved in the regulation of vascular development and angiogenesis in hypertension.展开更多
Boron is an important industrial raw material often sourced from minerals containing different compounds that cocrystallize,which makes it difficult to separate the mineral phases through conventional beneficiation.Th...Boron is an important industrial raw material often sourced from minerals containing different compounds that cocrystallize,which makes it difficult to separate the mineral phases through conventional beneficiation.This study proposed a new treatment called flash reduction-melting separation(FRMS)for boron-bearing iron concentrates.In this method,the concentrates were first flash-reduced at the temperature under which the particles melt,and the slag and the reduced iron phases disengaged at the particle scale.Good reduc-tion and melting effects were achieved above 1550℃.The B_(2)O_(3) content in the separated slag was over 18wt%,and the B content in the iron was less than 0.03wt%.The proposed FRMS method was tested to investigate the effects of factors such as ore particle size and tem-perature on the reduction and melting steps with and without pre-reducing the raw concentrate.The mineral phase transformation and morphology evolution in the ore particles during FRMS were also comprehensively analyzed.展开更多
As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in 2020.Due to its highly immunogenic...As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in 2020.Due to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still exist.In addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor progression.The aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of immunotherapies.Therefore,personalized treatments could be developed to maximize the advantages of immunotherapy.展开更多
Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant sows.Seven solvent-extracte...Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant sows.Seven solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were selected.In Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N source.Eight non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in Exp.1.Eight gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation stages.Results When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,Gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(P<0.05),whereas SID for Leu from SBM 5 was higher than in SBM 1 and 4(P<0.05).SID values for Ile,Ala,and Asp from SBM 4 were lower than in SBM 1 and 5(P<0.05).Sows had significantly greater SID values for Lys,Ala,and Asp during mid-gestation when compared with late-gestation stages(P<0.05).Mid-gestating sows had greater SID value for Val and lower SID value for Tyr when compared with non-pregnant and late-gestating sows(P<0.01),whereas non-pregnant sows had significantly greater SID value for Met when compared with gestating sows(P<0.01).Conclusions When fed to mid-gestating sows,the SID values for most AAs varied among SBM samples.The SID values for Lys,Met,Val,Ala,Asp,and Tyr in SBM were affected by sow gestation stages.Our findings provide a cornerstone for accurate SBM use in sow diets.展开更多
Gastric cancer(GC)is defined as the primary epithelial malignancy derived from the stomach,and it is a complicated and heterogeneous disease with multiple risk factors.Despite its overall declining trend of incidence ...Gastric cancer(GC)is defined as the primary epithelial malignancy derived from the stomach,and it is a complicated and heterogeneous disease with multiple risk factors.Despite its overall declining trend of incidence and mortality in various countries over the past few decades,GC remains the fifth most common malignancy and the fourth leading cause of cancer-related death globally.Although the global burden of GC has shown a significant downward trend,it remains severe in certain areas,such as Asia.GC ranks third in incidence and mortality among all cancer types in China,and it accounts for nearly 44.0%and 48.6%of new GC cases and GC-related deaths in the world,respectively.The regional differences in GC incidence and mortality are obvious,and annual new cases and deaths are increasing rapidly in some developing regions.Therefore,early preventive and screening strategies for GC are urgently needed.The clinical efficacies of conventional treatments for GC are limited,and the developing understanding of GC pathogenesis has increased the demand for new therapeutic regimens,including immune checkpoint inhibitors,cell immunotherapy and cancer vaccines.The present review describes the epidemiology of GC worldwide,especially in China,summarizes its risk and prognostic factors,and focuses on novel immunotherapies to develop therapeutic strategies for the management of GC patients.展开更多
Sluggish reaction kinetics of oxygen evolution reaction(OER), resulting from multistep proton-coupled electron transfer and spin constriction, limits overall efficiency for most reported catalysts. Herein, using model...Sluggish reaction kinetics of oxygen evolution reaction(OER), resulting from multistep proton-coupled electron transfer and spin constriction, limits overall efficiency for most reported catalysts. Herein, using modeled ZnFe_(2-x)Ni_xO_(4)(0 ≤ x ≤ 0.4) spinel oxides, we aim to develop better OER electrocatalyst through combining the construction of ferromagnetic(FM) ordering channels and generation of highly active reconstructed species. The number of symmetry-breaking Fe–O–Ni structure links to the formation of FM ordering electron transfer channels. Meanwhile, as the number of Ni^(3+)increases, more ligand holes are formed, beneficial for redirecting surface reconstruction. The electro-activated ZnFe_(1.6)Ni_(0.4)O_(4) shows the highest specific activity, which is 13 and 2.5 times higher than that of ZnFe_(2)O_(4) and unactivated ZnFe_(1.6)Ni_(0.4)O_(4), and even superior to the benchmark IrO_(2) under the overpotential of 350 mV. Applying external magnetic field can make electron spin more aligned, and the activity can be further improved to 39 times of ZnFe_(2)O_(4). We propose that intriguing FM exchange-field interaction at FM/paramagnetic interfaces can penetrate FM ordering channels into reconstructed oxyhydroxide layers, thereby activating oxyhydroxide layers as spin-filter to accelerate spin-selective electron transfer. This work provides a new guideline to develop highly efficient spintronic catalysts for water oxidation and other spin-forbidden reactions.展开更多
Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the...Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the most widely approved in situ test method.It can be used to invert soil properties and interpret soil behavior.To analyse the strength properties of surface sediments in the HRD,this paper evaluated the friction angle and its inversion formula through the CPTu penetration test and monotonic simple shear test and other soil unit experiments.The evaluation showed that the empirical formula proposed by Kulhawy and Mayne had better prediction and inversion effect.The HRD silts with clay contents of 9.2%,21.4%and 30.3%were selected as samples for the CPTu variable rate penetration test.The results show as follows.(1)The effects of the clay content on the tip resistance and the pore pressure of silt under different penetration rates were summarized.The tip resistance Q_t is strongly dependent on the clay content of the silt,the B_(q)value of the silt tends to 0 and is not significantly affected by the change of the CPTu penetration rate.(2)Five soil behavior type classification charts and three soil behavior type indexes based on CPTu data were evaluated.The results show that the soil behavior type classification chart based on soil behavior type index ISBT,the Robertson 2010 behavior type classification chart are more suitable for the silty soil in the HRD.展开更多
Visible light(VL)plays an important role in achieving high-precision positioning and low bit error radio(BER)data communication.However,most VL-based systems can not achieve positioning and communication,simultaneousl...Visible light(VL)plays an important role in achieving high-precision positioning and low bit error radio(BER)data communication.However,most VL-based systems can not achieve positioning and communication,simultaneously.There are two problems:1)the hybrid systems are difficult to extract distinguishable positioning beacon features without affecting communication performance,2)in the hybrid systems,the lost data bits in the inter-frame gap(IFG)are hard to recover,which affects positioning and communication performance.Therefore,in this article,we propose a novel VL-based hybrid positioning and communication system,named HY-PC system,to solve the above problems.First,we propose the robust T-W mapping for recognizing specific Light Emitting Diodes(LEDs),which can provide stable LED recognition accuracy without adding extra beacon data and does not decrease the communication rate.Furthermore,we also propose the novel linear block coding and bit interleaving mechanism,which can recover the lost data bits in the IFG and improve data communication performance.Finally,we use commercial off-the-shelf devices to implement our HY-PC system,extensive experimental results show that our HY-PC system can achieve consistent high-precision positioning and low-BER data communication,simultaneously.展开更多
Mobile Edge Computing(MEC)-based computation offloading is a promising application paradigm for serving large numbers of users with various delay and energy requirements.In this paper,we propose a flexible MECbased re...Mobile Edge Computing(MEC)-based computation offloading is a promising application paradigm for serving large numbers of users with various delay and energy requirements.In this paper,we propose a flexible MECbased requirement-adaptive partial offloading model to accommodate each user's specific preference regarding delay and energy consumption.To address the dimensional differences between time and energy,we introduce two normalized parameters and then derive the computational overhead of processing tasks.Different from existing works,this paper considers practical variations in the user request patterns,and exploits a flexible partial offloading mode to minimize computation overheads subject to tolerable delay,task workload and power constraints.Since the resulting problem is non-convex,we decouple it into two convex subproblems and present an iterative algorithm to obtain a feasible offloading solution.Numerical experiments show that our proposed scheme achieves a significant improvement in computation overheads compared with existing schemes.展开更多
In visible light positioning systems,some scholars have proposed target tracking algorithms to balance the relationship among positioning accuracy,real-time performance,and robustness.However,there are still two probl...In visible light positioning systems,some scholars have proposed target tracking algorithms to balance the relationship among positioning accuracy,real-time performance,and robustness.However,there are still two problems:(1)When the captured LED disappears and the uncertain LED reappears,existing tracking algorithms may recognize the landmark in error;(2)The receiver is not always able to achieve positioning under various moving statuses.In this paper,we propose an enhanced visual target tracking algorithm to solve the above problems.First,we design the lightweight recognition/demodulation mechanism,which combines Kalman filtering with simple image preprocessing to quickly track and accurately demodulate the landmark.Then,we use the Gaussian mixture model and the LED color feature to enable the system to achieve positioning,when the receiver is under various moving statuses.Experimental results show that our system can achieve high-precision dynamic positioning and improve the system’s comprehensive performance.展开更多
With the popularity of online learning in educational settings, knowledge tracing(KT) plays an increasingly significant role. The task of KT is to help students learn more effectively by predicting their next mastery ...With the popularity of online learning in educational settings, knowledge tracing(KT) plays an increasingly significant role. The task of KT is to help students learn more effectively by predicting their next mastery of knowledge based on their historical exercise sequences. Nowadays, many related works have emerged in this field, such as Bayesian knowledge tracing and deep knowledge tracing methods. Despite the progress that has been made in KT, existing techniques still have the following limitations: 1) Previous studies address KT by only exploring the observational sparsity data distribution, and the counterfactual data distribution has been largely ignored. 2) Current works designed for KT only consider either the entity relationships between questions and concepts, or the relations between two concepts, and none of them investigates the relations among students, questions, and concepts, simultaneously, leading to inaccurate student modeling. To address the above limitations,we propose a graph counterfactual augmentation method for knowledge tracing. Concretely, to consider the multiple relationships among different entities, we first uniform students, questions, and concepts in graphs, and then leverage a heterogeneous graph convolutional network to conduct representation learning.To model the counterfactual world, we conduct counterfactual transformations on students’ learning graphs by changing the corresponding treatments and then exploit the counterfactual outcomes in a contrastive learning framework. We conduct extensive experiments on three real-world datasets, and the experimental results demonstrate the superiority of our proposed Graph CA method compared with several state-of-the-art baselines.展开更多
Taking an industrial sludge and its preparation of sludge wrap shell aggregates(WSAs)instead of sand to prepare baking-free brick as the research object,the development law of mechanical properties and the influence m...Taking an industrial sludge and its preparation of sludge wrap shell aggregates(WSAs)instead of sand to prepare baking-free brick as the research object,the development law of mechanical properties and the influence mechanism of macro and micro characteristic parameters of the bricks under different sludge and WSAs replacement rates were studied through the macroscopic mechanical properties test,with the help of nuclear magnetic resonance(NMR),transmission electron microscopy-energy spectrum and other testing technology and pores and cracks analysis system(PCAS)software.The results showed that the compressive strength of each sample decreased with the increase of sludge content.When the sludge content was less than 30%,it was mainly affected by the water-binder ratio.When the sludge content was more than 30%,it was mainly affected by the sludge content.At the age of 7 days,with the increase in replacement rate of WSAs,the compressive strength of the S10 and S30 groups was higher than that of the control group.The compressive strength of the S50 experimental group was 30.38 MPa,and the loss of compressive strength was slight compared with the control group.The water absorption rate of the 28 days S100 experimental group increased by 10.71%compared with the control group.When the content of WSAs was less than 50%,the holes above 0.1μm in the brick can be reduced and transformed into smaller holes,with a decreasing trend of the plane porosity of the brick.The microscopic results of the baking-free brick showed that the three-phase system of WSAs-interface transition area-mortar was poorly bonded and delaminated compared with the gravel aggregate-interface transition area-mortar system,and damage was more likely to occur in the WSAs and interface transition area.The above results show that it is feasible to use sludge and WSAs instead of sand for the preparation of baking-free bricks.This technology not only solves the problem of sludge disposal,but also protects the over-exploitation of mineral resources,and the technology has a broad application prospect and market value.展开更多
Hepatic arterioportal fistulas(APFs)are common in hepatocellular carcinoma(HCC).Moreover,correlated with poor prognosis,APFs often complicate antitumor treatments,including transarterial chemoembolization(TACE).AIM To...Hepatic arterioportal fistulas(APFs)are common in hepatocellular carcinoma(HCC).Moreover,correlated with poor prognosis,APFs often complicate antitumor treatments,including transarterial chemoembolization(TACE).AIM To compare the efficacy of ethanol-soaked gelatin sponges(ESG)and microspheres in the management of APFs and their impact on the prognosis of HCC.METHODS Data from patients diagnosed with HCC or hepatic APFs between June 2016 and December 2019 were retrospectively analyzed.Furthermore,APFs were embolized with ESG(group E)or microspheres(group M)during TACE.The primary outcomes were disease control rate(DCR)and objective response rate(ORR).The secondary outcomes included immediate and first follow-up APF improvement,overall survival(OS),and progression-free survival(PFS).RESULTS Altogether,91 participants were enrolled in the study,comprising 46 in group E and 45 in group M.The DCR was 93.5%and 91.1%in groups E and M,respectively(P=0.714).The ORRs were 91.3%and 66.7%in groups E and M,respectively(P=0.004).The APFs improved immediately after the procedure in 43(93.5%)patients in group E and 40(88.9%)patients in group M(P=0.485).After 2 mo,APF improvement was achieved in 37(80.4%)and 33(73.3%)participants in groups E and M,respectively(P=0.421).The OS was 26.2±1.4 and 20.6±1.1 mo in groups E and M,respectively(P=0.004),whereas the PFS was 16.6±1.0 and 13.8±0.7 mo in groups E and M,respectively(P=0.012).CONCLUSION Compared with microspheres,ESG embolization demonstrated a higher ORR and longer OS and PFS in patients of HCC with hepatic APFs.展开更多
This study analyzed the potential impact of the increased oil volatility on the industries and the global economy. Specifically, it separated the oil price fluctuations into positive and negative components, and model...This study analyzed the potential impact of the increased oil volatility on the industries and the global economy. Specifically, it separated the oil price fluctuations into positive and negative components, and modeled the return of industry portfolios with them. Next, the sensitivity of the airline industry to oil price was investigated to gauge the effectiveness of their hedging strategies, with the hope that the methodology can be extended to other industries. In addition, this paper explored the macroeconomic impact of oil price movements by examining the benchmarks such as GDP and CPI.展开更多
Teaching security management is important for institutions to effectively manage teaching resources.This article takes Xi’an Mingde Institute of Technology(referred to as Mingde Institute)as the research subject and ...Teaching security management is important for institutions to effectively manage teaching resources.This article takes Xi’an Mingde Institute of Technology(referred to as Mingde Institute)as the research subject and uses the literature review and field investigation to put forward relevant suggestions for the teaching facilities of Mingde Institute,in order to improve the teaching facilities of Mingde Institute.展开更多
文摘Background: Hypertension is a universal risk factor for cardiovascular diseases and is thus the leading cause of death worldwide. The identification of novel prognostic and pathogenesis biomarkers plays a key role in disease management. Methods: The GSE145854 and GSE164494 datasets were downloaded from the Gene Expression Omnibus (GEO) database and used for screening and validating hypertension signature genes, respectively. Gene Ontology (GO) enrichment analysis was performed on the differentially expressed genes (DEGs) related to calcium ion metabolism in patients with hypertension. The core genes related to immune infiltration were analyzed and screened, and the activity of the signature genes and related pathways was quantified using gene set enrichment analysis (GSEA). The infiltration of immune cells in the blood samples was analyzed, and the DEGs that were abnormally expressed in the clinical blood samples of patients with hypertension were verified via RT-qPCR. Results: A total of 176 DEGs were screened. GO showed that DEGs was involved in the regulation of calcium ion metabolism in biological processes (BP), actin mediated cell contraction, negative regulation of cell movement, and calcium ion transmembrane transport, and in the regulation of protease activity in molecular functions (MF). KEGG analysis revealed that the DEGs were involved mainly in the cGMP-PKG signaling pathway, ubiquitin-protein transferase, tight junction-associated proteins, and the regulation of myocardial cells. MF analysis revealed the immune infiltration function of the cells. RT-qPCR revealed that the expression of Cacna1d, Serpine1, Slc8a3, and Trpc4 was up regulated in hypertension, the expression of Myoz2 and Slc25a23 was down regulated. Conclusion: Cacna1d, Serpine1, Slc8a3, Trpc4, Myoz2 and Slc25a23 may be involved in the regulation of calcium metabolism pathways and play key roles in hypertension. These differentially expressed calcium metabolism-related genes may serve as prognostic markers of hypertension.
文摘Background: Hypertension, also known as increased blood pressure, is a phenomenon in which blood flows in blood vessels and causes persistently higher-than-normal pressure on the vessel wall. The identification of novel prognostic and pathogenesis biomarkers plays a key role in the management of hypertension. Methods: The GSE7483 and GSE75815 datasets from the gene expression omnibus (GEO) database were used to identify the genes associated with hypertension that were differentially expressed genes (DEGs). The functional role of the DEGs was elucidated by gene body (GO) enrichment analysis. In addition, we performed an immune infiltration assay and GSEA on the DEGs of hypertensive patients and verified the expression of novel DEGs in the blood of hypertensive patients by RT-qPCR. Results: A total of 267 DEGs were identified from the GEO database. GO analysis revealed that these genes were associated mainly with biological processes such as fibroblast proliferation, cell structural organization, extracellular matrix organization, vasculature development regulation, and angiogenesis. We identified five possible biomarkers, Ecm1, Sparc, Sphk1, Thbsl, and Mecp2, which correlate with vascular development and angiogenesis characteristic of hypertension by bioinformatics, and explored the clinical expression levels of these genes by RT-qPCR, and found that Sparc, Sphk1, and Thbs1 showed significant up-regulation, in agreement with the results of the bioinformatics analysis. Conclusion: Our study suggested that Sparc, Sphk1 and Thbs1 may be potential novel biomarkers for the diagnosis, treatment and prognosis of hypertension and that they are involved in the regulation of vascular development and angiogenesis in hypertension.
基金supported by the Science and Technology Special Plan Project from China Minmetals Group (No.2020ZXA01)the International Exchange and Growth Program for Young Teachers (No.QNXM20220061)the National Key Research and Development Program of China (No.2022YFC2906100).
文摘Boron is an important industrial raw material often sourced from minerals containing different compounds that cocrystallize,which makes it difficult to separate the mineral phases through conventional beneficiation.This study proposed a new treatment called flash reduction-melting separation(FRMS)for boron-bearing iron concentrates.In this method,the concentrates were first flash-reduced at the temperature under which the particles melt,and the slag and the reduced iron phases disengaged at the particle scale.Good reduc-tion and melting effects were achieved above 1550℃.The B_(2)O_(3) content in the separated slag was over 18wt%,and the B content in the iron was less than 0.03wt%.The proposed FRMS method was tested to investigate the effects of factors such as ore particle size and tem-perature on the reduction and melting steps with and without pre-reducing the raw concentrate.The mineral phase transformation and morphology evolution in the ore particles during FRMS were also comprehensively analyzed.
基金Supported by Xi’an Municipal Health Commission of China,No.2022qn07 and No.2023ms11.
文摘As a highly invasive malignancy,esophageal cancer(EC)is a global health issue,and was the eighth most prevalent cancer and the sixth leading cause of cancerrelated death worldwide in 2020.Due to its highly immunogenic nature,emerging immunotherapy approaches,such as immune checkpoint blockade,have demonstrated promising efficacy in treating EC;however,certain limitations and challenges still exist.In addition,tumors may exhibit primary or acquired resistance to immunotherapy in the tumor immune microenvironment(TIME);thus,understanding the TIME is urgent and crucial,especially given the importance of an immunosuppressive microenvironment in tumor progression.The aim of this review was to better elucidate the mechanisms of the suppressive TIME,including cell infiltration,immune cell subsets,cytokines and signaling pathways in the tumor microenvironment of EC patients,as well as the downregulated expression of major histocompatibility complex molecules in tumor cells,to obtain a better understanding of the differences in EC patient responses to immunotherapeutic strategies and accurately predict the efficacy of immunotherapies.Therefore,personalized treatments could be developed to maximize the advantages of immunotherapy.
基金funded by the National Key R&D Program of China(No.2021YFD1300202)the nutritional value evaluation and parameter establishment of protein feedstuffs for sowsthe Ministry of Agriculture and Rural Affairs of the People’s Republic of China(125D0203-16190295)the Major Scientific and Technological Special Project of Sichuan Province(No.2021ZDZX0009)。
文摘Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant sows.Seven solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were selected.In Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N source.Eight non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in Exp.1.Eight gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation stages.Results When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,Gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(P<0.05),whereas SID for Leu from SBM 5 was higher than in SBM 1 and 4(P<0.05).SID values for Ile,Ala,and Asp from SBM 4 were lower than in SBM 1 and 5(P<0.05).Sows had significantly greater SID values for Lys,Ala,and Asp during mid-gestation when compared with late-gestation stages(P<0.05).Mid-gestating sows had greater SID value for Val and lower SID value for Tyr when compared with non-pregnant and late-gestating sows(P<0.01),whereas non-pregnant sows had significantly greater SID value for Met when compared with gestating sows(P<0.01).Conclusions When fed to mid-gestating sows,the SID values for most AAs varied among SBM samples.The SID values for Lys,Met,Val,Ala,Asp,and Tyr in SBM were affected by sow gestation stages.Our findings provide a cornerstone for accurate SBM use in sow diets.
基金Supported by the Xi'an Municipal Health Commission of China,No.2022qn07the Xi'an Municipal Health Commission of China,No.2020ms14the Shaanxi Natural Science Foundation of China,No.2019JQ-978.
文摘Gastric cancer(GC)is defined as the primary epithelial malignancy derived from the stomach,and it is a complicated and heterogeneous disease with multiple risk factors.Despite its overall declining trend of incidence and mortality in various countries over the past few decades,GC remains the fifth most common malignancy and the fourth leading cause of cancer-related death globally.Although the global burden of GC has shown a significant downward trend,it remains severe in certain areas,such as Asia.GC ranks third in incidence and mortality among all cancer types in China,and it accounts for nearly 44.0%and 48.6%of new GC cases and GC-related deaths in the world,respectively.The regional differences in GC incidence and mortality are obvious,and annual new cases and deaths are increasing rapidly in some developing regions.Therefore,early preventive and screening strategies for GC are urgently needed.The clinical efficacies of conventional treatments for GC are limited,and the developing understanding of GC pathogenesis has increased the demand for new therapeutic regimens,including immune checkpoint inhibitors,cell immunotherapy and cancer vaccines.The present review describes the epidemiology of GC worldwide,especially in China,summarizes its risk and prognostic factors,and focuses on novel immunotherapies to develop therapeutic strategies for the management of GC patients.
基金supported by the National Key R&D Program of China (2020YFA0710000)the National Natural Science Foundation of China (22278307, 22008170, 21978200, 22161142002, and 22121004)+2 种基金the Applied Basic Research Program of Qinghai Province (2023-ZJ-701)the Haihe Laboratory of Sustainable Chemical Transformationsthe Tianjin Research Innovation Project for Postgraduate Students (2022BKYZ035)。
文摘Sluggish reaction kinetics of oxygen evolution reaction(OER), resulting from multistep proton-coupled electron transfer and spin constriction, limits overall efficiency for most reported catalysts. Herein, using modeled ZnFe_(2-x)Ni_xO_(4)(0 ≤ x ≤ 0.4) spinel oxides, we aim to develop better OER electrocatalyst through combining the construction of ferromagnetic(FM) ordering channels and generation of highly active reconstructed species. The number of symmetry-breaking Fe–O–Ni structure links to the formation of FM ordering electron transfer channels. Meanwhile, as the number of Ni^(3+)increases, more ligand holes are formed, beneficial for redirecting surface reconstruction. The electro-activated ZnFe_(1.6)Ni_(0.4)O_(4) shows the highest specific activity, which is 13 and 2.5 times higher than that of ZnFe_(2)O_(4) and unactivated ZnFe_(1.6)Ni_(0.4)O_(4), and even superior to the benchmark IrO_(2) under the overpotential of 350 mV. Applying external magnetic field can make electron spin more aligned, and the activity can be further improved to 39 times of ZnFe_(2)O_(4). We propose that intriguing FM exchange-field interaction at FM/paramagnetic interfaces can penetrate FM ordering channels into reconstructed oxyhydroxide layers, thereby activating oxyhydroxide layers as spin-filter to accelerate spin-selective electron transfer. This work provides a new guideline to develop highly efficient spintronic catalysts for water oxidation and other spin-forbidden reactions.
基金The National Natural Science Foundation of China under contract No.U2006213。
文摘Fine-grained silt is widely distributed in the Huanghe River Delta(HRD)in China,and the sedimentary structure is complex,meaning that the clay content in the silt is variable.The piezocone penetration test(CPTu)is the most widely approved in situ test method.It can be used to invert soil properties and interpret soil behavior.To analyse the strength properties of surface sediments in the HRD,this paper evaluated the friction angle and its inversion formula through the CPTu penetration test and monotonic simple shear test and other soil unit experiments.The evaluation showed that the empirical formula proposed by Kulhawy and Mayne had better prediction and inversion effect.The HRD silts with clay contents of 9.2%,21.4%and 30.3%were selected as samples for the CPTu variable rate penetration test.The results show as follows.(1)The effects of the clay content on the tip resistance and the pore pressure of silt under different penetration rates were summarized.The tip resistance Q_t is strongly dependent on the clay content of the silt,the B_(q)value of the silt tends to 0 and is not significantly affected by the change of the CPTu penetration rate.(2)Five soil behavior type classification charts and three soil behavior type indexes based on CPTu data were evaluated.The results show that the soil behavior type classification chart based on soil behavior type index ISBT,the Robertson 2010 behavior type classification chart are more suitable for the silty soil in the HRD.
基金supported by the Guangdong Basic and Applied Basic Research Foundation No.2021A1515110958National Natural Science Foundation of China No.62202215+2 种基金SYLU introduced high-level talents scientific research support planChongqing University Innovation Research Group(CXQT21019)Chongqing Talents Project(CQYC201903048)。
文摘Visible light(VL)plays an important role in achieving high-precision positioning and low bit error radio(BER)data communication.However,most VL-based systems can not achieve positioning and communication,simultaneously.There are two problems:1)the hybrid systems are difficult to extract distinguishable positioning beacon features without affecting communication performance,2)in the hybrid systems,the lost data bits in the inter-frame gap(IFG)are hard to recover,which affects positioning and communication performance.Therefore,in this article,we propose a novel VL-based hybrid positioning and communication system,named HY-PC system,to solve the above problems.First,we propose the robust T-W mapping for recognizing specific Light Emitting Diodes(LEDs),which can provide stable LED recognition accuracy without adding extra beacon data and does not decrease the communication rate.Furthermore,we also propose the novel linear block coding and bit interleaving mechanism,which can recover the lost data bits in the IFG and improve data communication performance.Finally,we use commercial off-the-shelf devices to implement our HY-PC system,extensive experimental results show that our HY-PC system can achieve consistent high-precision positioning and low-BER data communication,simultaneously.
基金This work was supported in part by the National Natural Science Foundation of China under Grant 62171113 and 61941113in part by the Fundamental Research Funds for the Central Universities under Grant N2116003 and N2116011.
文摘Mobile Edge Computing(MEC)-based computation offloading is a promising application paradigm for serving large numbers of users with various delay and energy requirements.In this paper,we propose a flexible MECbased requirement-adaptive partial offloading model to accommodate each user's specific preference regarding delay and energy consumption.To address the dimensional differences between time and energy,we introduce two normalized parameters and then derive the computational overhead of processing tasks.Different from existing works,this paper considers practical variations in the user request patterns,and exploits a flexible partial offloading mode to minimize computation overheads subject to tolerable delay,task workload and power constraints.Since the resulting problem is non-convex,we decouple it into two convex subproblems and present an iterative algorithm to obtain a feasible offloading solution.Numerical experiments show that our proposed scheme achieves a significant improvement in computation overheads compared with existing schemes.
基金supported by the Guangdong Basic and Applied Basic Research Foundation No.2021A1515110958National Natural Science Foundation of China No.62202215+1 种基金SYLU introduced high-level talents scientific research support plan,Chongqing University Innovation Research Group(CXQT21019)Chongqing Talents Project(CQYC201903048)。
文摘In visible light positioning systems,some scholars have proposed target tracking algorithms to balance the relationship among positioning accuracy,real-time performance,and robustness.However,there are still two problems:(1)When the captured LED disappears and the uncertain LED reappears,existing tracking algorithms may recognize the landmark in error;(2)The receiver is not always able to achieve positioning under various moving statuses.In this paper,we propose an enhanced visual target tracking algorithm to solve the above problems.First,we design the lightweight recognition/demodulation mechanism,which combines Kalman filtering with simple image preprocessing to quickly track and accurately demodulate the landmark.Then,we use the Gaussian mixture model and the LED color feature to enable the system to achieve positioning,when the receiver is under various moving statuses.Experimental results show that our system can achieve high-precision dynamic positioning and improve the system’s comprehensive performance.
基金supported by the Natural Science Foundation of China (62372277)the Natural Science Foundation of Shandong Province (ZR2022MF257, ZR2022MF295)Humanities and Social Sciences Fund of the Ministry of Education (21YJC630157)。
文摘With the popularity of online learning in educational settings, knowledge tracing(KT) plays an increasingly significant role. The task of KT is to help students learn more effectively by predicting their next mastery of knowledge based on their historical exercise sequences. Nowadays, many related works have emerged in this field, such as Bayesian knowledge tracing and deep knowledge tracing methods. Despite the progress that has been made in KT, existing techniques still have the following limitations: 1) Previous studies address KT by only exploring the observational sparsity data distribution, and the counterfactual data distribution has been largely ignored. 2) Current works designed for KT only consider either the entity relationships between questions and concepts, or the relations between two concepts, and none of them investigates the relations among students, questions, and concepts, simultaneously, leading to inaccurate student modeling. To address the above limitations,we propose a graph counterfactual augmentation method for knowledge tracing. Concretely, to consider the multiple relationships among different entities, we first uniform students, questions, and concepts in graphs, and then leverage a heterogeneous graph convolutional network to conduct representation learning.To model the counterfactual world, we conduct counterfactual transformations on students’ learning graphs by changing the corresponding treatments and then exploit the counterfactual outcomes in a contrastive learning framework. We conduct extensive experiments on three real-world datasets, and the experimental results demonstrate the superiority of our proposed Graph CA method compared with several state-of-the-art baselines.
基金the Natural Science Foundation of Henan Province(202300410270)Graduate Education Innovation Program fund of North China University of Water Resources and Electric Power(YK-2021-49).
文摘Taking an industrial sludge and its preparation of sludge wrap shell aggregates(WSAs)instead of sand to prepare baking-free brick as the research object,the development law of mechanical properties and the influence mechanism of macro and micro characteristic parameters of the bricks under different sludge and WSAs replacement rates were studied through the macroscopic mechanical properties test,with the help of nuclear magnetic resonance(NMR),transmission electron microscopy-energy spectrum and other testing technology and pores and cracks analysis system(PCAS)software.The results showed that the compressive strength of each sample decreased with the increase of sludge content.When the sludge content was less than 30%,it was mainly affected by the water-binder ratio.When the sludge content was more than 30%,it was mainly affected by the sludge content.At the age of 7 days,with the increase in replacement rate of WSAs,the compressive strength of the S10 and S30 groups was higher than that of the control group.The compressive strength of the S50 experimental group was 30.38 MPa,and the loss of compressive strength was slight compared with the control group.The water absorption rate of the 28 days S100 experimental group increased by 10.71%compared with the control group.When the content of WSAs was less than 50%,the holes above 0.1μm in the brick can be reduced and transformed into smaller holes,with a decreasing trend of the plane porosity of the brick.The microscopic results of the baking-free brick showed that the three-phase system of WSAs-interface transition area-mortar was poorly bonded and delaminated compared with the gravel aggregate-interface transition area-mortar system,and damage was more likely to occur in the WSAs and interface transition area.The above results show that it is feasible to use sludge and WSAs instead of sand for the preparation of baking-free bricks.This technology not only solves the problem of sludge disposal,but also protects the over-exploitation of mineral resources,and the technology has a broad application prospect and market value.
文摘Hepatic arterioportal fistulas(APFs)are common in hepatocellular carcinoma(HCC).Moreover,correlated with poor prognosis,APFs often complicate antitumor treatments,including transarterial chemoembolization(TACE).AIM To compare the efficacy of ethanol-soaked gelatin sponges(ESG)and microspheres in the management of APFs and their impact on the prognosis of HCC.METHODS Data from patients diagnosed with HCC or hepatic APFs between June 2016 and December 2019 were retrospectively analyzed.Furthermore,APFs were embolized with ESG(group E)or microspheres(group M)during TACE.The primary outcomes were disease control rate(DCR)and objective response rate(ORR).The secondary outcomes included immediate and first follow-up APF improvement,overall survival(OS),and progression-free survival(PFS).RESULTS Altogether,91 participants were enrolled in the study,comprising 46 in group E and 45 in group M.The DCR was 93.5%and 91.1%in groups E and M,respectively(P=0.714).The ORRs were 91.3%and 66.7%in groups E and M,respectively(P=0.004).The APFs improved immediately after the procedure in 43(93.5%)patients in group E and 40(88.9%)patients in group M(P=0.485).After 2 mo,APF improvement was achieved in 37(80.4%)and 33(73.3%)participants in groups E and M,respectively(P=0.421).The OS was 26.2±1.4 and 20.6±1.1 mo in groups E and M,respectively(P=0.004),whereas the PFS was 16.6±1.0 and 13.8±0.7 mo in groups E and M,respectively(P=0.012).CONCLUSION Compared with microspheres,ESG embolization demonstrated a higher ORR and longer OS and PFS in patients of HCC with hepatic APFs.
文摘This study analyzed the potential impact of the increased oil volatility on the industries and the global economy. Specifically, it separated the oil price fluctuations into positive and negative components, and modeled the return of industry portfolios with them. Next, the sensitivity of the airline industry to oil price was investigated to gauge the effectiveness of their hedging strategies, with the hope that the methodology can be extended to other industries. In addition, this paper explored the macroeconomic impact of oil price movements by examining the benchmarks such as GDP and CPI.
基金This work was funded by Research on Teaching Guarantee of Mingde College Based on Undergraduate Qualified Teaching Evaluation(Fund number:JG2023YB05[Z])。
文摘Teaching security management is important for institutions to effectively manage teaching resources.This article takes Xi’an Mingde Institute of Technology(referred to as Mingde Institute)as the research subject and uses the literature review and field investigation to put forward relevant suggestions for the teaching facilities of Mingde Institute,in order to improve the teaching facilities of Mingde Institute.
